A5055289601- Ear Surgery and Otitis Media
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Head and Neck Surgical Oncology
- Breast Cancer Treatment Studies
- Sarcoma Diagnosis and Treatment
- Ear and Head Tumors
- Cancer Immunotherapy and Biomarkers
- Nasal Surgery and Airway Studies
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Renal cell carcinoma treatment
- Colorectal Cancer Treatments and Studies
- Head and Neck Anomalies
- Cancer Treatment and Pharmacology
- Sinusitis and nasal conditions
- Hearing, Cochlea, Tinnitus, Genetics
- Salivary Gland Tumors Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Bone Tumor Diagnosis and Treatments
- Head and Neck Cancer Studies
- Advanced Breast Cancer Therapies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Chemical Sensor Technologies
- Trauma Management and Diagnosis
Marmara University
2010-2025
Istanbul Medipol University
2024-2025
University of Pittsburgh
2025
Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
2020-2023
Istanbul University
2013-2020
Ministry of Health
2019
Pamukkale University
2014
Marmara Üniversitesi Eğitim ve Araştırma Hastanesi
2010
Trakya University
2008
In-Q-Tel
2007
Introduction: CDK 4/6 inhibitors are effectively utilized among patients with hormone-positive, HER-2-negative metastatic breast cancer. The dose reduction for these varies between 35% and 57% across multiple trials. We aim to clarify the characteristics of who had dosage effect this on survival outcomes. Materials Methods: study was designed as a retrospective, multicenter study. Patients received in first-line subsequent treatment settings were grouped based reductions. Progression-free...
Background: Osteosarcoma is a rare but aggressive bone malignancy. Despite advances in multimodal therapy, survival remains suboptimal, highlighting the need for prognostic markers to guide treatment. Methods: This study included 162 osteosarcoma patients who received neoadjuvant chemotherapy followed by surgery between January 2009 and March 2024. Patients either double (cisplatin + doxorubicin) or triple (MAP PEI) chemotherapy. Survival analyses were conducted using Kaplan–Meier curves,...
BackgroundCDK4/6 inhibitors combined with endocrine therapy have significantly improved treatment outcomes for metastatic hormone receptor-positive (HR+) breast cancer patients. However, the impact of low HER2 expression on response and progression-free survival (PFS) remains unclear.MethodsThis multicenter retrospective study included 204 HR+ patients treated a combination CDK4/6 inhibitor therapy. HER2-zero disease was detected in 138 (68%) HER2-low 66 (32%) Treatment-related...
Our aim was to assess the efficacy of adjuvant programmed cell death protein-1 (PD-1) inhibitors and compare other treatments in patients with surgically resected stage III or IV acral melanoma. This study is a multicenter, retrospective analysis. We included 114 malignant melanoma who underwent surgery within past 10 years. analyzed effect on disease-free survival (DFS). The mean follow-up 40 months, during which 69 (59.5%) experienced recurrence. Among participants, 64 (56.1%) received...
In this study, we compared the levels of C-C chemokine receptor type 5 (CCR5), motif ligand (CCL5), platelet-derived growth factor (PDGF), and EphrinA7 (EphA7) in patients with colorectal carcinoma healthy controls order to investigate significance usability these potential biomarkers early diagnosis cancer. The study included 70 40 individuals. CCR5, CCL5, PDGF, EphA7 were measured using ELISA blood samples. PDGF-BB, EphA7, CCL5 significantly higher control group (p < 0.001 for each...
Background and Objectives: Malignant pleural mesothelioma (MPM) is a rare aggressive malignancy with poor prognosis. Identifying reliable prognostic factors crucial for risk stratification optimizing treatment strategies. This study aimed to evaluate the impact of clinicopathologic systemic inflammatory markers on survival outcomes in patients MPM. Materials Methods: retrospective, multicenter included 217 diagnosed MPM between January 2009 March 2024. Data age, gender, histology, disease...
Objective: Kaposi sarcoma (KS) presents as a multifocal angioproliferative disease with distinct four subtypes, including classical, AIDS-related(epidemic), endemic, and iatrogenic. The rarity of the clinically different characteristics subtypes have led to insufficient experience in treatment follow-up. Based on this, we aim investigate clinicopathological features options KS patients treated followed up our clinic. Patients Methods: study included 66 diagnosed by histopathological...
