A5075032325- Gastric Cancer Management and Outcomes
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Fibroblast Growth Factor Research
- Intraperitoneal and Appendiceal Malignancies
- Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Metastasis and carcinoma case studies
- Immunotherapy and Immune Responses
- Genetic factors in colorectal cancer
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lymphoma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
Memorial Ankara Hospital
2020-2025
Ankara Bilkent City Hospital
2023-2025
Sağlık Bilimleri Üniversitesi
2017-2024
City Hospital
2020-2024
Weatherford College
2020-2024
Ankara Yıldırım Beyazıt University
2020-2024
Software (Germany)
2024
Creative Commons
2023
Batman University
2021
Ministry of Health
2021
To evaluate the immunogenicity and safety of CoronaVac vaccine in patients with cancer receiving active systemic therapy.
Despite the extensive research on hepatocellular carcinoma (HCC) exploring various treatment strategies, survival outcomes have remained unsatisfactory. The aim of this was to evaluate ability machine learning (ML) methods in predicting probability HCC patients. study retrospectively analyzed cases patients with stage 1-4 HCC. Demographic, clinical, pathological, and laboratory data served as input variables. researchers employed feature selection techniques identify key predictors patient...
In this Turkish Oncology Group study, we aimed to evaluate the effectiveness of trastuzumab emtansine (TDM1) in adjuvant treatment early-stage human epidermal growth factor receptor-2 (HER2)-positive breast cancer with residual disease using real-life data. A total 13 centers participated study between September 2019 and October 2024. Patients HER2-positive who underwent surgery after completing neoadjuvant chemotherapy HER2-targeted therapies had invasive or axillary lymph nodes received...
Background and Objectives: Conversion surgery for liver metastatic colorectal cancer (mCRC) has been associated with prolonged survival. This study aimed to evaluate the efficacy safety of integrating biological therapies fluorouracil-based induction chemotherapy in patients isolated mCRC who subsequently underwent curative resection both primary tumor metastases. Materials Methods: multicenter, retrospective study, conducted by Turkish Oncology Group (TOG), included 116 from 11 tertiary...
Abstract Background The optimal treatment for metastatic colorectal cancer (mCRC) after the second line is still controversial. Regorafenib has been standard of care in this setting as it improved overall survival (OS) compared to placebo. In real-world practice chemotherapy rechallenge also a preferred option even though supporting evidence not enough. We aim compare efficacy regorafenib and 5-fluorouracil-based (5-FU) third mCRC. Methods retrospective multi-institutional trial, mCRC...
In recent years, machine learning (ML) methods have gained significant popularity among medical researchers interested in cancer. We aimed to test different models predict both overall survival and at specific time points patients with non-metastatic colorectal cancer (CRC). The clinicopathological treatment data of CRC more than 10 years follow-up a single center were retrospectively reviewed. 1, 2, 3, 5, 10-year rates for all stages I-III statistically calculated using the Kaplan-Meier...
Colorectal cancer (CRC) is the third most common in world and second leading cause of cancer-related deaths. Several mutations are involved development CRC. The prognostic significance KRAS mutation has been discussed many studies. We aimed to investigate number metastatic CRC (mCRC).Patients with gene were included study. They divided into 2 groups as single multiple gene.For study, 425 patients screened. was positive 191 (45%). One hundred ninety-one 171 (90%) had 20 (10%) mutations....
We aimed to determine whether serum SPON2 is a useful biomarker in the detection of Diabetic Nephropathy (DN) and compare levels with 24-hour urinary albumin excretion rate (UAER) patients DN at different stages.The cohort included 80 adult T2D 20 healthy controls. The were divided into four groups according UAER creatinine (sCr) levels. Group 1 consisted normoalbuminuria (n = 20), 2 microalbuminuria 3 macroalbuminuria 20) 4 albuminuria sCr > 1.5 mg/dL 20).There no significant differences...
This study examined the difference in overall survival (OS) between peritoneal metastatic gastric cancer (PMGC) patients who underwent neoadjuvant chemotherapy followed by cytoreductive surgery ± hyperthermic intraperitoneal (CRS HIPEC) and those did not have but instead received palliative chemotherapy.This retrospective included 80 were up with diagnosis of PMGC, undergoing CRS HIPEC group) receiving only (non-surgical group), medical oncology clinic April 2011 December 2021....
Various psychiatric disorders, especially depression and anxiety, are seen in 2/3 of the chronic rheumatic diseases with pain. In this study, we aimed to define anxiety rates Rheumatoid Arthritis (RA) Ankylosing Spondylitis (AS) patients (under treatment) similar age gender; compare obtained data each other healthy control group; also investigate relationship between human leukocyte antigen B27(HLA-B27) AS, Factor (RF) anti-cyclic citrullinated peptide antibodies (anti-CCP) RA depression.46...
Gallstone disease (GD) is a common gastrointestinal disease. Although traditional diagnostic techniques, such as ultrasonography, CT, and MRI, detect gallstones, they have some limitations, including high cost potential inaccuracies in certain populations. This study proposes machine learning-based prediction model for gallstone using bioimpedance laboratory data. A dataset of 319 samples, comprising161 patients 158 healthy controls, was curated. The comprised 38 attributes the participants,...
