Nurhan Önal Kalkan

ORCID: 0000-0002-2823-332X
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About
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Research Areas
  • Breast Cancer Treatment Studies
  • Advanced Breast Cancer Therapies
  • Cancer-related Molecular Pathways
  • Gastric Cancer Management and Outcomes
  • Lung Cancer Treatments and Mutations
  • Esophageal Cancer Research and Treatment
  • Radiopharmaceutical Chemistry and Applications
  • Cardiovascular and Diving-Related Complications
  • Neonatal Health and Biochemistry
  • Colorectal Cancer Surgical Treatments
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Advanced biosensing and bioanalysis techniques
  • HER2/EGFR in Cancer Research
  • Colorectal Cancer Treatments and Studies
  • Bone health and treatments
  • Cancer Immunotherapy and Biomarkers
  • Thyroid Disorders and Treatments
  • Cancer Treatment and Pharmacology
  • Inflammatory Biomarkers in Disease Prognosis
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Analytical chemistry methods development
  • Multiple and Secondary Primary Cancers
  • Cancer Diagnosis and Treatment
  • Colorectal and Anal Carcinomas
  • Ovarian cancer diagnosis and treatment

Van Yüzüncü Yıl Üniversitesi
2016-2025

Batman University
2025

Kocaeli Üniversitesi
2022

Ribociclib, palbociclib and abemaciclib are currently approved CDK4/6 inhibitors along with aromatase as the first-line standard-of-care for patients hormone receptor-positive, HER2-negative metastatic breast cancer.

10.2217/fon-2022-1287 article EN Future Oncology 2023-03-01

Background: In recent years, reducing adjuvant treatment period from 6 months to 3 in low‐risk stage colon cancer has shown no decline efficiency and fewer adverse effects, particularly neuropathy. Aim: We examined the efficacy side effects of 3‐ 6‐month chemotherapy regimens patients. Methods: Twelve oncology centers retrospectively scanned operated, low‐risk, (T1‐3, N1) Capecitabine oxaliplatin (CAPOX) were given all 3‐month patients, while patients received FOLFOX orCAPOX. Two groups...

10.4103/njcp.njcp_848_23 article EN Nigerian Journal of Clinical Practice 2025-02-01

Highly selective inhibitors of cyclin-dependent kinase 4 and 6 (CDK4/6is) have emerged as a standart care for first- second-line therapies in combination with endocrine therapy (ET) HR+/HER2- metastatic breast cancer (MBC) patients. It has been reported that is more effective than ET alone safe elderly patients well young Nevertheless, very old HR+/HER2-MBC treated CDK4/6 inhibitor (CDK4/6i) combinations are relatively underrepresented randomized controlled trials. To contribute to the...

10.1186/s12885-024-13357-5 article EN cc-by-nc-nd BMC Cancer 2024-12-30

In our study, we aimed to evaluate the pathological response rates and side effect profile of adding pertuzumab treatment HER2+ locally advanced, inflammatory, or early-stage breast cancer. This study was conducted by Turkish Oncology Group (TOG) with data collected from 32 centers. Our multicentric, a total 364 patients were included. The median age 49 years (18-85 years). Two hundred fifteen (60%) cases hormone receptor/HER2+ positive(ER+ PR+, both), 149 (40%) them HER2-rich (ER PR...

10.1097/cad.0000000000001310 article EN Anti-Cancer Drugs 2022-06-15

A 62-year-old female patient received adjuvant chemotherapy after a mastectomy due to locally advanced invasive ductal carcinoma eight years ago. During the follow-up, she complained of extensive backache, so plain radiography was taken. The showed diffuse lytic lesions located primarily around vertebrae and sternum. Given that bone could be related osseous metastases breast cancer, scintigraphy performed no positive involvement observed. Magnetic resonance imaging subsequently applied...

10.12691/ajcp-4-2-3 article EN Journal of Cancer Prevention 2016-07-19

Tumour Lysis Syndrome (TLS) is an important oncological emergency case which often found together with haematological malignities and, much less often, solid tumours. While TLS seen in tumour cases usually develops following a cytotoxic chemotherapy and its prognosis poor. We present the of 60-year-old man gastric adenocarcinoma diffuse liver metastases (image shows metastatic lesions) high serum LDH levels, who developed after systemic chemotherapy. With urgent proper supportive treatment...

10.4236/jct.2018.91003 article EN Journal of Cancer Therapy 2018-01-01

BACKGROUND Previous studies have indicated that definitive chemoradiotherapy and upfront surgery comparable survival rates, is a more applicable treatment option in resectable locally advanced esophageal squamous cell cancer (ESCC). We compared to for ESCC patients who denied the standard approach, receiving or surgery. MATERIALS AND METHODS One hundred eighty eight locoregional with thoracic distal involvement had were those received but declined surgery, although their tumor was at...

10.5455/annalsmedres.2024.09.183 article EN cc-by-nc-nd Annals of Medical Research 2024-01-01

Van GirişTüm over malignensileri içinde seks kord stromal tümörlerin oranı %5-8'dir (1).Seks tümörlerinin yaklaşık %70'ni oluşturan granüloza hücreli tümörler her 100.000kadının 0.4-1.7'sindegörülür (2).Granüloza tümörleri kordlarından ve stroma veya mezenkiminden köken alırlar.Tümörün başlangıç yaşı histolojik özelliklerine göre bu tümör adult ÖZET Amaç: Granüloza (GHT), overin epitelyal tümörlerine kıyasla nadir görülen daha iyi prognozlu düşük gradeli kaynaklı tümörleridir.Tüm...

10.5505/vtd.2017.63634 article TR cc-by-nc Van Medical Journal 2017-01-01

As the most common liver disease in recent years, nonalco holic fatty (NAFLD) has gained great importance.In a close relationship with insulin resistance been shown pathogenesis of NAFLD and its severe form, NASH.This study aimed to observe effects proton pump inhibitors (PPIs) on hepatosteatosis by causing hypergastrinemia.Forty-two patients diagnosed steatohepatitis were included study.Seventeen 42 followed up dietary therapy alone, 25 diet+PPI for 2 months due accompanying dyspeptic...

10.5505/ejm.2022.03274 article EN Eastern Journal Of Medicine 2022-01-01

Abstract Background : Inflammation plays a pivotal role in cancer development and prognosis. Peripheral blood test is useful parameter the evaluation of systemic inflammatory response. Previous studies have shown relationship between monocyte count prognosis some solid tumors. The aim this study was to evaluate assessed at diagnosis disease-free survival patients with esophageal cancer. Materials Methods: retrospective included 145 who presented Van Training Research Hospital Medical...

10.21203/rs.3.rs-1117468/v1 preprint EN cc-by Research Square (Research Square) 2021-12-06
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