A5037789511- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Neuroendocrine Tumor Research Advances
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Metastasis and carcinoma case studies
- Radiopharmaceutical Chemistry and Applications
- PI3K/AKT/mTOR signaling in cancer
- Advanced Breast Cancer Therapies
- Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Occupational and environmental lung diseases
- Reproductive System and Pregnancy
Istanbul Medipol University
2019-2025
GTx (United States)
2022
Weatherford College
2021
Kocaeli Üniversitesi
2012-2019
İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi
2019
Sağlık Bilimleri Üniversitesi
2019
Max Delbrück Center
2008
Charité - Universitätsmedizin Berlin
2008
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with limited treatment options. Identifying reliable prognostic biomarkers crucial for risk stratification and therapeutic decision-making. This study investigates the significance of Claudin 18.2 (CLDN18.2), isocitrate dehydrogenase-1 (IDH1) expression, neutrophil-to-lymphocyte ratio (NLR) in patients unresectable PDAC receiving first-line chemotherapy. retrospective, single-center included 72 histologically confirmed...
Background and Objectives: Epithelial ovarian cancer (EOC) remains a significant global health challenge. While traditional prognostic factors are well established, emerging biomarkers continue to gain attention. Materials Methods: This retrospective study evaluated the impact of systemic inflammatory markers on progression-free survival (PFS) overall (OS) in 154 EOC patients. Pre-treatment neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), index (SII) were calculated categorized...
Background: Extrapulmonary neuroendocrine carcinomas (EP-NECs) are rare, aggressive malignancies with no standardized treatment approach. Although platinum-based chemotherapy is considered the first-line therapy, overall survival (OS) and progression-free (PFS) remain limited. This study aims to evaluate clinical pathological characteristics of EP-NEC patients, their responses, outcomes. Methods: retrospective observational included 29 patients diagnosed followed between 2015 2024. Clinical...
Amaç: Hepatoselüler karsinom (HCC), dünya genelinde önemli bir sağlık sorunu olan karaciğer kanseridir. Çoğu hasta unrezektabl evrede tanı alır. Lokorejyonel tedaviler (LRT) ve sorafenib gibi sistemik tedaviler, HCC tedavisinde kullanılan yöntemlerdir. Bu çalışmada, LRT kombinasyonunun hastalarındaki etkinliği güvenilirliği retrospektif olarak araştırılmıştır. Gereç Yöntem: 2018-2023 yılları arasında İstanbul Medipol Üniversitesi Hastanesi'nde takip edilen 20 hastası çalışmaya dahil edildi....
Background/Objectives: This study aimed to investigate the prognostic and predictive significance of ATM expression in patients with metastatic non-small cell lung cancer (NSCLC) treated pembrolizumab. Methods: A retrospective analysis was conducted on 49 NSCLC who received first-line pembrolizumab as a single agent or combination chemotherapy. Immunohistochemistry used assess archival pathology specimens. Nuclear staining considered positive. categorized into low high groups based combined...
Background/Objectives: Extrapulmonary neuroendocrine carcinomas (EP-NECs) are rare, aggressive malignancies with no standardized treatment approach. Although platinum-based chemotherapy is considered the first-line therapy, overall survival (OS) and progression-free (PFS) remain limited. This study aims to evaluate clinical pathological characteristics of EP-NEC patients, their responses, outcomes. Methods: retrospective observational included 29 patients diagnosed followed between 2015...
Recent years have seen the start of treatment metastatic castration-resistant prostate cancer with prostate-specific membrane antigen (PSMA)–targeted radioligand therapy (PRLT), especially <sup>177</sup>Lu-PSMA-617. However, PRLT has side effects on salivary glands that limit safety treatment. The current study aimed to show effect external cooling ice packs <sup>177</sup>Lu-PSMA-617 uptake by parotid (PGs). <b>Methods:</b> included 19 patients (mean age, 72.9 y) who had been referred for...
Atezolizumab is now the standard treatment for extensive-stage small cell lung cancer (ES-SCLC). Herein, we investigated prognostic role of inflammatory markers in patients treated with atezolizumab plus chemotherapy and evaluated efficacy safety adding to ES-SCLC predictive factors as a real-life experience. This retrospective study included 55 who received front-line etoposide platin regimen ES-SCLC. We analyzed survival outcomes that may predict response survival. The objective rate (ORR)...
