A5054354159- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Hepatitis B Virus Studies
- Listeria monocytogenes in Food Safety
- Liver Disease Diagnosis and Treatment
- DNA Repair Mechanisms
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Adenosine and Purinergic Signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic function and diabetes
Izmir University
2020-2022
Dokuz Eylül University
2016-2021
Lusaka Apex Medical University
2021
Aim To investigate the expression of DNA repair genes and impact breast cancer 1, early onset (BRCA1) protein on chemoresistance hepatocellular carcinoma (HCC). Methods Microarray gene datasets were analyzed using set enrichment analysis method. BRCA1 was tested by Western blotting. Response HCC cells to interstrand cross‐links investigated cell viability assay following exposure mitomycin C, cisplatin, melphalan. Effects ectopic studied in HepG2 with ‐expression plasmids. downregulation...
Selective autophagy of the endoplasmic reticulum (ER), namely ER-phagy, is mediated by ER-localized receptors, which are recognized and sequestered GABARAP/LC3B-decorated phagophores transferred to lysosomes for degradation. Being one such receptor, FAM134B plays critical roles in cellular processes as protein quality control neuronal survival. has also been associated with different cancers, although its exact role remains elusive. We report here that gene encodes not but at least two...
Hepatocyte dedifferentiation is a major source of hepatocellular carcinoma (HCC), but its mechanisms are unknown. We explored the p73 expression in HCC tumors and studied effects transcriptionally active p73β (TAp73β) cells. Expression profiles patient clinical data were collected from Genomic Data Commons (GDC) portal TSVdb database, respectively. Global gene determined by pan-genomic 54K microarrays. The Gene Set Enrichment Analysis method was used to identify TAp73β-regulated sets. TAp73...
Abstract Purpose Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related death worldwide with. lack effective systemic chemotherapy. In this study, we aimed to evaluate value ATPase family AAA domain-containing protein 2 (ATAD2) as a biomarker and potential therapeutic target for HCC. Methods The expression ATAD2 was tested in different HCC patient cohorts by immunohistochemistry comparative transcriptional analysis. co-expression proliferation markers compared during...