Necla Demir

ORCID: 0000-0002-9722-3459
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About
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Research Areas
  • Breast Cancer Treatment Studies
  • Advanced Breast Cancer Therapies
  • Chronic Lymphocytic Leukemia Research
  • Biochemical effects in animals
  • Cancer and Skin Lesions
  • HER2/EGFR in Cancer Research
  • Heart Rate Variability and Autonomic Control
  • Cancer Diagnosis and Treatment
  • Heart rate and cardiovascular health
  • Cancer Treatment and Pharmacology

Ankara Onkoloji Eğitim ve Araştırma Hastanesi
2025

Sağlık Bilimleri Üniversitesi
2024

Acıbadem University
2023-2024

There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor (CDK4/6) based therapy. We aimed to evaluate which oncologists prefer patients with disease progression under CDKi. In addition, we show the effectiveness of systemic treatments CDKi and whether there a survival difference between hormonal (monotherapy vs. mTOR-based).A total 609 from 53 centers were included study....

10.1186/s12885-023-10609-8 article EN cc-by BMC Cancer 2023-02-10

Background and Objectives: Breast cancer (BC) is the most prevalent globally, with a significant mortality rate, especially among women. While advances in treatment have reduced BC mortality, cardiovascular complications resulting from anticancer therapies become major concern. The autonomic nervous system (ANS) may be affected patients it assessed heart rate variability (HRV). aim of this study was to investigate prevalence impaired HRV, its predictors, clinical impacts patients. Materials...

10.3390/medicina61040608 article EN cc-by Medicina 2025-03-27

Abstract Background In the current study, effect of hormone receptor (HR) status on clinical and survival in early-stage human epidermal growth factor 2 (HER2)-positive breast cancer was investigated. Methods Two hundred ninety-one patients with HER2- positive were examined two categories as HR-positive HR-negative. Results Of these, 197 (68%) 94 (32%) HR-negative a mean follow-up period 68 ± 2.7 months. The groups found to be similar terms age, menopausal status, comorbidity, pathologic...

10.1093/jjco/hyae010 article EN Japanese Journal of Clinical Oncology 2024-02-09

Purpose: In this study, we investigated the clinical characteristics and survival outcomes of patients diagnosed with special types breast cancer who presented to our clinic. Material Methods: The demographic, clinicopathological, all rare, histologically subtype applied Cumhuriyet University Oncology Center between 2010 2020 were retrospectively reviewed. Results: records 1198 invasive examined, 104 them (8%) identified as having other histological subtypes. Of these, 19 had apocrine...

10.7197/cmj.1568420 article EN Cumhuriyet Tıp Dergisi/Cumhuriyet Üniversitesi Tıp Fakültesi dergisi 2024-11-08
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