A5061860445- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Cutaneous Melanoma Detection and Management
- Ocular Diseases and Behçet’s Syndrome
- Cancer Treatment and Pharmacology
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Immunotherapy and Biomarkers
- Cardiac, Anesthesia and Surgical Outcomes
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Melanoma and MAPK Pathways
- Cancer survivorship and care
- Viral-associated cancers and disorders
- Rheumatoid Arthritis Research and Therapies
- Clinical practice guidelines implementation
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Platelet Disorders and Treatments
- Lung Cancer Research Studies
- Thyroid Cancer Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- Hematological disorders and diagnostics
- Sarcoma Diagnosis and Treatment
Wittenberg University
2025
Erciyes University
2024-2025
Martin Luther University Halle-Wittenberg
2025
Hacettepe University
2012-2024
BioNTech (Germany)
2023
Bezmiâlem Vakıf Üniversitesi
2020-2022
Hacettepe University Hospital
2004-2021
Charles River Laboratories (Netherlands)
2021
John Wiley & Sons (United States)
2021
Hudson Institute
2021
BackgroundTumor human papillomavirus (HPV) status is an important prognostic factor in locoregionally advanced squamous cell carcinoma of the head and neck (SCCHN). Prognostic value recurrent and/or metastatic (R/M) disease remains to be confirmed. This retrospective analysis EXTREME trial, comparing chemotherapy plus cetuximab with first line R/M SCCHN, investigated efficacy prognosis according tumor p16 HPV status.Patients methodsPaired tissue samples were used: p16INK4A expression was...
4000 Background: Efficacy analyses of the randomized phase II OPUS trial have previously failed to show significant improvements in progression-free survival time (PFS) or overall response, although a significantly higher response rate was achieved patients with good performance status (ECOG 0/1) and curative surgery for cetuximab added FOLFOX versus alone first-line treatment mCRC observed. KRAS mutation has been related efficacy anti-epidermal growth factor receptor (anti-EGFR) targeted...
Recent studies point out a probable role of streptococcal antigens in the pathogenesis Behçet's disease (BD). This has led to proposal benzathine penicillin as therapeutic modality BD.A prospective study was conducted compare efficacy colchicine and + treatments on mucocutaneous manifestations BD.60 patients (group I) were given alone 94 II) penicillin. Frequency, number, duration severity oral aphthous ulcers, genital ulcers erythema nodosum determined before after treatment.In group I, all...
8007 Background: The multinational, randomized, phase III FLEX study compared cisplatin/vinorelbine (CT) plus the EGFR- antibody, cetuximab (Erbitux), with CT alone in 1st-line treatment of patients (pts) advanced EGFR-expressing NSCLC and demonstrated a statistically significant OS benefit for combination. We hypothesized that KRAS mutation status is predictive efficacy enables optimal use cetuximab. relationship between early-onset acne-like rash (ie developed ≤21 days initiation) time pts...
Abstract Objective . Because exposure to streptococcal antigens might be a major disease activity—provoking factor in Behçet's disease, this study was undertaken evaluate the effectiveness of benzathine penicillin prophylaxis recurrent arthritis episodes during course disease. Methods A prospective, randomized design used allocate patients receive colchicine alone or plus for 24 months. Results The duration, severity, and pattern were found similar 2 treatment groups, but number...
1. In this study, embryotoxicity and effects of in ovo administration aflatoxin B1 (AFB1) on the embryonic development bursa Fabricius were determined fertilised chicken eggs by histological methods histochemical demonstration acid phosphatase (ACP-ase) enzyme. Peripheral blood lymphocyte percentages also estimated. 2. Embryonic stages according to Hamburger-Hamilton (H-H) scale. Mortality rates increased AFB1-injected groups a dose-dependent manner. deaths concentrated at H-H 31 5 ng...
To evaluate the immunogenicity and safety of CoronaVac vaccine in patients with cancer receiving active systemic therapy.
This study was planned to explore the alterations of endothelial functions in prethrombotic state Behçet's disease (BD) patients.Plasma levels secretory markers, vivo molecular haemostatic and fibrinolytic parameters were cross-sectionally determined group.In our tertiary referral centre, 30 (13 men, 17 women) BD patients, mean age 31 +/- 7 years, 15 (eight seven healthy volunteers, 26 9 eligible for inclusion after obtaining their written consents.All plasma samples assays obtained before...
Background Resistance to antiemetic treatment with 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists is still a major problem resulting in patient discomfort and poor compliance chemotherapy. We hypothesized that clinical resistance 5-HT3 associated the single-nucleotide polymorphism (3435C > T) gene codes for drug efflux transporter adenosine triphosphate–binding cassette subfamily B member 1 (ABCB1). Methods Patients cancer (N = 216) treated chemotherapeutic regimens composed of...
1. Protective action of an enzyme-linked polyvinylpolypyrrolidone (PVPP, Mycofix Plus) against the immunosuppressive effect afatoxins (AF) was evaluated by determination peripheral blood T-lymphocyte proportions and splenic plasma cell counts. Histological changes in lymphoid organs were also investigated light microscopy. One-d-old broiler chicks (Hybro) received 2.5 mg/kg diet AF (83.06% AFB1, 12.98% AFB2, 2.84% AFG1, 1.12% AFG2) with or without PVPP (3g/kg diet) until 21 d age. When...
3511 Background: Addition of cetuximab (cet) to first-line chemotherapy (CT) was shown significantly improve clinical benefit in patients (pts) with KRAS wild-type (wt) mCRC. Pts codon 12 or 13 mutations are excluded from cet treatment. Studies suggest that not all equivalent their biological effects. We investigated the influence mutation G13D on outcome compared pts other tumor wt tumors a pooled analysis CRYSTAL and OPUS studies. Methods: Variation treatment effect by status, status...
Çelik I, Akalin S, Erbaş T. Serum levels of interleukin 6 and tumor necrosis factor-α in hyperthyroid patients before after propylthiouracil treatment. Eur J Endocrinol 1995;132:668–72. ISSN 0804–4643 Contrary to the usual inhibitory role (TNF-α) thyroid metabolism, it also has specific stimulatory effects autoimmune disorders, including induction HLA class II antigen-presenting cell—T cell interaction. Despite high intrathyroidal concentrations, various studies were not able demonstrate...
The aim of this study was to evaluate the time union and complications in cases tibial diaphysis distal fractures fixed with a minimally invasive percutaneous plate.Thirty-five patients (23 males, 12 females) were operated on using plate osteosynthesis (MIPPO) principles for fractures. Twenty-eight closed seven open After direct or indirect fracture reduction, advanced through submuscular extraperiosteal tunnel incision without opening line. screws proximal incisions. Clinical radiological...
New thalidomide analogs have been designed and synthesized by hybridizing the immunomodulatory gutarimide moiety with three antiproliferative nuclei: quinazolinedione, phthalazinedione, quinoxalinone. The biological results revealed strong impact of quinazoline derivatives 7a 28, phthalazine based 20a against HepG-2, MCF-7, PC3, HCT-116 cell lines, compared to thalidomide. In particular, compound was most promising as it had far better activity than regard inhibition TNF-α, IL-6, caspase 3,...
Proteolysis targeting chimeras (PROTACs) have proven to be a novel approach for the degradation of disease-causing proteins in drug discovery. One E3 ligases which efficient PROTACs been described is Von-Hippel-Lindau factor (VHL). However, development has so far often relied on minimum computational tools, that it mostly based trial-and-error process. Therefore, there great need resource- and time-efficient structure-based or approaches streamline PROTAC design. In this study, we present...