Lymph node involvement is an important prognostic factor in patients with gastric cancer. The aim of this study was to determine the significance metastatic lymph ratio (MLNR) and compare it number metastasis pN3 cancer.We retrospectively analyzed 207 cancer who had undergone radical gastrectomy. Prognostic factors MLNR were evaluated by univariate multivariate analysis.An 0.75 found be best cut-off value prognosis (p = 0.001). significantly higher large-sized undifferentiated tumors,...
Synovial sarcoma (SS) is a highly malignant tumor that accounts for 10% of all soft-tissue sarcomas. Primary SS arising from the lung extremely rare, and prognosis poor. We report case pulmonary presenting with mass lesion invading right upper middle lobes, extending to mediastinum chest wall. After tru-cut biopsy, surgical resection was performed. The final diagnosis (biphasic type) based on histological immunohistochemical findings. There are no guidelines optimal treatment due rarity...
To evaluate the prognostic utility of inflammation-based scores in patients with ALK-positive metastatic or non-resectable non-small-cell lung cancer (NSCLC) treated crizotinib. A total 82 NSCLC who received ALK TKI crizotinib were included. Pre-treatment modified Glasgow score (mGPS), nutritional index (PNI), and systemic immune-inflammation (SII) calculated. Multivariable logistic regression Cox proportional hazards models used to assess impact pretreatment mGPS, PNI, SII on overall...
The current study was designed to assess the response treatment, as well clinical and survival outcomes, across different breast cancer subtypes in patients who underwent neoadjuvant chemotherapy (NAC). From 2014 2019, a total of 139 were histologically confirmed have cancer, NAC, subsequently received axillary surgery, retrospectively included this study. rates pathological complete (pCR) NAC significantly higher for HER2-positive triple-negative than luminal A HER2-negative (p = 0.013)....
Abstract The aim of this study was to investigate the predictive and prognostic value PLR, relationship between PLR tumor localization. A total 229 patients with de-novo metastatic CRC were retrospectively analyzed. cutoff for defined by receiver operating characteristic (ROC) curve analysis threshold 196.5 as best cut-off found. higher rate BRAF mutation significantly detected high (> 196.5) compared those low (≤196.5) ( P = .001). in tumors located on right colon .012). localization,...
The aim of this study was to investigate the predictive value PLR and NLR as an indicator pathological complete response (pCR) in patients with breast cancer after NACT. One hundred thirty-nine early or LABC candidates NACT were retrospectively analyzed. prognostic significance In addition, indicators pCR also evaluated. obtained 48.9% patients. Significant difference detected between PLR, tumor grade, clinical lymph node status molecular subgroup. higher rate significantly achieved for low...
Patients with locally advanced breast cancer (LABC) should be treated neoadjuvant chemotherapy (NAC). Pathological complete response (pCR) is related to better disease-free survival (DFS). The best strategy for assessing the efficacy of NAC has not been established yet, but several studies have shown that 18F-FDG PET/CT a potential imaging tool pCR. aim this study investigate merits in predicting pCR both axillary and tissue establish threshold maximum standard uptake value (SUVmax) after...
Endobronchial involvement of extrapulmonary malignant tumors is uncommon and mostly associated with breast, kidney, colon, rectum carcinomas. A 68-year-old male a prior diagnosis colon non-Hodgkin lymphoma (NHL) was admitted to the hospital complaint cough, sputum, dyspnea. The chest radiograph showed right hilar enlargement opacity at middle zone suggestive mass lesion. Computed tomography thorax revealed right-sided lesion extending thoracic wall destruction third fourth ribs Fiberoptic...
Backgrounds and Objectives Colorectal cancer is one of the leading causes mortality both globally in our country. In Turkey, we conducted a multicenter investigation into effectiveness second-line treatments real-life data for patients with RAS wild-type metastatic colorectal (NCT04757311). Materials Methods this retrospective analysis, records from 28 centers were collected, histopathological, molecular, clinical characteristics documented. Patients categorized groups based on their...