A5088008421- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- TGF-β signaling in diseases
- Caveolin-1 and cellular processes
- Cancer, Lipids, and Metabolism
- Metastasis and carcinoma case studies
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Colorectal Cancer Surgical Treatments
- Ovarian cancer diagnosis and treatment
- Protease and Inhibitor Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Blood Coagulation and Thrombosis Mechanisms
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
Istanbul University
2016-2025
University of Health Sciences Antigua
2024-2025
Sağlık Bilimleri Üniversitesi
2017-2025
Memorial Sisli Hospital
2024
Turkish Society of Hematology
2024
Bakırköy Psychiatric Hospital
2019-2020
Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi
2016-2017
Despite all efforts at management, prognosis of advanced lung cancer is extremely poor, with a median survival time ~1 year. The number patients aged >70 years significantly increased among the patient population. aim this study was to investigate clinical importance age in cancer. Data from 110 histologically confirmed cancer, who were treated and followed up Institute Oncology, University Istanbul, recorded medical charts. There 100 (91%) males 59 (range, 35-88 years). majority had...
ABSTRACT Background: Bone metastasis is rarely seen in colorectal cancer (CRC) patients, and there insufficient data available regarding such cases. The study aimed to identify the prognostic factors characteristics associated with overall survival patients bone metastatic CRC. Method: Data from CRC referred a high-volume tertiary center Turkey, between January 2018 April 2021, were retrospectively collected. records of 150 consecutive treated for metastases due reviewed. Overall curves...
Aim: To determine whether beta-blockers (BBs) improve the overall survival (OS) of patients with metastatic non-small cell lung cancer (NSCLC). Materials and Methods: The medical charts 107 NSCLC were retrospectively assessed. Thirty-five (BB group) using BBs during chemotherapy (CT) compared 72 controls [control=(C) group] who did not use following diagnosis NSCLC. histological tumor subtype, performance status (ECOG), age, gender, smoking status, comorbidities, other medications...
Objective Pancreatic cancer is the type with highest mortality rate worldwide, and despite advances in treatment, molecular biomarkers are needed for both early diagnosis developing targeted therapies improving survival rates this challenging malignancy. In our study, contributions of programmed death-ligand 1 (PD-L1) expression to determination pancreatic subtypes patient prognosis its impact on were investigated. Material Methods Paraffin-embedded tissues from 92 patients diagnosed...
In this study, we compared the levels of C-C chemokine receptor type 5 (CCR5), motif ligand (CCL5), platelet-derived growth factor (PDGF), and EphrinA7 (EphA7) in patients with colorectal carcinoma healthy controls order to investigate significance usability these potential biomarkers early diagnosis cancer. The study included 70 40 individuals. CCR5, CCL5, PDGF, EphA7 were measured using ELISA blood samples. PDGF-BB, EphA7, CCL5 significantly higher control group (p < 0.001 for each...
High BMI is a well-known risk factor for the development and recurrence of several solid tumours, including CRC. Obesity associated with increased levels vascular endothelial growth (VEGF). Bevacizumab main targeted therapy inhibiting tumour angiogenesis by blocking VEGF/VEGF receptor pathway. Elevated VEGF in obese patients might provoke resistance to anti-VEGF therapy. We evaluated efficacy bevacizumab on TTP among mCRC through stratifying them according their BMI. Patients who had been...
Tenascin-C (TNC) is an extracellular matrix protein that expressed at low levels in normal adult tissue but highly around many tumors including ovarian tumors. The objective of this study was to determine the clinical significance serum TNC epithelial cancer (EOC) patients. A total 50 patients with a pathologically confirmed diagnosis EOC were included study. Serum determined by solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) method. Age- and sex- matched 28 healthy controls...
The aim of this study is to evaluate the correlation coagulation tests with various clinicopathological variables and tumor markers among colorectal cancer (CRC) patients.Ninety-four CRC patients were included for evaluation factors, assays marker levels.Metastatic disease was related elevated INR (p= 0.03). Stage III had higher D-dimer values compared stage II Correlation indicated a tendency towards levels CEA than median 0.01). High CA 19-9 also associated 0.007). Elderly age, distant...
