A5085935720- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Biological Activity of Diterpenoids and Biflavonoids
- Cancer-related gene regulation
- Telomeres, Telomerase, and Senescence
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Plant biochemistry and biosynthesis
- Computational Drug Discovery Methods
- Inflammasome and immune disorders
- Ferroptosis and cancer prognosis
- Fungal Plant Pathogen Control
- Inflammatory Bowel Disease
- Genomic variations and chromosomal abnormalities
- Gene expression and cancer classification
- Gout, Hyperuricemia, Uric Acid
- TGF-β signaling in diseases
- Autism Spectrum Disorder Research
- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cell Adhesion Molecules Research
- Chromosomal and Genetic Variations
- Bioinformatics and Genomic Networks
- Mitochondrial Function and Pathology
- BRCA gene mutations in cancer
Karadeniz Technical University
2018-2023
Erzincan University
2016-2017
Inserm
2013-2016
Université Joseph Fourier
2013-2016
Université Grenoble Alpes
2013-2016
Institut pour l'avancée des biosciences
2013
Bilkent University
2013
Senescence is a permanent proliferation arrest in response to cell stress such as DNA damage. It contributes strongly tissue aging and serves major barrier against tumor development. Most cells are believed bypass the senescence (become "immortal") by inactivating growth control genes TP53 CDKN2A. They also reactivate telomerase reverse transcriptase. Senescence-to-immortality transition accompanied phenotypic biochemical changes mediated genome-wide transcriptional modifications. This...
Aim To investigate the expression of DNA repair genes and impact breast cancer 1, early onset (BRCA1) protein on chemoresistance hepatocellular carcinoma (HCC). Methods Microarray gene datasets were analyzed using set enrichment analysis method. BRCA1 was tested by Western blotting. Response HCC cells to interstrand cross‐links investigated cell viability assay following exposure mitomycin C, cisplatin, melphalan. Effects ectopic studied in HepG2 with ‐expression plasmids. downregulation...
Hepatocyte dedifferentiation is a major source of hepatocellular carcinoma (HCC), but its mechanisms are unknown. We explored the p73 expression in HCC tumors and studied effects transcriptionally active p73β (TAp73β) cells. Expression profiles patient clinical data were collected from Genomic Data Commons (GDC) portal TSVdb database, respectively. Global gene determined by pan-genomic 54K microarrays. The Gene Set Enrichment Analysis method was used to identify TAp73β-regulated sets. TAp73...
Receptor-interacting serine/threonine kinase 4 (RIPK4) and transforming growth factor-β 1 (TGF-β1) play critical roles in the development maintenance of epidermis. A negative correlation between expression patterns RIPK4 TGF-β signaling during epidermal homeostasis-related events suppression by TGF-β1 keratinocyte cell lines suggest presence a regulatory loop two factors. So far, has been shown to regulate nuclear factor-κB (NF-κB), protein C (PKC), wingless-type MMTV integration site family...
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and third‑leading cause malignancy‑associated mortality worldwide. HCC cells are highly resistant to chemotherapeutic agents. Therefore, there currently only two US Food Drug Administration‑approved drugs available for treatment HCC. The objective present study was analyze results previously published high‑throughput drug screening, in vitro genomic transcriptomic data from cell lines, integrate obtained define underlying...
The purpose of present work is to synthesize novel (+)-Dehydroabietylamine derivatives (DAAD) using N-acetyl-α-amino acid conjugates and determine its cytotoxic effects on hepatocellular carcinoma cells.An analytical study was conducted explore activity DAAD cell lines. cytotoxicity effect recorded sulforhodamine B technique. Cell cycle analysis performed Propidium Iodide (PI) staining. Based morphology, anti growth microarray findings DAAD2 treatment, Comet assay, Annexin V/PI staining,...
Genetic etiologies of autism spectrum disorders (ASD) are complex, and the genetic factors identified so far very diverse. In complex diseases such as ASD, de novo or inherited chromosomal abnormalities valuable findings for researchers with respect to identifying underlying risk factors. With gene mapping studies on these abnormalities, dozens genes have been associated ASD other neurodevelopmental diseases. present study, we aimed idenitfy causative in patients who an apparently balanced...
Hereditary angioedema is a rare autosomal dominantly inherited immunodeficiency disorder characterized by potentially life-threatening attacks.We aimed to investigate the clinical and genetic features of family with attacks.The medical history, C1-INH gene mutation Turkish were investigated outcomes long-term treatments described.Five members had experienced recurrent swellings on face extremities triggered trauma. They all misdiagnosed as familial Mediterranean fever (FMF) depending...
Abstract Bartsocas‐Papas syndrome (BPS) is a rare autosomal recessive disorder characterized by popliteal pterygia, syndactyly, ankyloblepharon, filiform bands between the jaws, cleft lip and palate, genital malformations. Most of BPS cases reported to date are fatal either in prenatal or neonatal period. Causative genetic defects were mapped on RIPK4 gene encoding receptor‐interacting serine/threonine kinase 4, which critical for epidermal differentiation development. variants associated...
Objectives: Ulcerative colitis (UC) is an inflammatory disease restricted to the colon's mucosal layer. UC a complex with largely unknown etiology. Mendelian Randomization (MR) method that uses variations in genes have causal effect of modifiable exposure disease, genetic epidemiological studies. Trefoil factor 3 (TFF3) secreted protein expressed mainly colonic mucosa binds mucin 2 protein, forming protective barrier for colon from bacteria and other insults. This study aimed identify if...