A5030982886- Breast Cancer Treatment Studies
- Inflammatory Biomarkers in Disease Prognosis
- Advanced Breast Cancer Therapies
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Prostate Cancer Treatment and Research
- Cancer Treatment and Pharmacology
- Palliative Care and End-of-Life Issues
- Chronic Lymphocytic Leukemia Research
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Family Support in Illness
- Bone health and treatments
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Male Breast Health Studies
- Gastric Cancer Management and Outcomes
- Melanoma and MAPK Pathways
- COVID-19 and healthcare impacts
- Cancer Risks and Factors
Manisa Celal Bayar University
2020-2025
Kent Hastanesi
2021-2022
Şırnak University
2022
Balıkesir University
2022
Izmir University
2021-2022
İzmir University of Economics
2021-2022
Manisa Celal Bayar Üniversitesi Hafsa Sultan Hastanesi
2022
Kent Hospital
2021-2022
Eli Lilly (United States)
2021
Sağlık Bilimleri Üniversitesi
2019
Angiogenesis, an important prognostic factor in several tumours, is a complex event mediated by angiogenic factors released from cancer cells and host immune cells. Among the cells, role has been implicated for mast tumour progression via promoting angiogenesis. Data have recorded that indicate correlation between intratumoral neovascularisation, as assessed microvessel density (MVD), prognosis squamous cell carcinoma (SCC) of oesophagus. However, (MCD) either or angiogenesis not delineated...
There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor (CDK4/6) based therapy. We aimed to evaluate which oncologists prefer patients with disease progression under CDKi. In addition, we show the effectiveness of systemic treatments CDKi and whether there a survival difference between hormonal (monotherapy vs. mTOR-based).A total 609 from 53 centers were included study....
To evaluate prognostic significance of the new index, designed by formulating hemoglobin, albumin, lymphocyte, and platelet (HALP) counts in patients with metastatic renal cell carcinoma (RCC).Descriptive study.Department Medical Oncology, Celal Bayar University, Manisa, Turkey Adnan Menderes Aydin, Turkey, from January 2014 to April 2020.Patients RCC sufficient follow-up data were included study as a retrospective cohort. HALP score was calculated hemoglobin (g/L) × albumin levels...
Ribociclib, palbociclib and abemaciclib are currently approved CDK4/6 inhibitors along with aromatase as the first-line standard-of-care for patients hormone receptor-positive, HER2-negative metastatic breast cancer.
In recent years, significant success has been achieved in the treatment of metastatic melanoma with use immune checkpoint inhibitors (ICIs), and it resulted a remarkable increase patient survival. However, there are only few studies reflecting daily practice outside clinical trials. The present study aimed to evaluate effectiveness safety ICI therapy Turkish patients melanoma, including those poor prognostic factors such as advanced age brain metastasis. A retrospective analysis was...
Abstract Background Cancer patients are in the high-risk group of getting COVID-19 infection and experiencing a severe course. Anxiety cancer about how they pass this pandemic process changes health system would influence their treatment has increased together with pandemic. Influence on psychology is also subject needed to be investigated as well its course prognosis. Thus, it aimed measure fear levels by validated scale. Patients accepting fill Fear (FCV-19S) scale were included our study....
Background: Clinical trials in metastatic hormone receptor-positive (HR+) human epidermal growth factor receptor-2 (HER2)-negative patients have shown that cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors both increase response rates and provide survival benefits. The efficacy of these therapies needs to be supported by real-life data. In this study, we aimed evaluate treatment response, affecting factors with HR+/HER2− breast cancer (MBC) who were followed up CDK our center. Materials...
In this Turkish Oncology Group study, we aimed to evaluate the effectiveness of trastuzumab emtansine (TDM1) in adjuvant treatment early-stage human epidermal growth factor receptor-2 (HER2)-positive breast cancer with residual disease using real-life data. A total 13 centers participated study between September 2019 and October 2024. Patients HER2-positive who underwent surgery after completing neoadjuvant chemotherapy HER2-targeted therapies had invasive or axillary lymph nodes received...
Clinical studies aimed at identifying effective and simple prognostic markers for gastric cancer are still being carried out. Inflammatory index (IPI) is recognized as a promising marker in patients with Non-Small Cell Lung Cancer. To evaluate the utility of IPI stage 4 cancer. A total 152 cancer, whose laboratory parameters, progression-free survival (PFS) overall (OS) data could be accessed, were evaluated. Kaplan Meier analysis was used analyses. Hazard ratios expressed 95% CI values. All...
<b><i>Background:</i></b> Triple-negative breast cancer (TNBC) has none of the targeted treatment choices due to its distinct biological property, making this subtype a unique disease. In study, we evaluated impact obesity on clinical outcomes TNBC. <b><i>Methods:</i></b> The data patients admitted our department were collected. TNBC was defined as lack estrogen receptor (ER), progesterone (PR) and HER-2. body mass index (BMI) 112 calculated...
Hepatocellular carcinoma (HCC) is a significant health problem, and the associated mortality rate increasing.We aimed to determine clinical characteristics prognosis for HCC in member countries of OncoBridge Study Group.We recruited 630 patients diagnosed with between 2013 2019 from 4 (Türkiye, Russia, Georgia, Greece). Univariate multivariate analyses were conducted investigate laboratory prognostic factors. Receiver operating characteristic (ROC) analysis was used value neutrophil...
Prostate cancer (PCa) is the most common type of among males. Although survival rate early-stage PCa high, treatment options are very limited for recurrent disease. In this study, possible synergistic cytotoxic and apoptotic effect octreotide in combination with AT-101 was investigated DU-145 hormone drug refractory prostate cell line. To enlighten action mechanisms treatment, expression levels somatostatin receptors 2 5 (SSTR2 SSTR5) were also investigated. Cell viability measured by XTT...
Aggressive fibromatosis (AF), also known as desmoid tumor, is an uncommon soft tissue neoplasm. AF does not metastasize, but it locally invasive and its propensity for recurrence after conservative resection well documented. No effective cytotoxic treatment has been reported, hence there a need novel strategies.We present the case of successfully treated with oral tyrosine kinase inhibitor, pazopanib, mild side effects. As far we know, this first complete response to pazopanib.Pazopanib...
Introduction: Pancreatic adenocarcinoma is one of the deadliest cancers.Effective, simple and practical methods that can be used in daily life are still lacking to predict prognosis patients with advanced pancreatic cancer a promising biomarker needed prognosis.Our study's objective was demonstrate correlation between HALP score metastatic cancer.Methods: Patients diagnosed from 4 centers Turkey 2016 2022 were included.Demographic data, hemogram parameters, biochemistry values, as well...