The prognostic role of fibroblast growth factor 11 (FGF11) has only been reported in cancers such as nasopharyngeal carcinoma and prostate cancer. FGF11 breast cancer is not fully known. It was aimed to compare expression levels de novo metastatic hormone receptor-positive, human epidermal reseptor-2-negative tumor tissue healthy investigate the effect on survival patients. To determine rate, patients diagnosed by biopsy individuals who underwent due benign lesions were used. study...
Introduction: Locoregional gastric cancer is a still serious problem and perioperative treatments may improve the success of management. Different regimens were examined. The present study purposed to compare efficacy fluorouracil-leucovorin-oxaliplatin-docetaxel (FLOT) docetaxel-cisplatin-fluorouracil (DCF) regimens. Methods: A retrospective multicenter assessed patients with locoregional cancer. There are 240 (137 DCF, 103 FLOT). Survival rates compared. Results: Demographic features...
Introduction Pembrolizumab is a humanized monoclonal antibody IgG4 programmed cell death protein 1 antagonist, and its use in oncology has been increasing recent years, providing durable favorable responses tolerable toxicity profiles various types of cancer. We describe case pembrolizumab related perforated appendicitis patient with stage 3C malignant melanoma (MM). Case report A 70-year-old male who had no known disease was diagnosed MM as result the excision mass on his right shoulder....
Introduction Treatment options for metastatic renal cell carcinoma disease have been improved in recent years. However, there is still no optimal treatment sequence or combination disease. We aimed to investigate whether patients differed terms of outcomes regarding pre-nivolumab tyrosine kinase inhibitors (TKIs). Material and methods The analysis was performed after all cohorts were sub-grouped into two groups according TKIs as following the sunitinib arm pazopanib arm. Result A total 75...
Aim The aim of this study was to investigate the relationship between health literacy (HL) and quality life (QoL) in type 1 diabetes mellitus (DM) patients. Method This conducted February 2020 May at University Health Sciences Bursa Yuksek Ihtisas Training Research Hospital, Turkey. A total 155 patients with DM ages 18-65 were included study. QoL evaluated Audit Diabetes Dependent questionnaire HL Newest Vital Sign (NVS) obtained results compared. Results weighted impact score for overall...
The emergence of COVID-19 pandemic caused a global public health problem.In this article, anxiety and insomnia rates cancer patients who received chemotherapy during outbreak period were determined.In addition, patients' information opinions about discussed.The study included 218 apply to outpatient clinic between May-June 2020, aged 18 over, receiving chemotherapy.Generalized Anxiety Disorder Insomnia Severity Index questionnaire forms given fill the evaluate their levels.We also prepared...
Introduction: Fluoropyrimidine and platinum-based chemotherapy regimens are widely accepted for metastatic gastric cancer (GC). Because of drug toxicity, a combined two-drug cytotoxic regimen is recommended first-line therapy, while three-drug patients with medically fit better performance status. In this study, it was aimed to compare modified FOLFOX-6 (mFOLFOX-6) DCF (mDCF) in terms survival side effects treatment GC. Methods: We retrospectively reviewed the clinical record or...
The relationship of the ABO blood group system with immune response is known, but its checkpoint inhibitors (ICIs) has not been clearly investigated until now.In this study, between different groups and nivolumab treatment in patients advanced malignant melanoma was investigated.The data who used for April 2018 2021 were retrospectively reviewed.A total 73 included study. In progression-free survival (PFS) analysis according to groups, it 3.9 months, 16.1 20.0 months 3.0 A, B, AB O,...
In our study, we aimed to evaluate the pathological response rates and side effect profile of adding pertuzumab treatment HER2+ locally advanced, inflammatory, or early-stage breast cancer. This study was conducted by Turkish Oncology Group (TOG) with data collected from 32 centers. Our multicentric, a total 364 patients were included. The median age 49 years (18-85 years). Two hundred fifteen (60%) cases hormone receptor/HER2+ positive(ER+ PR+, both), 149 (40%) them HER2-rich (ER PR...
Purpose: To evaluate the clinicopathological characteristics and surgical outcomes in patients with pure ovarian immature teratomas (POITs). Materials Methods: In this multicenter study, a retrospective review was made of databases six Gynecology Oncology Departments Turkey to identify POITs who had undergone surgery between 1993 2019. Results: Evaluation 48 median age at diagnosis 22.5 years (range, 15-37 years). 40 (83%) patients, stage I determined eight an advanced (IIIB, IIIC, IVB)...
Hepatotoxicity is observed due to cyclin-dependent kinase (CDK4/6) inhibitors used treat hormone receptor-positive metastatic breast cancer. However, it should not be ignored that denosumab may hepatotoxic, although rare.A 73-year-old female patient with cancer axillary lymph node, adrenal gland and bone metastases was started on ribociclib letrozole treatment. Ribociclib treatment discontinued grade 4 hepatotoxicity during treatment, but liver function tests did decrease. After...
Objective Combination therapies such as FOLFIRINOX or gemcitabine-nanoparticle albumin-bound paclitaxel (GnP) are recommended for the first-line treatment of patients with advanced pancreatic cancer. The purpose this study was to evaluate efficacy gemcitabine-based second-line in whose disease progressed on FOLFIRINOX. Method Patients diagnosed cancer 7 tertiary hospitals Turkey were included. divided into 3 different groups according their regimens: GnP, gemcitabine doublet...