A5103267801- Endometrial and Cervical Cancer Treatments
- Colorectal and Anal Carcinomas
- Cervical Cancer and HPV Research
- Sarcoidosis and Beryllium Toxicity Research
- Epigenetics and DNA Methylation
- Anorectal Disease Treatments and Outcomes
- Cancer Treatment and Pharmacology
- Childhood Cancer Survivors' Quality of Life
- Bone health and treatments
- Autoimmune and Inflammatory Disorders
- Colorectal Cancer Surgical Treatments
- Histone Deacetylase Inhibitors Research
- Advanced Breast Cancer Therapies
Sakarya University
2021-2024
Objective To investigate the impact of cumulative cisplatin dose on clinical outcomes in locally advanced cervical cancer patients undergoing definitive chemoradiotherapy. Methods A retrospective analysis was conducted 654 with stage IB3–IVA disease treated Radiotherapy applied as external beam pelvic or without para-aortic radiotherapy and brachytherapy. Concomitant chemotherapy form weekly 3 cisplatin. Data demographics, treatment protocols, dose, adverse effects, survival were collected....
e17534 Background: This multicentric study aimed to investigate the impact of cumulative cisplatin dose on clinical outcomes in locally advanced cervical cancer patients undergoing definitive chemoradiotherapy (CRT). Methods: A retrospective analysis was conducted 654 with stage IB3-IVA disease treated CRT. Radiotherapy (RT) applied as external beam pelvic or without para-aortic RT and brachytherapy. Concomitant chemotherapy form weekly 3-weekly cisplatin. Data demographics, treatment...
Background: Sarcoidosis is a systemic granulomatous disease. In its pathology, it thought that 1-alpha hydroxylase production and activation as well 1,25-hydroxy vitamin D from active macrophages take place. FGF-23 alpha klotho are proteins play key role in the bone-parathyroid-kidney axis, regulation of phosphate calcium metabolism, metabolism. We aimed to demonstrate effects pathologic conditions on bone metabolism occurrence vascular calcification since can be activated non-kidney...
Total neoadjuvant therapy (TNT) has emerged as a promising approach for managing locally advanced rectal cancer (LARC), aiming to enhance resectability, increase pathological complete response (pCR), improve treatment compliance, survival, and sphincter preservation. This study compares the clinical outcomes of TNT, with either induction or consolidation chemotherapy, those standard chemoradiotherapy (CRT). In this retrospective multi-institutional study, patients stage II-III LARC who...
Epigenetics is the science of biology that studies gene expression changes, which are not caused by changes in DNA sequence, but also inherited. The molecular basis epigenetics a complex phenomenon and determines when how certain genes activated. Cancer characterized as disease cells reproduce uncontrollably then spread. multifactorial accumulation genetic and/or epigenetic changes. Epigenetic mechanisms include methylation, histone modifications, noncoding ribonucleic acid regulation....