A5024984311- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
- Inflammatory Biomarkers in Disease Prognosis
- COVID-19 and healthcare impacts
- Ovarian cancer diagnosis and treatment
- Gastric Cancer Management and Outcomes
- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
- Vascular Tumors and Angiosarcomas
- Esophageal Cancer Research and Treatment
- Urinary and Genital Oncology Studies
- Gastrointestinal Tumor Research and Treatment
- Prostate Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Renal cell carcinoma treatment
- COVID-19 Clinical Research Studies
- PARP inhibition in cancer therapy
- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi
2019-2023
Sağlık Bilimleri Üniversitesi
2019-2023
Istanbul Medeniyet University
2021
Pancreas cancer (PCa) is one of the mortal types with ranking as fourth leading death in both sexes together. FOLFIRINOX (FFX) and Gemcitabine plus nab-paclitaxel (GNP) are approved first-line metastatic treatment PCa. The aim this study was to compare clinical outcomes, treated FFX GNP Medical records patients diagnosed PCa, from January 2010 December 2020 were analyzed. This a retrospective cohort, multi-institution analysis. focus present efficiency chemotherapy combinations Efficacy had...
We aimed to investigate survival outcomes and survival-related prognostic factors in gastric cancer patients who were followed-up or received adjuvant therapy our center.Patients with treated between 2005 2016 evaluated retrospectively. included 345 non-metastatic (stage I-III) the study. The clinical, demographic, histologic data of treatment characteristics obtained from patient's files.While 50 stage I, 94 II, 201 III. While 221 (64%) presenting serosal adjacent visceral organ invasion...
The main objective is to define the mortality of patients with cancer admitted our hospital, their clinical and demographic characteristics, investigate risk COVID-19 for cancer, determine factors that affect rates dying COVID-19. A total 2401 were hospital diagnosis from March 11th, 2020, May 31st, 2020. Ninety-two out a 112 included in this study based on planned inclusion/exclusion criteria. clinical, demographic, laboratory features treatments provided studied, effect was analyzed. In...
Purpose We aimed to determine the COVID-19 infection rate and factors that affect hospitalization prognosis in patients receiving systemic chemotherapy (CT), immunotherapy (IT) molecular-targeted therapies at our hospital within three months after onset of pandemic. Materials methods The who received treatment unit with diagnosis cancer between 11 March 2020 June were included. clinical demographic characteristics patients, treatments they (CT, IT, targeted therapies), stage disease...
Background Ado-trastuzumab emtansine is an antibody-drug conjugate that combines the cytotoxic activity of with human epidermal growth factor receptor 2-targeted antitumor features trastuzumab. Objective We conducted a study metastatic breast cancer patients treated trastuzumab emtansine. By evaluating progression-free survival, overall and response rates, we aimed to find prognostic factors treatment. Methods Our single-center, retrospective, observational study. have clinical data from 78...
Abstract Purpose The aim of this study was to evaluate the efficacy abiraterone in patients with castration‐resistant metastatic prostate cancer. Materials and methods We retrospectively analyzed 51 mCRPC treated acetate from January 2014 August 2018. Clinicopathological information, treatment modalities, responses, survival times were reviewed. Results A total who received 1000 mg/day + prednisone 10 between 2018 included study. Of these patients, 33 (64.7%) had post‐chemotherapy (CT) 18...
Objective: To determine the relevance between cut-off level of cancer antigen 125 (CA 125) and long-term prognosis in high-grade serous ovarian (HGSCs).
Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate and its survival advantage has been shown in advanced human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, clinical trials underrepresent patients ⩾65 years of age, leading to a lack information this population. We analyzed the real-world outcomes older women who were treated with T-DM1 therapy.We performed multicenter, observational, retrospective analysis aged T-DM1. A total 93 from 10 cancer...
Background/aim: Oligometastatic disease for nonsmall cell lung cancer (NSCLC) patients is generally thought to represent a better prognosis with quieter biology, limited number of sites and long-term control. In this study, we aimed determine the efficacy radical treatment options oligometastatic NSCLC. Materials methods: This retrospective trial included totally 134 The presence oncodriver mutation, tumor stages nodal status, metastases involved metastatic site, primary oligometastasis,...
To evaluate the efficacy of bevacizumab a monoclonal, antivascular endothelial growth factor antibody in combination with cytotoxic chemotherapy Turkish patients recurrent and metastatic cervical cancer.Data 64 or cancer, receiving first-line cisplatin carboplatin paclitaxel between 2013 2017 were retrospectively evaluated.The mean age was 49 years (range, 28-68), median follow-up time 12 months 2-53), progression-free survival (PFS) eight months, overall (OS) 23 months. All received 6 1-12)...
