A5082504401- Blood Coagulation and Thrombosis Mechanisms
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Venous Thromboembolism Diagnosis and Management
- Hemophilia Treatment and Research
- Inflammasome and immune disorders
- Trace Elements in Health
- Folate and B Vitamins Research
- Protease and Inhibitor Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- Blood properties and coagulation
- Forensic and Genetic Research
- Hemostasis and retained surgical items
- Blood groups and transfusion
- Cardiovascular Issues in Pregnancy
- Genetic diversity and population structure
- Atrial Fibrillation Management and Outcomes
- Pregnancy and preeclampsia studies
- interferon and immune responses
- Acute Lymphoblastic Leukemia research
- Pharmacological Effects and Toxicity Studies
- Renin-Angiotensin System Studies
- Erythrocyte Function and Pathophysiology
- Ocular Diseases and Behçet’s Syndrome
TOBB University of Economics and Technology
2014-2023
Ankara University
2009-2018
Niğde Ömer Halisdemir Üniversitesi
2018
Akdeniz University
1993-2015
Ufuk University
2015
Cukurova University
2015
Necmettin Erbakan University
2015
Istanbul University
2015
Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi
2011
Laboratory of Molecular Genetics
2009
Differences in clinical manifestations of familial Mediterranean fever (FMF) between different ethnic groups have been documented. The FMF gene was recently cloned and four missense mutations (Met694Val, Met680Ile, Val726Ala, Met694Ile) that account for a large percentage the patients were identified. results initial mutation studies led to hypothesis phenotypic variation disease may be attributable existence some these mutations. purpose this study evaluate whether is associated with...
Senescence is a permanent proliferation arrest in response to cell stress such as DNA damage. It contributes strongly tissue aging and serves major barrier against tumor development. Most cells are believed bypass the senescence (become "immortal") by inactivating growth control genes TP53 CDKN2A. They also reactivate telomerase reverse transcriptase. Senescence-to-immortality transition accompanied phenotypic biochemical changes mediated genome-wide transcriptional modifications. This...
Familial Mediterranean fever (FMF) is a recessive inherited disorder affecting Sephardic Jews, Arabs, Armenians and Turks. The gene responsible for FMF was recently cloned several disease-associated mutations have been described. We evaluated seven MEFV in 460 chromosomes of 230 unrelated patients with living Turkey, using PCR methods. M694V allele accounted 43.5% the alleles studied 19.1% were homozygous. M680I, V726A M694I 12.0%, 11.1% 2.8% respectively. R761H, K695R E148Q rarely...
The global pattern of variation at the homologous microsatellite loci DYS413 (Yq11) and DXS8174 DXS8175 (Xp22) was analyzed by examination 30 world populations from four continents, accounting for more than 1,100 chromosomes per locus. data showed discordant patterns among- within-population gene diversity Y-linked X-linked microsatellites. For polymorphism, all groups displayed high FST values (the correlation between random haplotypes within subpopulations, relative to total population) a...
Haplogroup E, defined by mutation M40, is the most common human Y chromosome clade within Africa. To increase level of resolution haplogroup we disclosed phylogenetic relationships among 729 mutations found in 33 DE Y-chromosomes sequenced at high coverage previous studies. Additionally, dissected E-M35 subclade genotyping 62 informative markers 5,222 samples from 118 worldwide populations. The phylogeny E showed novel features compared with topology, including a new basal dichotomy. Within...
Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by recurrent self‐limited attacks of fever accompanied peritonitis, pleuritis and arthritis. Approximately 5% individuals with FMF have been reported to Henoch‐Schonlein purpura (HSP) about 1% polyarteritis nodosa (PAN). Protracted febrile myalgia another vasculitis‐associated clinical entity among patients FMF. Recently, the gene responsible for FMF, MEFV, has cloned four missense mutations (M680I, M694V,...
This study presents the update results of an ongoing project on delineation spectrum mutations at Wilson disease (WD) gene in WD patients Mediterranean origin. In studying 59 patients, whom were 26 Continental Italians, 22 Sardinians, 9 Turkish, and 2 Albanians, we have found 31 novel three known mutations. Of mutations, 3 are deletions, two nonsense, splice or consensus site, 24 missense. The large majority missense lie evolutionary conserved regions documented functional importance. Most...
Linear growth was evaluated in 32 patients with beta-thalassemia major. At the beginning of study 40.6% were below 10th percentile biochemical evidence zinc deficiency. Effects supplementation on velocity (height) assessed a controlled manner. Twenty-one children received oral sulphate for period 1 to 7 years (15 early- and 6 late-supplemented cases), while remaining 11 thalassemics maintained only conventional transfusion therapy. The mean height early-zinc supplemented significantly...
Several genetic polymorphisms have been identified in patients with sepsis and severe sepsis, such as the tumor necrosis factor-α (TNF-α) TNF-β genes, interleukin-1 (IL-1) family, IL-6, IL-10, CD-14, Toll-like receptors, plasminogen activator inhibitor type 1, factor V 1691G-A mutations. In this study, relationship between TNF-α 308G/A, IL-6-174 G/C, PAI-1, FVL, EPCR, Cathepsin G (Ars 125 Ser) development outcome of pediatric was studied. 308 G/A, PAI-1 4G/4G, EPCR mutations influence risk...
Objective: Ankaferd® Blood Stopper (ABS) comprises a standardized mixture of the plants Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica.The basic mechanism action for ABS is formation an encapsulated protein network that provides focal points vital erythrocyte aggregation.ABSinduced with blood cells, particularly erythrocytes, covers primary secondary hemostatic system without disturbing individual coagulation factors. Materials Methods:To...
Background : Alterations in platelet function and antioxidant status children with iron‐deficiency anemia (IDA) have been reported previously. The present study was performed to better understand possible interactions between these two systems. Methods Erythrocyte superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GSH‐Px) activity were evaluated 15 (aged 11/2–15 years) IDA. enzyme determined spectrophotometrically. Platelet aggregation secretion studies using impedance...
Considerable differences exist for the spectrum of GJB2 mutations in different populations. Screening c.35delG mutation 256 independent probands, 154 multiplex (familial) and 102 simplex (sporadic), coming from regions Turkey revealed 37 (14.5%) homozygotes. The allele frequency ranged 5% to 53% cities. Parental consanguinity was noted 34% homozygotes, yet it 55% negatives (p=0.034). Further screening families demonstrated presence c.167delT L90P as well a novel complex mutation,...
Inherited gene defects related to the coagulation system have been reported as risk factors for ischemic stroke. These include a G-A transition at nucleotide 1691 in exon 10 of Factor V causing activated protein C resistance; 3' untranslated region prothrombin position 20210 (G-A), which is associated with increased levels activity; and C-T polymorphism 677 methylenetetrahydrofolate reductase responsible an alanine valine substitution, resulting synthesis thermolabile form that causes...