A5047494050- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- 3D Printing in Biomedical Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- Pancreatic function and diabetes
- Sulfur Compounds in Biology
- Cell Image Analysis Techniques
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Inflammatory mediators and NSAID effects
- Redox biology and oxidative stress
- Liver physiology and pathology
- Computational Drug Discovery Methods
- Glutathione Transferases and Polymorphisms
- Ferroptosis and cancer prognosis
- Genomics, phytochemicals, and oxidative stress
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer Cells and Metastasis
Izmir University
2018-2025
Dokuz Eylül University
2018-2023
Lusaka Apex Medical University
2020-2021
Institute for Biomedicine
2017
<b><i>Objective:</i></b> Levels of serum albumin have recently emerged, together with C-reactive protein, as an important prognostic indicator for hepatocellular carcinoma (HCC). It has been reported that larger HCCs are associated lower levels. However, the albumin-mediated growth decrease yet to be determined. <b><i>Methods:</i></b> We examined a large HCC cohort and then by direct exposure cells in vitro, relationship levels growth....
Abstract Background Epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial (MET) are both reversible processes, regulation of phenotypical is very important for progression several cancers including hepatocellular carcinoma (HCC). Recently, it defined that cancer cells can attain a hybrid epithelial/mesenchymal (hybrid E/M) phenotype. Cells with E/M phenotype comprise mixed epithelial mesenchymal properties, they be more resistant to therapeutics also capable initiating...
Aim: Hepatocellular carcinoma (HCC) in patients with Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) is expected to be a significant public health issue the near future. Therefore, understanding tumor microenvironment interactions MASLD-induced HCC crucial, and development of relevant preclinical models needed. Hence, we aimed determine effects MASLD-mimicking (ME) on aggressiveness cells identify target genes that drive by developing 3D-in vitro co-culture...
Hepatocellular carcinoma (HCC) is strongly associated with metabolic dysregulations/deregulations and hyperglycemia a common disturbance in diseases. Hyperglycemia defined to promote epithelial mesenchymal transition (EMT) of cancer cells various cancers but its molecular contribution HCC progression aggressiveness relatively unclear. In this study, we analyzed the mechanisms behind hyperglycemia-induced EMT cell lines. Here, report that high glucose promotes through activating c-Met...
// Aysim Gunes 1 , Ezgi Bagirsakci Evin Iscan Gulcin Cakan-Akdogan Umut Aykutlu 2 Serif Senturk Ozhan Esra Erdal Deniz Nart Funda Yilmaz Barbet and Nese Atabey Izmir Biomedicine Genome Center, Izmir, 35340 Balcova, Turkey Ege University, Faculty of Medicine, Department Pathology, 35040 Bornova, Correspondence to: Atabey, email: nese.atabey@ibg.edu.tr Keywords: HCC; oxidative stress; TXNIP; EMT; metastasis Received: January 08, 2018 Accepted: November 16, Published: December 07, ABSTRACT...
Abstract Background: Epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial (MET) are both reversible processes, regulation of phenotypical is very important for progression several cancers including hepatocellular carcinoma (HCC). Recently, it defined that cancer cells can attain a hybrid epithelial/mesenchymal (hybrid E/M) phenotype. Cells with E/M phenotype comprise mixed epithelial mesenchymal properties, they be more resistant to therapeutics also capable initiating...
Introduction Lab-on-a-chip (LOC) systems can present cells multiple cues that are subjected to, including gradients of cytokines and secreted proteins from neighbouring cells, biochemical mechanical interactions with the extracellular matrix, direct cell-to-cell contacts in a controllable reproducible fashion. Simulating microenvironment LOC devices is crucial to understand metastasis preference cancer especially for planning personalised therapies hepatocellular carcinoma (HCC). Material...
Abstract Background: Epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial (MET) are both reversible processes, regulation of phenotypical is very important for progression several cancers including hepatocellular carcinoma (HCC). Recently, it defined that cancer cells can attain a hybrid epithelial/mesenchymal (hybrid E/M) phenotype. Cells with E/M phenotype comprise mixed epithelial mesenchymal properties, they be more resistant to therapeutics also capable initiating...
Abstract Purpose Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related death worldwide with. lack effective systemic chemotherapy. In this study, we aimed to evaluate value ATPase family AAA domain-containing protein 2 (ATAD2) as a biomarker and potential therapeutic target for HCC. Methods The expression ATAD2 was tested in different HCC patient cohorts by immunohistochemistry comparative transcriptional analysis. co-expression proliferation markers compared during...