A5034756289- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related Molecular Pathways
- Pediatric Hepatobiliary Diseases and Treatments
- Blood properties and coagulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Corneal Surgery and Treatments
- Pancreatitis Pathology and Treatment
- Cancer Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Alcohol Consumption and Health Effects
- Drug Transport and Resistance Mechanisms
- Microtubule and mitosis dynamics
- Lipid metabolism and disorders
- Inflammatory mediators and NSAID effects
- Metabolism and Genetic Disorders
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Corneal surgery and disorders
- Angiogenesis and VEGF in Cancer
- Organ Transplantation Techniques and Outcomes
Gazi University
2012-2023
Ankara University
2023
Sivas State Hospital
2014
Pediatric Oncology Group
2014
Tissue Regeneration Systems (United States)
2002
Hacettepe University
2001
Tulane University
1992
Significance Liver disease of unknown cause represents an unmet medical need. Using exome sequencing, we describe a syndrome associated with homozygous loss Acyl CoA Oxidase 2 ( ACOX2 ) featuring elevated transaminase levels, liver fibrosis, ataxia, and cognitive impairment. encodes the peroxisomal branched-chain acyl-CoA oxidase is involved in bile acid biosynthetic pathway. Importantly, this disorder potentially reversible, because synthetic pathway can be suppressed exogenous acids,...
Despite advances in the diagnosis and management of idiopathic noncirrhotic portal hypertension, its pathogenesis remains elusive. Insight may be gained from study early-onset familial which Mendelian mutations account for disease. We performed exome sequencing eight subjects six kindreds with onset hypertension indeterminate etiology during infancy or childhood. Three two consanguineous families shared identical rare homozygous p.N46S mutation DGUOK, a deoxyguanosine kinase required...
Abstract Background: Insulin resistance (IR) is commonly associated with non‐alcoholic steatohepatitis (NASH). Peroxisome proliferator‐activated receptor‐α (PPAR‐α) may also play a role in the pathogenesis of NASH. A pivotal NASH depends on hypothesis increased oxidative stress. The aim our study was to evaluate effects supplemental oral vitamin E, potent antioxidant, liver functions, PPAR‐α expression and IR patients Methods: Nine biopsy‐proven were given E 800 mg daily for 24 weeks. Liver...
Nonalcoholic fatty liver disease (NAFLD) is a multisystem and significantly associated with obesity, insulin resistance, type 2 diabetes mellitus, metabolic syndrome, cardiovascular disease.NAFLD has become the most prevalent chronic in Western countries, proportion of NAFLD-related cirrhosis among patients on transplantation waiting lists increased.In light accumulated data about NAFLD, to provide common approach multi-disciplines dealing subject, it necessary create new guidance for...
Liver biopsy is recommended in the majority of patients with chronic viral hepatitis for fibrosis evaluation. Because disadvantages liver biopsy, many studies related to non-invasive biomarkers and scores have been performed. In this study, we aimed assess diagnostic value serum direct markers models predict treatment-naive B (CHB) compare their performance. This study included 58 a diagnosis CHB virus infection 30 healthy controls. Hyaluronic acid, tissue inhibitor matrix metalloproteinase...
p.R375W (Fibrinogen Aguadilla) is one out of seven identified mutations (Brescia, Aguadilla, Angers, Al du Pont, Pisa, Beograd, and Ankara) causing hepatic storage the mutant fibrinogen γ. The Aguadilla mutation has been reported in children from Caribbean, Europe, Japan, Saudi Arabia, Turkey, China. All presented with a variable degree histologically proven chronic liver disease low plasma levels. In addition, Japanese Turkish child had concomitant hypo-APOB-lipoproteinemia unknown origin....
Simple, reproducible and non-invasive tests that can be used to determine the severity of non-alcoholic steatohepatitis (NASH) are needed. Liver-type fatty acid binding protein (L-FABP) plays a key role in metabolism liver. We aimed whether serum L-FABP levels patients with NASH were different from those healthy controls, if so, this was associated degree fibrosis, steatosis inflammatory activity.Forty-seven histologically confirmed 41 controls included study. Serum measured all...
Genetic polymorphisms may play role in the pathophysiology of nonalcoholic steatohepatitis (NASH).We purposed to assess interleukin 6 (IL 6) and 8 8) gene pathogenesis NASH.Consecutive patients with biopsy proven NASH age- gender-matched healthy individuals normal liver function tests ultrasonography were enrolled study. Histopathological findings recorded according fatty disease activity score (NAS). Patients classified fibrosis scores as < 2 (mild group) ≥ (significant group). Blood...
The role of transforming growth factor β1 (TGF β1) in airway remodeling asthma and chronic obstructive pulmonary disease (COPD) has not been fully described. To evaluate the possible pathogenetic TGF COPD, immunohistochemical expression was described bronchial biopsies from patients with COPD compared healthy individuals. Twelve subjects asthma, 13 10 individuals enrolled study. Bronchial were stained hematoxylin eosin anti‐TGF antibody. As a result, immunoreactive mainly localized...
<i>Purpose:</i> To evaluate the keratocyte apoptosis and effects of topical vitamin E on after photorefractive surgery. <i>Methods:</i> Rabbits were divided into 7 groups, all groups compared with controls epithelial scraping, scrape keratectomy (PRK) (traditional PRK), transepithelial PRK, production a corneal flap microkeratome laser-assisted in situ keratomileusis (LASIK). The Vitamin treatment investigated traditional PRK group. terminal deoxyribonucleotidyl...
Regular follow-up of patients with lung cancer treated surgically is crucial to detect local recurrence or distant metastasis the tumor. Postoperative follow-ups are performed thorax computed tomography (CT) and, if necessary, positron emission (PET)/CT. Sometimes, inflammatory tissue reactions due materials used during surgery for hemostasis may cause appearance tumor in imaging modalities. In this study, we presented that oxidized regenerated cellulose (ORC) intraoperatively false on...
Autoimmune hepatitis (AIH) is a rare, immune-mediated liver disease. It has heterogeneous nature with varied clinical presentations. The management of patients AIH challenging in many ways. main difficulties are inexperience due to the rarity disease, diagnostic confusion controversial areas such as variant/overlap cases, acute presentations, presence non-alcoholic fatty disease or drug-induced injury features, and long complex course treatment. Here, we provide clear, concise, visualized...
We investigated the relation of expression tumor-suppressor gene product p53, apoptosis-regulator bcl-2, and CD34 (as a measure microvessel density [MVD]) with traditional clinicopathologic prognostic variables in endometrial carcinoma (histologic type, grade, depth myometrial invasion, angiolymphatic lymph node involvement). In specimens from 63 patients carcinoma, mean MVD (64.38±28.71 microvessels per 200× field) was not related to any variables. Nuclear p53 detected 15 (23.8%) higher...