A5015315660- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Sarcoma Diagnosis and Treatment
- Blood groups and transfusion
- Cancer Immunotherapy and Biomarkers
- Advanced Breast Cancer Therapies
- BRCA gene mutations in cancer
- Male Breast Health Studies
- Brain Metastases and Treatment
- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Management of metastatic bone disease
- Cancer-related molecular mechanisms research
- Vascular Tumors and Angiosarcomas
- Peptidase Inhibition and Analysis
- Lung Cancer Diagnosis and Treatment
- Cardiac tumors and thrombi
- Polyomavirus and related diseases
- Gastrointestinal Tumor Research and Treatment
Istanbul University
2019-2025
Acıbadem University
2025
İstanbul Başakşehir Çam ve Sakura Şehir Hastanesi
2022-2024
Istanbul Metropolitan Municipality
2023-2024
Manisa Celal Bayar University
2022
Trakya University
2022
Ankara University
2011-2022
Sağlık Bilimleri Üniversitesi
2022
Teknoloji Arastirma ve Gelistirme Endustriyel Urunler Bilisim Teknolojileri San Tic
2022
Yeditepe University
2010
Central nervous system (CNS) metastases can be seen at a rate of 30% in advanced stages for patients with non-small cell lung cancer (NSCLC). Growing evidence indicates the predictive roles driver gene mutations development brain (BM) recent years, meaning that oncogene-driven NSCLC have high incidence BM diagnosis. Today, 3rd generation targeted drugs intracranial efficacy, which cross blood-brain barrier, made positive contribution to survival these an increased propensity BM. It is...
Kaposi sarcoma is an angioproliferative disease associated with human herpes virus 8 infection. Classic (CKS) usually develops in older age. Although CKS often does not require systemic therapy, therapy can be administered progressively symptomatic patients. In this real-life study, we purposed to determine effectiveness and safety of weekly paclitaxel the first-line treatment CKS. cross-sectional retrospective analyzed clinical data 44 patients who received between January 2000 December...
ABSTRACT Background: Bone metastasis is rarely seen in colorectal cancer (CRC) patients, and there insufficient data available regarding such cases. The study aimed to identify the prognostic factors characteristics associated with overall survival patients bone metastatic CRC. Method: Data from CRC referred a high-volume tertiary center Turkey, between January 2018 April 2021, were retrospectively collected. records of 150 consecutive treated for metastases due reviewed. Overall curves...
Data regarding the use of rechallenge trastuzumab (RTmab)-based therapies in management heavily pretreated patients with HER2-positive breast cancer (BC) literature are limited. This study aimed to evaluate efficacy trastuzumab-based therapy who experienced disease progression after receiving lapatinib plus capecitabine (LC). In this retrospective study, data thirty three HER2 positive metastatic BC progressed LC treatment and subsequently received were evaluated. Trastuzumab was...
Kaposi sarcoma (KS) is a rare angioproliferative malignancy linked to human herpesvirus 8 infection. While systemic therapy often unnecessary for classic and iatrogenic KS, advanced cases may require chemotherapy. This study aims evaluate the efficacy safety of weekly paclitaxel or oral etoposide as second-line treatments classical sarcoma. We retrospectively analyzed clinicopathological characteristics treatment outcomes 32 patients diagnosed with KS at tertiary cancer center between...
In recent years, significant success has been achieved in the treatment of metastatic melanoma with use immune checkpoint inhibitors (ICIs), and it resulted a remarkable increase patient survival. However, there are only few studies reflecting daily practice outside clinical trials. The present study aimed to evaluate effectiveness safety ICI therapy Turkish patients melanoma, including those poor prognostic factors such as advanced age brain metastasis. A retrospective analysis was...
Background: In this study, we evaluated the changes in clinicopathological features and prognosis patients with thyroid cancer last two decades using Surveillance, Epidemiology, End Results Database (SEER) data. Methods: Data from SEER-12 registry (1992–2021) were analyzed, focusing on diagnosed malignant between 2001 2020. The study population was divided into Cohort 1 (2001–2010) 2 (2011–2020). Cohorts compared regarding prognosis. Results: included 94,892 2020, 39,265 55,627 2. Compared...
Previous studies have observed an association between ABO blood group and risk for certain gastrointestinal malignancies, including pancreatic gastric cancer. However, it is unclear whether there such with colorectal cancer (CRC). In this study, possible relationships groups Rh factor KRAS status in patients CRC were investigated.In 1,620 CRC, examined compared the control of 3,022,883 healthy volunteer donors Turkish Red Crescent 2004 2011. The relationship wild type K-ras was also...
