A5025438476- Neutropenia and Cancer Infections
- Hematological disorders and diagnostics
- Cancer Immunotherapy and Biomarkers
- Nutrition and Health in Aging
- Immunotherapy and Immune Responses
- GDF15 and Related Biomarkers
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Blood disorders and treatments
- Macrophage Migration Inhibitory Factor
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Sarcoidosis and Beryllium Toxicity Research
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Cells and Metastasis
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Nuclear Receptors and Signaling
- Cancer Treatment and Pharmacology
- Vasculitis and related conditions
- Colorectal Cancer Screening and Detection
- Inhalation and Respiratory Drug Delivery
- Patient-Provider Communication in Healthcare
- Oral health in cancer treatment
- Digital Mental Health Interventions
Gazi University
2019-2025
Yenişehir Hospital
2024
ABSTRACT Objective The Prognostic Nutritional Index (PNI), reflects the nutritional and immunological status of patient has been associated with outcomes in various cancers. In this study, prognostic significance PNI metastatic hormone‐sensitive prostate cancer (mHSPC) its potential role guiding treatment decisions between abiraterone acetate enzalutamide is investigated. Methods Retrospective analysis was performed on 167 mHSPC patients treated 2019 2024. calculated using formula: 10 ×...
Growth differentiation factor-15 (GDF-15), a member of the TGF-β superfamily, is overexpressed in various cancers and facilitates immune evasion by inhibiting T-cell activation. GDFATHER-TRIAL's phase 2a results demonstrated promising outcomes when combining GDF-15 neutralizing antibody visugromab (CTL002) with nivolumab, enhancing response to immunotherapy. This study evaluated prognostic significance expression non-small cell lung cancer (NSCLC) tumor tissues terms immunotherapy response....
Immune checkpoint inhibitors (ICIs) can trigger immune-related adverse events (irAEs). The appearance pattern of irAEs, who is prone to them, and their mechanisms are still uncertain. In this study, we aimed monitor patients initiated on ICIs for endocrinological aspects investigate the potential predictive markers in development endocrine-irAEs. study prospectively included 43 with metastatic disease scheduled anti-PD-1/L1 therapy. Endocrinological follow-up was conducted at specified...
Background: PD-L1 and VISTA are important checkpoint control stations play an immunomodulatory role in patients with non-small-cell lung cancer. Method: The expression levels of between pre- post-treatment tumor tissue were compared. Results: While was >1% 35% before neoadjuvant therapy, 65% after treatment (p = 0.004). 41% treatment, this rate 0.025). Conclusion: Chemotherapy chemoradiotherapy can be used as immunizers by increasing levels.
Objectives The aim of this study was to evaluate the effect serum albumin/globulin ratio (AGR) on 30-day mortality febrile neutropenia (FEN). second combination AGR with Multinational Association for Supportive Care in Cancer (MASCC) and Clinical Index Stable Febrile Neutropenia (CISNE) risk indexes FEN. Methods A retrospective evaluating AGR, MASCC CISNE scores FEN mortality. Results total 137 episodes 120 patients were included study. Nineteen (14%) died within first 30 days episodes. rate...
We investigated expressions of PD-L1, LAG-3, TIM-3, and OX40L as immune checkpoint proteins, MSI (repetitive short-DNA-sequences due to defective DNA-repair system) status were analyzed with immunohistochemistry from tissue blocks. Of 83 patients, PD-L1 expression was observed in 18.1% (n = 15) the patients. None patients exhibited LAG-3 expression. TIM-3 4.9% 4), 22.9% 19), 8.4% 7) had tumor. A low-to-intermediate positive correlation between (rho: 0.333, p < 0.01). Although higher grade 3...
Total neoadjuvant therapy (TNT) has emerged as a promising approach for managing locally advanced rectal cancer (LARC), aiming to enhance resectability, increase pathological complete response (pCR), improve treatment compliance, survival, and sphincter preservation. This study compares the clinical outcomes of TNT, with either induction or consolidation chemotherapy, those standard chemoradiotherapy (CRT). In this retrospective multi-institutional study, patients stage II-III LARC who...
Background: Immunotherapy has transformed cancer treatment; however, predicting treatment response remains challenging. Serum biomarkers can help identify patients who are most likely to benefit from immunotherapy. Objective: This study evaluates the relationship between serum growth differentiation factor 15 (GDF-15) and interleukin-6 (IL-6) levels outcomes in undergoing second-line Methods: We conducted a prospective observational involving 85 with non-small-cell lung (NSCLC), renal cell...
Objective: Rectal bleeding is one of the most important symptoms colorectal cancer that fast-tracks patient’s consultation with a physician. This study aims to assess warning role rectal in risk group for cancer. Besides, relationship among awareness, various socio-demographic criteria and reasons visiting or not physician was evaluated greater than equal 40 years old. Methods: descriptive conducted thousand hundred sixteen (1116) individuals old. Awareness as sign participating assessed by...
Objective: Discussions regarding the treatment of stage III non-small cell lung cancer (NSCLC) are still ongoing in literature. It is important to evaluate developments radiotherapy and surgery along with data real life NSCLC. The aim this study approaches real-life IIIA IIIB local advanced Method: files 47 patients NSCLC, who were followed up Gazi University Faculty Medicine, Medical Oncology Clinic between February 2016 May 2018, retrospectively evaluated. Results: As primary treatment,...