A5065047833- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Lymphoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Cancer Risks and Factors
- Colorectal and Anal Carcinomas
- Male Breast Health Studies
- Appendicitis Diagnosis and Management
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Sarcoma Diagnosis and Treatment
- Omental and Epiploic Conditions
- Lung Cancer Treatments and Mutations
- Kidney Stones and Urolithiasis Treatments
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Cancer Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Sağlık Bilimleri Üniversitesi
2021-2025
Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi
2021-2025
University of Health Sciences Antigua
2024-2025
University of Health Science
2023-2024
University of Health Sciences
2023
Van Yüzüncü Yıl Üniversitesi
2020
Bursa Uludağ Üni̇versi̇tesi̇
2014-2016
Antalya Eğitim ve Araştırma Hastanesi
2013
Abstract Neoadjuvant chemotherapy (NACT) is the standard treatment for locally advanced, high-risk breast cancer. Pathological complete response (pCR) improves survival. Peripheral blood-derived indices reflecting systemic inflammation and nutritional status have long been used as predictive prognostic markers in solid malignancies. This retrospective study investigates whether eight commonly patients receiving NACT affect pCR includes 624 advanced cancer who received NACT. The biomarker...
Neutrophil lymphocyte ratio (NLR) has emerged as a valuable and reliable method for follow-up of systemic inflammatory disease. We herein aimed to evaluate the role NLR in clinical inflammation also compare its relationship with other measures, such erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI).A total 35 active ankylosing spondylitis (AS) 38 healthy volunteers were included study. The patient group was enrolled...
Background and Objectives: Early-onset breast cancer (EOBC), particularly in patients under 40, presents with distinct biological characteristics worse survival outcomes compared to late-onset cases. Despite intensive treatments, EOBC patients, especially those hormone receptor-positive, HER2-negative (HR+/HER2-) subtypes, show poorer prognosis. CDK4/6 inhibitors, combined endocrine therapy (ET) have become the standard for HR+/HER2- metastatic cancer, yet younger are underrepresented...
Objectives: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality. Despite curative surgery, recurrence common in Stage I NSCLC, highlighting the need for improved prognostic classification. This study aims to evaluate key pathological factors affecting and survival investigate potential benefit adjuvant chemotherapy (ACT) patients with NSCLC. Methods: A retrospective analysis was conducted on NSCLC who underwent surgery between 2010 2024. Demographic...
Background and Objectives: CDK4/6 inhibitors (CDK4/6i) have revolutionized the treatment of hormone receptor-positive HER2 negative (HR(+)/HER2(-)) breast cancer. Despite their efficacy, interstitial lung disease (ILD) remains a rare but potentially fatal adverse effect. This study aims to evaluate incidence clinical characteristics ILD associated with in cancer patients Turkey. Materials Methods: A retrospective multicenter analysis included 464 treated between January 2017 April 2024....
Background and Objectives: KRAS genes are among the most prominent oncogenes that trigger tumor formation in colorectal cancer (CRC) serve as predictive biomarkers for resistance to anti-EGFR therapies metastatic (mCRC) patients. However, prevalence mutation spectrum of gene family mCRC patients Turkey have not been sufficiently analyzed. This study investigates frequency distribution mutations across different regions examines gender-related variations. Materials Methods: multicenter...
Background: This study aimed to compare the clinical, pathological, and biochemical characteristics of upper rectal cancer (URC) mid–lower (MLRC) in stage II III non-metastatic identify distinct prognostic factors influencing survival recurrence. Material Methods: retrospective cohort included 100 patients with adenocarcinoma who underwent neoadjuvant chemoradiotherapy (nCRT) followed by curative-intent surgery between 2021 2024. Patients were categorized into URC (n = 53) MLRC 47) groups....
Abstract Background Tumor-infiltrating lymphocytes (TILs) have emerged as predictive biomarkers in HER2-positive breast cancer, correlating with treatment response and survival outcomes. This study evaluates the impact of TIL levels Ki67 suppression on neoadjuvant therapy efficacy this patient population. Materials methods A retrospective analysis 136 cancer patients was conducted. Patients were stratified by levels, clinical outcomes, including expression, pathological complete (pCR),...
