A5076123561- Zebrafish Biomedical Research Applications
- Telomeres, Telomerase, and Senescence
- Genetics, Aging, and Longevity in Model Organisms
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Hepatitis C virus research
- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Cancer-related Molecular Pathways
- Genomics and Chromatin Dynamics
- Aquaculture disease management and microbiota
- Erythrocyte Function and Pathophysiology
- Digital Holography and Microscopy
- Single-cell and spatial transcriptomics
- Electromagnetic Scattering and Analysis
- Viral gastroenteritis research and epidemiology
- Environmental Science and Water Management
- DNA Repair Mechanisms
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Nicotinic Acetylcholine Receptors Study
Bilkent University
2006-2023
Hacettepe University
2017-2020
Ankara University
2005-2013
University of Strathclyde
2010
Senescence is a permanent proliferation arrest in response to cell stress such as DNA damage. It contributes strongly tissue aging and serves major barrier against tumor development. Most cells are believed bypass the senescence (become "immortal") by inactivating growth control genes TP53 CDKN2A. They also reactivate telomerase reverse transcriptase. Senescence-to-immortality transition accompanied phenotypic biochemical changes mediated genome-wide transcriptional modifications. This...
Brain aging is a multi-factorial process due to both genetic and environmental factors. The zebrafish has recently become popular model organism for examining age-related diseases because as in humans they age gradually exhibit cognitive decline. Few studies have examined the biological changes brain that may contribute these declines none them within individuals with respect gender. Our aim was identify main pathways associated across We chose males females from specific groups (young,...
Tumor cells have the capacity to proliferate indefinitely that is qualified as replicative immortality. This ability contrasts with intrinsic control of number cell divisions in human somatic tissues by a mechanism called senescence. Replicative immortality acquired inactivation p53 and p16 INK4a genes reactivation hTERT gene expression. It unknown whether cancer reversible. Here, we show spontaneous induction senescence p53-and -deficient hepatocellular carcinoma cells. phenomenon...
We present a comparative study of scattering from healthy red blood cells RBCs and diseased with deformed shapes. Scattering problems involving three-dimensional are formulated accurately the electric magnetic current combined-field integral equation solved efficiently by multilevel fast multipole algorithm. compare cross section values obtained for different RBC shapes orientations. In this way, we determine strict guidelines to distinguish diagnose various diseases using values. The...
No data exist to assess certain polymorphisms that have a potential effect on the immune response in patients with chronic hepatitis delta (CHD). The aim of this study was investigate 6 polymorphic sites: IL-10 -1082 (rs1800896), -627 (rs1800872), IFN-γ +874 (rs62559044), TNF-α -308 (rs1800629), vitamin D receptor (VDR) FokI (rs2228570) and VDR TaqI (rs731236). genotypes 67 CHD 119 B (CHB) were compared. In addition, 56 individuals resolved virus (HBV) infection used as control group for...
In this study, we designed and developed a novel low-cost system for anesthetizing injecting adult zebrafish. The utilizes gradual cooling method the anesthesia maintains fish in stable anesthetic plane, as well stabilizes animal so that intraperitoneal injections can be consistently performed. It is any laboratory with access to workshop build their group. Moreover, it safe researchers, reliable one repeated experiments since multiple injected quickly there little physical contact necessary...
Telomerase is reactivated in the majority of cancers. For instance, gliomas, it common that TERT promoter mutated. Research on telomere GC islands have been focused primarily proximal but little known about distal promoter. Therefore, this study, we investigated and promoter, terms DNA methylation. We did bisulfite sequencing zebrafish tissue samples for tert In brain tissues, identified a hypomethylation site found was associated with aging shortened telomeres. Through directed mutagenesis...
Interventions targeting cholinergic neurotransmission like acetylcholinesterase (AChE) inhibition distinguish potential mechanisms to delay age-related impairments and attenuate deficits related neurodegenerative diseases. However, the chronic effects of these interventions are not well described.
Peroxisome proliferator-activated receptor alpha (PPARalpha) plays important roles in lipid metabolism. A recently discovered L162V polymorphism of the PPARalpha gene is associated with enhanced transcriptional activity. In this study, frequency was investigated nonalcoholic steatohepatitis (NASH) and genotype 1 hepatitis C virus (HCV)-related liver steatosis.Seventy-two NASH 141 HCV-infected patients (54 steatosis, 87 without steatosis) 119 healthy controls were included. analyzed by...
We present rigorous solutions of scattering problems involving healthy red blood cells (RBCs) and diseased RBCs with deformed shapes. Scattering cross-section (SCS) values for different RBC shapes orientations are obtained accurately efficiently using a sophisticated simulation environment based on the electric magnetic current combined-field integral equation multilevel fast multipole algorithm. Using SCS values, we determine strict guidelines to distinguish from diagnose related diseases.