Omentin is related with metabolic syndrome and obesity. Pancreatic adenocarcinoma (PA) a lethal obesity-linked malignancy. This study was conducted to investigate the serum levels of omentin in patients PA relationship tumor progression known prognostic parameters.Serum samples were obtained from thirty-three on first admission before any treatment. Age, sex body mass index (BMI) matched 30 healthy controls included analysis. Both measured using enzyme-linked immunosorbent assay (ELISA).The...
Cellular adhesion molecules might be good markers in some types of malignant tumors, useful information diagnosis and prognosis. The objective this study was to evaluate the serum levels epithelial cell molecule (EPCAM) vascular molecule-1 (VCAM-1) ovarian cancer (EOC) patients. Fifty patients were enrolled into study. Serum EPCAM VCAM-1 determined by solid-phase sandwich ELISA method. Age- sex-matched 30 healthy controls included analysis. median age 56.5 years, range 22 83 years. Majority...
Transforming growth factor-beta 1 (TGF-β1) plays an important role in the pathogenesis of multiple malignancies, and its expression also strongly affects outcomes cancer patients. The objective this study was to determine clinical significance serum levels TGF-β1 melanoma A total 60 patients with a pathologically confirmed diagnosis were enrolled into study. Serum concentrations determined by solid-phase sandwich ELISA method. Thirty age- sex-matched healthy controls included analysis....
The transforming growth factor beta 1 (TGFB1) is a regulatory cytokine with both tumor suppressor and tumor-promoting effects in breast cancer (BC) cell lines tissue. Data about level of circulating TGFB1 its prognostic significance BC patients conflicting. objective this study to determine the clinical serum levels patients. We enrolled 96 female histopathologically diagnosed who did not receive chemotherapy (CT) or radiotherapy. Serum were measured by ELISA method compared 30 healthy...
This study aims to report the efficacy and safety of capecitabine plus temozolomide (CAPTEM) across different lines treatment in patients with metastatic neuroendocrine tumors (NETs).
Insulin-like growth factor-1 (IGF-1) and its primary binding protein IGFBP-3 play an important role in cellular proliferation, differentiation, apoptosis many tumors, including ovarian cancer. The objective of this study was to determine the clinical significance serum levels IGF-1 epithelial cancer (EOC) patients. A total 50 patients with a pathologically confirmed diagnosis EOC were enrolled into study. Serum determined by solid-phase sandwich ELISA method. Twenty age- sex-matched healthy...
The purpose of this study was to determine the clinical significance vascular cell adhesion molecule-1 (VCAM-1) and epithelial molecule (EpCAM) in breast cancer (BC) patients. Ninety-six BC patients 30 age- sex-matched healthy controls were enrolled into study. Pretreatment serum markers determined by solid-phase sandwich (enzyme-linked immunosorbent assay (ELISA)). median age at diagnosis 48 years (range 29-80 years). Majority (71 %) had luminal subtype, 38.5 % metastatic disease....
The efficacy and tolerability of modern cytotoxic chemotherapy regimens used in malnourished metastatic colorectal cancer (mCRC) patients is uncertain. aim this study was to investigate the effect malnutrition on overall survival mCRC patients.In multicenter study, demographic, oncologic nutritional data were collected prospectively from patients. Nutritional status evaluated basis NRI (Nutritional Risk Assessment), BMI (Body Mass Index) WL (Weight Loss) before first chemotherapy, after...
Abstract Background The optimal treatment for metastatic colorectal cancer (mCRC) after the second line is still controversial. Regorafenib has been standard of care in this setting as it improved overall survival (OS) compared to placebo. In real-world practice chemotherapy rechallenge also a preferred option even though supporting evidence not enough. We aim compare efficacy regorafenib and 5-fluorouracil-based (5-FU) third mCRC. Methods retrospective multi-institutional trial, mCRC...