Neoadjuvant chemotherapy (NAC) is extensively employed in breast cancer (BC), primarily for aggressive subtypes like triple-negative and human epidermal growth factor receptor 2 (HER2)-positive BC estrogen receptor-positive (ER+)/HER2- with high-risk features. In ER+/HER2- BC, pathological complete rates are much lower (<10%), while axillary dissection higher. This study focuses on hormone (HR+)/HER2- patients undergoing NAC, examining its impact response (pCR) rates, specific attention...
Background and Objectives: Colorectal cancer (CRC) poses a major global health challenge, with high incidence rates ongoing treatment debates. Adjuvant chemotherapy benefits for high-risk subgroups, particularly stage II disease, remain controversial. This study seeks to clarify this issue by specifically examining the impact of adjuvant on disease-free survival (DFS) overall (OS) in patients diagnosed T4 colon cancer. Materials Methods: retrospective analyzed undergoing radical surgery...
Background and Objectives: This investigation aimed to determine the impacts of concurrent proton pump inhibitors (PPIs) on progression-free survival (PFS) in patients with hormone receptor-positive HER2-negative metastatic breast cancer managed palbociclib or ribociclib as either initial subsequent line therapy option. Materials Methods: In this retrospective study, were classified "concurrent PPIs" if PPIs given for at least two-thirds period, "no no during period therapy. Each patient was...
Pulmonary large cell neuroendocrine carcinoma (PLCNEC) is a rare but aggressive subtype of lung cancer with an incidence approximately 3 %. Identifying effective prognostic indicators crucial for guiding treatments. This study examined the relationship between inflammatory markers and PLCNEC patient overall survival (OS) sought to determine their significance in PLCNEC.
Breast cancer (BC) and lung are the most frequently reported cancers in women men, respectively, terms of both numbers cases deaths. 1 It is estimated that 6%-10% BC present as de novo metastatic at time diagnosis, between 25% 30% experience recurrence. 2 While no definitive cure for breast (MBC) available to date, advent novel systemic therapies has enhanced survival outcomes patients with this condition.
We investigated the diagnostic value of bone marrow (BM) sampling in investigation HIV-infected patients presenting to a major London HIV treatment centre between 1999 and 2004. One hundred fourteen consecutive underwent 130 BM samplings. The majority aspirates were normal or showed non-diagnostic changes; microscopy revealed lymphoma one mycobacterial infection two. Subsequent culture identified nine samples. trephine had yield 26% with fever cytopaenia (including mycobacteriosis 14%, 6%,...
Purpose We aimed to determine the COVID-19 infection rate and factors that affect hospitalization prognosis in patients receiving systemic chemotherapy (CT), immunotherapy (IT) molecular-targeted therapies at our hospital within three months after onset of pandemic. Materials methods The who received treatment unit with diagnosis cancer between 11 March 2020 June were included. clinical demographic characteristics patients, treatments they (CT, IT, targeted therapies), stage disease...
Lasers have been used in the management of benign prostatic hyperplasia for last two decades. To be comparable, they should reduce or avoid immediate and long-term complications transurethral resection prostate (TURP) open prostatectomy (OP), especially bleeding need blood transfusion. Although Holmium laser treatment was compared frequently terms cardiovascular safety with TURP OP, photoselective vaporisation (PVP) not largely evaluated. In this article we analyzed current literature to see...
Primary epiploic appendagitis (PEA) is self limiting inflammatory disease of colonic appendices. Herein, a 40 years old patient describing abdomino-inguinal pain with clotty hematuria having PEA was presented. At first, the thought to have primary bladder pathology, but after meticioulus examination, he found and managed by conservative measures. Although does not require surgical intervention, it may mimic other acute abdominal disorders which can be difficult differentiate. Appendices...
Renal stone disease is characterized by the differences depending on age, gender, and geographic location of patients. Seventy-five percent renal components calcium (Ca). The most common type stones Ca oxalate stones, while phosphate, uric acid, struvite, sistine are more rarely reported. Other than these types, triamterene, adenosine, silica, indinavir, ephedrine also reported in literature as case reports. However, to best our knowledge, aluminum hydroxide was not before. Herein we will...
BACKGROUND: Melanoma is the most lethal variant of skin cancer. In United States, it ranks as fifth common Due to aggressive course melanoma, crucial predict its prognosis. clinical practice, a range accessible and low-cost parameters are investigated. This study aims evaluate relationship between hemoglobin/red blood distribution width (HRR) at time diagnosis overall survival (OS), well potential therapeutic prognostic markers, by analyzing patients diagnosed with melanoma.METHODS: Patients...