A5024593913- Scheduling and Timetabling Solutions
- Lung Cancer Treatments and Mutations
- Vehicle Routing Optimization Methods
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Constraint Satisfaction and Optimization
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Healthcare Operations and Scheduling Optimization
- Gastric Cancer Management and Outcomes
- Sulfur Compounds in Biology
- Radiomics and Machine Learning in Medical Imaging
- Glutathione Transferases and Polymorphisms
- Multiple Myeloma Research and Treatments
- Metastasis and carcinoma case studies
- Operations Management Techniques
Memorial Ankara Hospital
2023-2025
Ankara Bilkent City Hospital
2023-2025
Ankara Yıldırım Beyazıt University
2016-2025
Konya Eğitim ve Araştırma Hastanesi
2023
City Hospital
2023
Ankara Atatürk Göğüs Hastalıkları Ve Göğüs Cerrahisi Eğitim Ve Araştırma Hastanesi
2019-2022
Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi
2022
Ankara Spine Center
2020-2021
Hacettepe University
2012-2020
Izmir Institute of Technology
2020
Meta-heuristics such as simulated annealing, genetic algorithms and tabu search have been successfully applied to many difficult optimization problems for which no satisfactory problem specific solution exists. However, expertise is required adopt
Background: Although higher-generation TKIs are associated with improved progression-free survival in advanced NSCLC patients EGFR mutations, the optimal selection of TKI treatment remains uncertain. To address this gap, we developed a web application powered by reinforcement learning (RL) algorithm to assist guiding initial decisions. Methods: Clinical and mutational data from were retrospectively collected 14 medical centers. Only complete sufficient follow-up included. Multiple supervised...
Background and Objectives: Despite advances in surgery perioperative chemotherapy, locally advanced gastric cancer continues to pose significant challenges, creating a pressing need for biomarkers capable of predicting therapeutic efficacy survival outcomes. This study evaluates the prognostic predictive significance large unstained cells (LUCs), morphologically distinct subset white blood identified peripheral that remain by standard hematological dyes, as potential indicators immune...
Purpose: CDK4/6 inhibitors require meticulous monitoring due to their potential cause hematological toxicities and hepatotoxicity. This study evaluates the safety of combining with palliative radiotherapy in patients metastatic hormone receptor-positive HER2-negative breast cancer. Patients Methods: included 188 treated between January 2021 June 2024. Data on patient demographics, tumor characteristics, treatment interventions were extracted from medical records. The primary focus was...
Ribociclib, palbociclib and abemaciclib are currently approved CDK4/6 inhibitors along with aromatase as the first-line standard-of-care for patients hormone receptor-positive, HER2-negative metastatic breast cancer.
Introduction and aim To investigate the effect of prognostic nutritional index on treatment response survival in patients with metastatic renal cell cancer. Methods We retrospectively analyzed modalities; demographic, clinical pathological features 396 RCC index. Based median value, were grouped as having low high values. Kaplan-Meier method was used for analysis, Cox-regression analysis multivariate analysis. Results The overall 39 months (95% CI 26.1–51.8), 28 17.9–38) 7 4.7–9.2)...
Clear cell renal carcinoma (ccRCC) is the most common malignancy. Hypoxia-inducible factors, HIF-1α and HIF-2α, are expressed in majority of ccRCC. Targeting immune checkpoints with blockade PD-1 its ligand PD-L1 reorganizes T-cell activity tumor microenvironment provides important antitumor responses. upregulation has been found to be hypoxia-inducible factor (HIF) dependent. Our aim demonstrate association between HIF expression reveal role prognosis microenvironment.Surgical specimens...
Introduction Targeted therapy is the main treatment option for oncogene-addicted non-small cell lung cancer (NSCLC). It known that inflammation can affect survival. Therefore, we aimed to evaluate effect of host on survival and outcome by using derived neutrophil-lymphocyte ratio (dNLR) systemic immune-inflammation index (SII). Material methods The advanced epidermal growth factor receptor mutant NSCLC patients diagnosed between 2014 2019 were included. SII dNLR calculated from pretreatment...
This study aims to report the efficacy and safety of capecitabine plus temozolomide (CAPTEM) across different lines treatment in patients with metastatic neuroendocrine tumors (NETs).
Colorectal cancer (CRC) is one of the most common cancers worldwide and survival still approximately 24 months. Recently, importance molecular features, tumor localization, also inflammatory status increased, these entities can be used as a predictive marker for colon tumor. However, since tests are expensive unachievable, there need new prognostic markers that easily inexpensive.We aimed to investigate effect red cell distribution width (RDW)-to-platelet ratio (RPR) which reflects...
Background To describe the prognostic value of neutrophil–lymphocyte ratio and its effect on survival in patients with advanced renal cell carcinoma. Methods We retrospectively analyzed 331 patients. The cut-off was specified as “3” which is mostly close—and also clinically easily applicable—to median level our study group. High group identified >3 (n = 160) low ≤3 163). Results A total (with 211 male 120 female) were enrolled to study. age 58. International Metastatic RCC Database...
Inflammation and nutrition are important parameters that significantly affect survival in various malignancies. Prognostic nutritional index (PNI) modified Glasgow prognostic score (mGPS) can reflect both inflammatory conditions. Therefore, we aimed to evaluate the value of PNI mGPS patients who had targetable mutation also received targeted therapy.