A5090234989- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Families in Therapy and Culture
- Lung Cancer Research Studies
- Chemotherapy-related skin toxicity
- Chronic Lymphocytic Leukemia Research
- Islamic Studies and History
- Lymphoma Diagnosis and Treatment
- Islamic Thought and Society Studies
- Glycosylation and Glycoproteins Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Melanoma and MAPK Pathways
- Gastric Cancer Management and Outcomes
- Liver physiology and pathology
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Renal cell carcinoma treatment
- Acute Myeloid Leukemia Research
- Biosimilars and Bioanalytical Methods
- Cancer Diagnosis and Treatment
Cukurova University
2012-2025
Istanbul Şehir University
2019
Management of melanoma has changed significantly with the discovery targeted therapies and immune checkpoint inhibitors (ICI). Our aim in study is to determine which treatment alternatives, specifically dabrafenib plus trametinib ICIs, are effective adjuvant therapy as first-line metastatic therapy. This retrospective, multicenter included 120 patients diagnosed stage IIIB-IIID receiving both between 2007 2023. Data on clinicopathologic characteristics, regimens outcomes were collected....
Background Trastuzumab is a recombinant humanized monoclonal antibody used to treat human epidermal growth factor receptor 2 positive breast cancer, with recognized associated cardiotoxicity. In this retrospective observational study, we investigated cardiotoxicity on clinical outcomes using trastuzumab in women referred our clinic. Materials and methods The study was made up of 111 2-overexpressing cancer who received the Medical Oncology Department, between 2010 2013. Results A > 10%...
Among patients with haematologic disorders, mucormycosis most commonly occurs in those acute leukaemia or lymphoma who have developed neutropenia due to malignancy chemotherapy, and transplanted receiving immunosuppressive treatment. Here, we aim present a retrospective study conducted over 5-year period (2001-2005). The included 20 malignancies proven admitted Medical Oncology Divisions Cukurova University Hospital. frequent sites of infection were paranasal sinuses (95%) lung (5%)....
Background: The aim of this study was to investigate the general characteristics patients with deep vein thrombosis (DVT) and pancreatic cancer as well evaluate relationship between mean platelet volume (MPV), DVT survival. Materials Methods: Seventy-seven cancer, who were admitted Cukurova University Medical Faculty, Department Oncology, enrolled in Results: age <TEX>$59{\pm}20$</TEX>. Forty-nine (63.6%) men 28 women (36.4%). Sixty-eight (88.3%) had adenocarcinoma 9 (11.7%) a malignant...
We present a case of granulocytic sarcoma (GS) the heart. A 28-year-old man with relapsed acute myelogenous leukemia (AML-M2) had undergone non-myeloablative allogeneic peripheral stem cell transplantation. Three years following transplantation, masses were evidenced in his heart by echocardiography but completely disappeared common chemotherapy etoposide, mitoxantrone, ara-C (EMA) regimen for AML. The involvement GS is very rare and this first extramedullary disease after Here we history...
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe bone disease for which pathogenetic mechanisms and risk factors are not fully understood. The present study evaluated data 652 patients with metastasis that had undergone treatment biphosphonates. Subsequently, 24 BRONJ 20 control without were treated zoledronic acid enrolled. It was found occurred in 3.6% patients. mean age administration dental to be significantly associated development (P=0.049 P=0.013, respectively)....
This study aimed to present the clinicopathological characteristics and treatment of patients with bladder carcinoma sarcomatoid differentiation at our institution.Between 1995- 2009, 950 were followed-up for carcinoma. Among them, 14 retrospectively reviewed, their clinical, pathological features recorded.Median age was 65 years (range: 41-86 years), 12 (86%) being male 2 (14%) female. All presented hematuria 11 (88%) had a history smoking. The tumor growth pattern solid in 10 patients,...
Objectives Regorafenib improved overall survival in patients with metastatic colorectal cancer (mCRC) refractory to standard therapies two randomised, phase III trials, but has not been evaluated Turkey. REGARD the safety and efficacy of regorafenib Turkish treatment-refractory mCRC. Design Open-label, single-arm, IIIb study conducted between July 2013 April 2015. Setting 11 tertiary centres Participants Eligible were adults mCRC who had disease progression within 3 months after receiving...
AimTo evaluate the inhibitory effects of ornidazole on proliferation and migration metastatic melanoma cell line (B16F10) in vitro its anti-cancer vivo using a mouse model.MethodsWe investigated viability (Crystal Violet MTT assay) ability (wound-healing B16F10 cells, to trigger DNA damage (Comet vitro. We also sorted CD133+ CD133- cells from injected them subcutaneously into Swiss albino mice induce tumor formation. Tumor-bearing were divided control treatment groups. Treatment group...
There are more than 350 million people worldwide chronically infected with hepatitis B virus (HBV), who at high risk for the development of hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Because conflicting results about c-kit expression in HCC key role played by gastrointestinal stromal tumours (GIST) other solid tumours, aim this study was to determine course infection.Paraffin-embedded tissues Cukurova University Faculty Medicine Department Pathology between January 2002...
Neoadjuvant systemic chemotherapy is the accepted approach for women with locally advanced breast cancer. Anthracycline- and taxane-based regimens have been extensively studied in clinical trials consequently are widely used. In this study aimed to research complete response (pCR) rates different neoadjuvant setting determine associated biological factors.This included 63 patients diagnosed carcinoma among 95 that had treated between 2007 2010. TNM staging system was used staging. The...
Here we describe a case of Rosai-Dorfman Disease (RDD) in 25-year-old female patient from Turkey who was previously misdiagnosed with Toxoplasma Lymphadenitis, and review the manifestations treatment this rare entity. To best our knowledge is third description RDD [Sinus Histiocytosis Massive Lymphadenopathy (SHML)], involving bilateral cervical lymphadenopathy nephromegaly as Lymphadenitis. Representative clinical, radiographic histological findings are presented. Its etiology, diagnosis...
Background: Myeloid sarcoma rarely presents in the absence of systemic myeloid disease. Case Report: In this study, we present a case intracerebral with no diagnosis any hematological disease 22-year-old male patient whom brain magnetic resonance image revealed meningioma. However, biopsy showed sarcoma. No was determined. The mass disappeared following 8 cycles chemotherapy. literature, determined only similar cases cited between 1970 and 2011. Conclusion: Intracerebral has currently...