Pancreas cancer (PCa) is one of the mortal types with ranking as fourth leading death in both sexes together. FOLFIRINOX (FFX) and Gemcitabine plus nab-paclitaxel (GNP) are approved first-line metastatic treatment PCa. The aim this study was to compare clinical outcomes, treated FFX GNP Medical records patients diagnosed PCa, from January 2010 December 2020 were analyzed. This a retrospective cohort, multi-institution analysis. focus present efficiency chemotherapy combinations Efficacy had...
The purpose of the study was to assess prognosis HER2-positive metastatic breast cancer patients who received trastuzumab beyond progression and investigate predictors complete response. long-term were included in study. Predictors response analyzed with binary regression analysis. had their trastuzumab-based treatment terminated assessed. Eighty involved for a median 62 months (12-191). A observed 60 (75%) patients. duration development found as 14.8 (2.4-55). In logistic analysis: using...
The efficacy and tolerability of modern cytotoxic chemotherapy regimens used in malnourished metastatic colorectal cancer (mCRC) patients is uncertain. aim this study was to investigate the effect malnutrition on overall survival mCRC patients.In multicenter study, demographic, oncologic nutritional data were collected prospectively from patients. Nutritional status evaluated basis NRI (Nutritional Risk Assessment), BMI (Body Mass Index) WL (Weight Loss) before first chemotherapy, after...
The aim was to assess the prognostic variables in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer patients receiving lapatinib plus capecitabine.Retrospective data on HER2-positive who received and capecitabine were analyzed. Survival outcome obtained with Cox regression analysis Kaplan-Meier method.The study included 102 patients. Forty-four (43.1%) had de novo disease. most frequent sites were, order, bone (61.8%), brain (57.8%), liver (35.3%), lung...
The prognosis of metastatic gastric cancer (GC) is poor, with a median survival time less than year. Capecitabine prodrug, metabolized by thymidine phosphorylase to its cytotoxic metabolite (5-FU). Few studies have compared capecitabine and 5-FU in mGC. In this retrospective study, we the efficacy safety modified DCF (mDCF) (docetaxel, cisplatin, 5-FU) DCX (mDCX) capecitabine) regimens for first-line treatment patients study included 112 mGC treated either mDCF (n = 69) or mDCX 43) between...
Background The possible impact of malnutrition on the efficacy and tolerability modern chemotherapy for metastatic gastic adenocarcinoma (mGC) patients is unclear. With this study, we aimed to represent chemotherapy, also overall survival mGC patients. Methods In prospective multicenter collected demographic, oncological nutritional data our status were assessed with Nutritional Risk Index (NRI), Body Mass (BMI) weight loss percentage within 21-day period, between cycles. All these...
The addition of aflibercept to the fluorouracil and irinotecan (FOLFIRI) regimen significantly improved clinical outcomes in patients with metastatic colorectal cancer (CRC) previously treated oxaliplatin. We aimed investigate efficacy safety second-line FOLFIRI combination CRC real-life experience.
The median survival time for metastatic gastric cancer that has a poor prognosis is usually shorter than 1 year. fluorouracil, oxaliplatin, and docetaxel (FLOT) regimen observed to be effective in the neo-adjuvant treatment of cancer. However, data on FLOT are limited. current study aims evaluate safety efficacy real life.Retrospective study.The was performed an Institute Oncology university included patients diagnosed between January 2015 December 2020.In addition clinicopathological with...
Background: The goal of this research is to investigate the clinical characteristics and prognosis men with metastatic breast cancer (mMBC). Methods: A retrospective analysis data 28 patients was conducted. Kaplan–Meier Cox regression analyses were used assess overall survival (OS) prognostic variables. Results: At time diagnosis, median age 57 years (range 26–86). most prevalent pathological subtype invasive ductal carcinoma (92.6%). HER2 positivity 21.6% in patients, estrogen progesterone...
The goal of the research was to investigate if a combination vincristine, irinotecan and temozolomide (VIT) could benefit adult patients with metastatic Ewing sarcoma who had already been heavily pretreated. Metastatic their data retrospectively analyzed. patients' clinical, radiological therapeutic were recorded. Survival analyzes performed these data. study enlisted participation sixteen patients. average age 25 years old (range: 20-42). lung most prevalent location (81.3%). Patients...