Triple-negative-breast-cancer (TNBC) has a poor prognosis if pathologic complete response (pCR) cannot be achieved following neoadjuvant chemotherapy (NAC). The group of patients that benefit most from adjuvant capecitabine remains unclear.We analyzed data 160 consecutive with residual TNBC eight cancer-center. Pathologic was defined into two groups as having good-pathologic-response (MillerPayneGrading (MPG) IV-III) or poor-pathologic-response (MPG I-II). characteristics were compared...
Objective Prostate cancer is the second leading cause of death in men. Androgen deprivation therapy (ADT) has been primary therapeutic approach for treatment prostate cancer. However,nearly all patients develop castration-resistant disease . We evaluated real-world data with abiraterone and enzalutamide treatment. By this data, we aimed to analyze whether that prior short response ADT could predict subsequent androgen receptor axis targeted agent (ARATA). Material Method collected from two...
Introduction:For metastatic prostate cancer (PC), androgen deprivation therapy (ADT) is the primary treatment option.Most patients develop resistance, after an initial response to treatment.This study aimed evaluate real-life data of first-line docetaxel for castration-resistant (mCRPC) and analyzed whether time ADT could predict treatment.Methods: The included 111 with mCRPC who were treated docetaxel.Time castration resistance (TTCR) was defined as from initiation failure ADT.Patients...
Objectives: Ovarian cancer is associated with the highest mortality of gynecologic cancers. Epidemiological and genetic factors ovarian development are clearly defined but prognostic have not been adequately identified. Right left cancers seem to act different behaviors at high-grade serous (HGSOC) prognosis. The aim this study explain role its sidedness. Material methods: We reviewed 160 consecutive patients Figo stage 1-3 HGSOCs undergone surgery two high-volume hospitals. Prognostic...
ABS TRACT Objective: Pancreatic cancer (PCa) is the fourth leading cause of cancer-related deaths.Thus, there a need for prognostic indicators that can aid in disease classification and subsequent selection appropriate treatment options.Albumin-bilirubin (ALBI) grade, which calculated using logarithmic formula, indicative liver function.The present study evaluated performance initial ALBI grade metastatic PCa patients receiving first-line chemotherapy.Material Methods: In this retrospective...
Amaç: Tıp pratiğinde konsültasyon, tıbbın tüm dallarında vazgeçilmez bir uygulamadır. Özellikle patolojide, yakın zamana kadar genellikle yüz yüze yapılmıştır; ancak zamandaki COVID-19 salgını, fiziksel mesafe önlemleri, karantinalar ve evden çalışma düzenlemelerini zorunlu kıldı.
 Biz de hastanemizde kapanmanın sonrasının yoğun olduğu dönemde Zoom® video konferansı kullanarak konsültasyonu benimsemek zorunda kaldık. Bu ile İstanbul Medeniyet Üniversitesi Göztepe Eğitim Araştırma...
<h3>Introduction/Background</h3> General survival (GS) and clinical characteristics of the patients (NACT) undergoing interval debulking after neoadjuvant chemotherapy adjuvant primary surgery (PDS) were compared retrospectively among with FIGO stage 3 4 ovarian carcinoma. <h3>Methodology</h3> In this study, 141 who diagnosed or epithelial fallopian tube carcinoma between 2009 2017 had completed file data included. <h3>Results</h3> 73 (51.8%) 68 (48.2%) included in NACT PDS groups,...
Background/Aim: There is an unmet need for effective prognostic models in small cell lung cancer. Lung immune index (LIPI) and Modified Glasgow Prognostic Score (mGPS) markers are various cancers. We aimed to examine LIPI GPS markers' effects on overall survival (OS) extensive-stage small-cell cancer (SCLC) patients. Methods: Patients who were 18 years of age or older, diagnosed with carcinoma received platinum-based chemotherapy as first-line treatment included this retrospective...
Neoadjuvant chemotherapy (NACT) in gastroesophageal junction (GEJ) and gastric cancer (GC) was shown to improve survival recent studies. We aimed share our real-life experience of patients who received NACT compare the efficacy toxicity profile different regimens country. This retrospective multicentre study included locally advanced GC GEJ between 2007 2021. Relation CT pathological evaluation were analysed. A total 794 from 45 oncology centers Turkey included. Median age at time diagnosis...