A5058504269- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Treatments and Studies
- Advanced Breast Cancer Therapies
- Orthopaedic implants and arthroplasty
- Breast Cancer Treatment Studies
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Hip disorders and treatments
- Lung Cancer Treatments and Mutations
- Renal cell carcinoma treatment
- Orthopedic Infections and Treatments
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Gastrointestinal Tumor Research and Treatment
- PARP inhibition in cancer therapy
- HER2/EGFR in Cancer Research
- Hip and Femur Fractures
- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Endometrial and Cervical Cancer Treatments
Hacettepe University
2021-2025
Niğde Ömer Halisdemir Üniversitesi
2024-2025
Hacettepe University Hospital
2020-2024
Weatherford College
2023
Cancer Institute (WIA)
2022-2023
Gazi Hastanesi
2021
Marmara University
2021
Akdeniz University
2021
Capital Health
2021
Regional Medical Center
2021
The objective of this study was to explore the possible association between low skeletal muscle mass (SMM)—assessed by computed tomography (CT) and ultrasound (US)—and hematologic toxicity in cancer patients. A prospective cohort conducted patients who received anthracycline-based chemotherapy 2018 2020 had baseline abdominal CT including L3 level for measuring SMM. Regional measurements were carried out using US. total 65 (14 males, 51 females) included. ROC (receiver operating...
Dynamic changes in the blood-based biomarkers could be used as a prognostic biomarker patients treated with immune checkpoint inhibitors (ICIs), although data are limited. We evaluated association between neutrophil−lymphocyte ratio (NLR) and early NLR survival ICI-treated patients. retrospectively of 231 advanced-stage cancer. recorded baseline clinical characteristics, fourth-week changes, data. A compound score, NLR2-CEL was developed following parameters: (<5 vs. ≥5), ECOG status (0 ≥1),...
Background Dynamins are defined as a group of molecules with GTPase activity that play role in the formation endocytic vesicles and Golgi apparatus. Among them, DNM3 has gained recognition oncology for its tumor suppressor role. Based on this, aim this study is to investigate effects gene patients diagnosed pancreatic cancer using bioinformatics databases.
Background: Metastatic bladder cancer (mBC) presents a significant global health challenge with poor prognosis and considerably limited survival. Despite advancements in therapies, long-term survival remains difficult to predict. This study aimed evaluate the prognostic potential of various pretreatment blood-based biomarkers, including NLR, dNLR, LMR, PLR, SII, mGPS, CAR, AGR, PNI, PIV, Bellmunt score, mBC patients. Methods: A retrospective cohort 133 patients from Hacettepe University...
The aim of this study was to investigate the prevalence maxillary lateral incisor (MLI) agenesis and associated dental anomalies as well skeletal patterns in an orthodontic population, then compare it with these general population.The material present included records 3872 patients. followings were recorded for each subject MLI: Age, sex, unilateral or bilateral absence, anterior-posterior relationship maxilla mandible, presence anomalies. occurrence compared data previously reported...
The aim of this study was to assess the impact coronaphobia on treatment and follow-up compliance in cancer patients. records 230 patients were reviewed. Coronaphobia assessed via validated COVID-19 Phobia Scale (C19P-S). A total 64% had a high score. Among them, 59% noncompliant. In multivariate logistic regression analysis, low educational status, type, following news, having knowledge about transmission higher C19P-S score associated with noncompliance (p = 0.006, p < 0.001, 0.002, 0.002...
The only phase 3 study on the effectiveness of CDK 4-6 inhibitors in first-line treatment premenopausal patients with hormone receptor (HR) positive, HER2 negative metastatic breast cancer is MONALEESA-7 study, and data palbociclib limited. Data are also limited regarding whose dose was reduced due to neutropenia, most common side effect inhibitors. In our we aimed evaluate ribociclib reduction neutropenia progression-free survival. Our a multicenter, retrospective factors affecting survival...
Total hip arthroplasty in dislocated developmental dysplasia is a complex, technically demanding procedure with high complication rates. Anatomic abnormalities and the young age of patients influence results. Restoration anatomic center often requires shortening femur order to avoid over-stretching neurovascular structures. We performed cementless total subtrochanteric transverse osteotomy on 44 hips 31 patients. There were 29 female 2 male The average at time operation was 43.2 (range,...
People socialize and receive education training for the first time outside home at school, where their teachers act as role models. Teachers play a crucial in instilling sun-protection habits children. Avoiding sun between 10 a.m. 4 p.m., staying shade, wearing sun-protective clothing, sunglasses, hats, using sunscreen products, an umbrella are some of methods described literature. This study sought to assess teachers' skin cancer knowledge attitudes (SC).In this cross-sectional conducted 21...
Aim: To assess the prognostic role of CA-125 elimination rate constant K (KELIM) score in platinum-resistant/refractory ovarian cancer patients receiving second-line treatment. Methods: A retrospective study was carried out including 117 with advanced-stage treated liposomal doxorubicin ± bevacizumab. The KELIM score, calculated using measurements within first 100 days chemotherapy, used. Survival analyses were performed for overall survival (OS) and progression-free (PFS). Results: Higher...
This study addresses the gap in understanding prognostic relevance of hypoxia-inducible factor-1 alpha (HIF-1 alpha) expression metastatic cervical squamous cell carcinoma (SCC) patients undergoing anti-vascular endothelial growth factor (VEGF)-based therapy. A retrospective multicenter (n = 34) explored HIF-1 via immunohistochemistry treated with platinum chemotherapy and bevacizumab. Median progression-free survival (PFS) was significantly lower low score group compared to high (4.9 vs...
Aim Sirolimus, a mammalian target of rapamycin inhibitor, inhibits cell growth and proliferation by controlling ribosome biogenesis protein synthesis in vascular anomalies cancers. However, most sirolimus studies on were conducted the pediatric population, with limited data adults. In this study, we assessed effectiveness safety adult patients malformation, subtype anomaly. Methods We retrospective analysis malformation aged over 16, treated at Hacettepe University Cancer Institute from...
To investigate the impact of cumulative cisplatin dose on clinical outcomes in locally advanced cervical cancer patients undergoing definitive chemoradiotherapy. A retrospective analysis was conducted 654 with stage IB3-IVA disease treated Radiotherapy applied as external beam pelvic or without para-aortic radiotherapy and brachytherapy. Concomitant chemotherapy form weekly 3 cisplatin. Data demographics, treatment protocols, dose, adverse effects, survival were collected. Statistical...
e17534 Background: This multicentric study aimed to investigate the impact of cumulative cisplatin dose on clinical outcomes in locally advanced cervical cancer patients undergoing definitive chemoradiotherapy (CRT). Methods: A retrospective analysis was conducted 654 with stage IB3-IVA disease treated CRT. Radiotherapy (RT) applied as external beam pelvic or without para-aortic RT and brachytherapy. Concomitant chemotherapy form weekly 3-weekly cisplatin. Data demographics, treatment...