A5075291709- Cancer Diagnosis and Treatment
- Pharmaceutical studies and practices
- Pharmaceutical Economics and Policy
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Chronic Lymphocytic Leukemia Research
- Chemotherapy-related skin toxicity
- Health Systems, Economic Evaluations, Quality of Life
- Cancer survivorship and care
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Palliative Care and End-of-Life Issues
- Prostate Cancer Treatment and Research
- Gastric Cancer Management and Outcomes
- Head and Neck Cancer Studies
- Pharmaceutical Practices and Patient Outcomes
- Nausea and vomiting management
- Patient-Provider Communication in Healthcare
- Vitamin D Research Studies
- Healthcare Education and Workforce Issues
- COVID-19 and healthcare impacts
- Respiratory and Cough-Related Research
- Cancer-related Molecular Pathways
- Anesthesia and Pain Management
Muğla University
2019-2025
Primary HealthCare
2024
Primary Health Care
2024
State Hospital
2024
Ankara University
2014-2024
Ministry of Health
2014-2023
Hacettepe University
2009-2017
Zeynep Kamil Hospital
2005
Drug shortages have been identified as a public health problem in an increasing number of countries. This can negatively impact on the quality and efficiency patient care, well contribute to increases cost treatment workload care providers. Shortages also raise ethical political issues. The scientific evidence drug is still scarce, but many lessons be drawn from cross-country analyses. objective this study was characterize, compare, evaluate current systemic measures legislative...
There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor (CDK4/6) based therapy. We aimed to evaluate which oncologists prefer patients with disease progression under CDKi. In addition, we show the effectiveness of systemic treatments CDKi and whether there a survival difference between hormonal (monotherapy vs. mTOR-based).A total 609 from 53 centers were included study....
Management of melanoma has changed significantly with the discovery targeted therapies and immune checkpoint inhibitors (ICI). Our aim in study is to determine which treatment alternatives, specifically dabrafenib plus trametinib ICIs, are effective adjuvant therapy as first-line metastatic therapy. This retrospective, multicenter included 120 patients diagnosed stage IIIB-IIID receiving both between 2007 2023. Data on clinicopathologic characteristics, regimens outcomes were collected....
Background This study explores Turkish medical oncologists' perceptions of integrating international treatment guidelines with national reimbursement policies, considering local legal, economic, and healthcare constraints.
Introduction: Although different risk factors for oxaliplatin-associated chronic peripheral neuropathy have been identified and the predictive value of neuroinflammatory cytokines has often emphasized, a clearly accepted biomarker with economical, reproducible, easily accessible properties not yet identified. In this study, we aimed to determine relationship between serum uric level measured at time diagnosis oxaliplatin-related neuropathy, based on literature information diabetic acid...
Introduction: Regulatory agency comparisons can be of more value and facilitate improvements if conducted among countries with common challenges similar health characteristics. A study was to compare the registration review model used by Turkish Medicines Medical Devices Agency (Türkiye Ilaç ve Tibbi Cihaz Kurumu; TITCK) those four similar-sized regulatory agencies identify areas strength requiring further improvement within TITCK in relation process as well assess level adherence good...
Ribociclib, palbociclib and abemaciclib are currently approved CDK4/6 inhibitors along with aromatase as the first-line standard-of-care for patients hormone receptor-positive, HER2-negative metastatic breast cancer.
The only phase 3 study on the effectiveness of CDK 4-6 inhibitors in first-line treatment premenopausal patients with hormone receptor (HR) positive, HER2 negative metastatic breast cancer is MONALEESA-7 study, and data palbociclib limited. Data are also limited regarding whose dose was reduced due to neutropenia, most common side effect inhibitors. In our we aimed evaluate ribociclib reduction neutropenia progression-free survival. Our a multicenter, retrospective factors affecting survival...
Background: Infection with the Hepatitis C Virus (HCV) is a widespread transmittable disease diagnosed prevalence of 2.0%. Fortunately, it now curable in most patients. Sales medicines to treat HCV infection grew 2.7% per year between 2004 and 2011, enhanced by launch protease inhibitors (PIs) boceprevir (BCV) telaprevir (TVR) addition ribavirin pegylated interferon (pegIFN). Costs will continue rise new treatments including sofosbuvir, which include free regimens. Objective: Assess uptake...
Controlled hypotension is a reversible procedure in which the patient's baseline mean arterial blood pressure reduced by 30% and sustained at 60–70 mmHg during procedure. It decreases loss provides clear surgical field procedures. The purpose of this study was to compare efficacy controlled agents esmolol, remifentanil, nitroglycerin functional endoscopic sinus surgery, terms hemodynamic changes impact on efficiency. research carried out as cohort study. Patients who underwent surgery were...
Social media disorder (SMD) is defined as a behavioral addiction and has been associated with depression, loneliness, narcissism, low self-esteem, poor sleep quality, academic performance. Ostracism term being ignored or excluded by others. The purpose of this study to evaluate the predictors ostracism in adolescents test effect SMD on ostracism.This was performed survey study. Adolescents between 14 18 years age were administered structured questionnaire assess socio demographic properties,...
Trastuzumab emtansine is an antibody–drug conjugate that effective in human epidermal growth factor receptor-2 expressing advanced breast cancer. generally well tolerated and grade 3–4 toxicities are rare. Pulmonary complications were rarely reported. Here we present a patient presenting with dyspnea after trastuzumab therapy treated diagnosis of interstitial pneumonitis.
Hypersensitivity reactions, cumulative fluid retention, and neurotoxicity are frequently seen toxicities related to docetaxel. Fluid retention may be present as edema, weight gain, or third place collection. Pericardial effusion is rarely with docetaxel treatment. We report a 58-year-old female patient who was presented pericardial tamponade after three cycles of therapy.
Introduction: This study aimed to show the relationship between serum uric acid level measured at diagnosis and BRAF mutation status in primary tumor tissue patients with metastatic colorectal cancer. Methods: In this retrospective cross-sectional study, 264 (64% male) whose was time of determined were included. Results: The rate 14% (n = 37). median levels all 6.9 mg/dL (25%, 75% percentile range 3.7, 8.2). cut-off value 6.6 mg/dL. Sensitivity specificity for mutated 84% 27%, respectively....