We aimed to explore the correlation between anti-hypertensive treatment and survival rates in patients with metastatic non-small cell lung cancer (mNSCLC). In this study, we analyzed antihypertensive 300 mNSCLC. Retrospective. Medical faculty hospital. investigated relationship who were diagnosed also examined histological type, performance status, gender, age type of medication used survival. Survival difference mNSCLC without treatment. Among receiving concomitant treatment, 107 (35.7%)...
708 Background: This study evaluates the real-world efficacy and safety of avelumab maintenance therapy in metastatic urothelial carcinoma (mUC) patients who have not progressed following first-line platinum chemotherapy, using data from EAP. Methods: The primary endpoint was overall survival (OS), progression-free (PFS) secondary endpoints included safety. PFS OS were estimated by Kaplan-Meier method. Results: One hundred seventeen received at least one cycle Avelumab. median number...
Aim: Muscle-invasive bladder cancer requires systemic treatment due to its high risk of metastasis. However, studies comparing neoadjuvant and adjuvant therapy regimens are currently limited. Our goal in this study was compare the efficacy patients receiving or locally advanced cancer. Material Methods: We retrospectively included 107 from 6 centres who underwent radical cystectomy received perioperative chemotherapy. Patients were divided into 2 categories: (i) chemotherapy (n=54) (ii)...
Sarcopenia, defined as skeletal muscle loss, has been known a poor prognosis factor in various malignant diseases. We aimed to investigate the effect of sarcopenia on patients with metastatic biliary tract cancer (mBTC) who received chemotherapy. retrospectively collected clinic data 70 mBTC. Computed tomography scans were used determine index at third lumbar vertebra level for sarcopenia. Osteopenia was by averaging radiodensity consecutive five vertebrae non-contrast CT scan images....
To analyze the ototoxicity of Burow solution as an otologic preparation.Burow has been used for years in treatment acute or chronic otitis externa and suppurative media. This acidic antibacterial antiedematous properties. Ototoxic effect not known, so current study was designed to observe ototoxic experimentally.Experiments were performed 32 young, male albino guinea pigs (weight, 450-550 g). Twenty animals experimental group divided into 2 groups 10 each. The first received 13% (13%...
Tympanosclerosis is a common sequela of ventilation tube treatment otitis media with effusion causing hearing disability. It associated an increased production free radicals (also known as reactive oxygen species) after myringotomy. Vitamin E scavenger different by working antioxidant. The aim the present study was to evaluate effect vitamin E-coated tympanostomy insertion at quantity in rat tympanic membrane.This prospective, controlled animal consisted male Sprague-Dawley rats divided into...
Actinomycosis is a rare chronic granulomatous disease that involves the upper airway and gastrointestinal tract. Approximately 40-55% of actinomycosis comprises cervicofacial form. It presents challenging clinical diagnostic dilemma because variable presentations in head neck. Herein, we report case presenting as vocal cord nodule healthy 21-year-old man who was not immunocompromised had no other known medical disease.
This study reports a patient having olfactory neuroblastoma complicated by syndrome of inappropriate antidiuretic hormone secretion. Olfactory is rare tumor that begins in the membrane. Only 10 cases have been reported previously. Because nonspecific symptoms, most patients manifest at an advanced stage time diagnosis. may show local invasion and/or distant metastasis. We demonstrated preoperatively clinical and biochemical parameters consistent with turned to normal ranges after treatment....
Objective: The indications, management, and results are discussed in 45 patients who underwent the concurrent functional endoscopic sinus surgery (FESS) rhinoplasty. Study Design: Retrospective clinical study. Patients Methods: There were 27 women 18 men with a mean age of 28 years. had chronic rhinosinusitis 17 nasal polyposis refractory to medical therapy combined procedure by same otolaryngologist. Results: A review our performed between 2000 2005. no lifethreatening severe complications...
Backround . Thyroglossal duct cyst (TDC) is a developmental abnormality of the thyroid gland. Due to embryological remnants tissue located in TDC, same malignant tumors that develop gland can also TDC. Methods We present unique case 39-year-old female with simultaneous de novo papillary carcinoma TDC and Results With suspicion gland, Sistrunk procedure total thyroidectomy central neck exploration was performed. Conclusion The clinician should have high index upon encountering differentiate...