A5056581193- Ovarian cancer diagnosis and treatment
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- Long-Term Effects of COVID-19
- Inflammatory Biomarkers in Disease Prognosis
- PARP inhibition in cancer therapy
- PI3K/AKT/mTOR signaling in cancer
- Colorectal Cancer Treatments and Studies
- Intraperitoneal and Appendiceal Malignancies
- Autophagy in Disease and Therapy
- Bladder and Urothelial Cancer Treatments
- Skin Protection and Aging
- Glioma Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Breast Cancer Treatment Studies
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Chronic Lymphocytic Leukemia Research
- Islanding Detection in Power Systems
- Vascular Malformations and Hemangiomas
- Bone health and treatments
- Pharmacological Effects of Natural Compounds
- Indoor Air Quality and Microbial Exposure
Hacettepe University
2023-2025
Hacettepe University Hospital
2023-2025
Weatherford College
2023
Universidad CES
2022
Kutahya Saglik Bilimleri Universitesi
2022
State Hospital
2022
Sivas State Hospital
2021
Background Dynamins are defined as a group of molecules with GTPase activity that play role in the formation endocytic vesicles and Golgi apparatus. Among them, DNM3 has gained recognition oncology for its tumor suppressor role. Based on this, aim this study is to investigate effects gene patients diagnosed pancreatic cancer using bioinformatics databases.
Background and Objectives: ROS1 rearrangement is a rare but targetable alteration in non-small-cell lung cancer (NSCLC), occurring 1–2% of cases. Crizotinib, tyrosine kinase inhibitor, has demonstrated efficacy clinical trials, real-world data remain limited. This study evaluates the safety crizotinib ROS1-rearranged NSCLC patients setting. Materials Methods: multicenter, retrospective research included 43 individuals with advanced/metastatic confirmed rearrangements. Patients were treated...
Background: Metastatic bladder cancer (mBC) presents a significant global health challenge with poor prognosis and considerably limited survival. Despite advancements in therapies, long-term survival remains difficult to predict. This study aimed evaluate the prognostic potential of various pretreatment blood-based biomarkers, including NLR, dNLR, LMR, PLR, SII, mGPS, CAR, AGR, PNI, PIV, Bellmunt score, mBC patients. Methods: A retrospective cohort 133 patients from Hacettepe University...
People socialize and receive education training for the first time outside home at school, where their teachers act as role models. Teachers play a crucial in instilling sun-protection habits children. Avoiding sun between 10 a.m. 4 p.m., staying shade, wearing sun-protective clothing, sunglasses, hats, using sunscreen products, an umbrella are some of methods described literature. This study sought to assess teachers' skin cancer knowledge attitudes (SC).In this cross-sectional conducted 21...
Aim Sirolimus, a mammalian target of rapamycin inhibitor, inhibits cell growth and proliferation by controlling ribosome biogenesis protein synthesis in vascular anomalies cancers. However, most sirolimus studies on were conducted the pediatric population, with limited data adults. In this study, we assessed effectiveness safety adult patients malformation, subtype anomaly. Methods We retrospective analysis malformation aged over 16, treated at Hacettepe University Cancer Institute from...
Aims: This study aimed to assess the habits and knowledge of cancer patients regarding use herbal medicines dietary supplements in receiving immune checkpoint inhibitors (ICI). Methods: The data 181 who were over 18 years old received ICIs collected. usage patterns, anticipated benefits harms, sources supply evaluated by filling researcher-prepared forms. Results: Most did not any kind medicine (91.2%) or (75.9%) during their immunotherapy. Boosting system is primary motivation for among...
In the REGOMA trial, regorafenib demonstrated an overall survival advantage over lomustine, and it has become a recommended treatment for recurrent glioblastoma in guidelines. This study aimed to evaluate effectiveness safety of as third-line patients with who progressed while taking bevacizumab-based therapy. retrospective, multicenter Turkey included 65 treated between 2021 2023 across 19 oncology centers. The main inclusion criteria were histologically confirmed isocitrate dehydrogenase...
Human epidermal growth factor receptor 2 (HER2)-targeting therapies have become crucial in the management of HER2-positive breast cancer. Trastuzumab emtansine (T-DM1) is a microtubule inhibitor and HER2-targeted antibody conjugate. T-DM1 resistance most likely influenced by factors involved biological mechanisms action. This study aimed to examine efficacy statins, which influence HER-2-based via caveolin-1 (CAV-1) protein, female cancer patients receiving T-DM1. Our included 105 with...
Aim: To assess the prognostic role of CA-125 elimination rate constant K (KELIM) score in platinum-resistant/refractory ovarian cancer patients receiving second-line treatment. Methods: A retrospective study was carried out including 117 with advanced-stage treated liposomal doxorubicin ± bevacizumab. The KELIM score, calculated using measurements within first 100 days chemotherapy, used. Survival analyses were performed for overall survival (OS) and progression-free (PFS). Results: Higher...
The fact that the human epidermal growth factor receptor 2 (HER2)-low group, historically classified as HER2 negative in breast cancer histology, benefited from HER2-targeted treatments similarly to HER2-positive group indicates this has a distinct histology HER2-0 group. effectiveness of cyclin-dependent kinase 4/6 inhibitors, which are standard first-line treatment for hormone receptor-positive, HER2-negative advanced cancer, newly defined histological subgroup remains topic debate. In our...
<title>Abstract</title> Background Denosumab, a RANK-ligand inhibitor, is an effectivetreatmentforfor bone metastasesfromsolidtumors.Unlikethebisphosphonates, it not excretedbythekidney. Little known, however, aboutitsefficacyandsafety in patientswith severe chronickidneydisease (CKD). Methods This study retrospective observational and was conducted as multicenter within the scope of Turkish Oncology Group (TOG) project. Patients with breast, prostate lung cancer who received denosumab...
Introduction More than a year has passed since the beginning of COVID-19 pandemic, and we are learning more about long-term effects disease. While many patients recover completely, some continue to experience fatigue, dyspnea, cough, joint pain, chest pain for weeks or even months (1).The UK National Institute Health […]
Background and Objectives: A high baseline neutrophil-to-lymphocyte ratio (NLR) is a poor prognostic factor in various cancers. However, its predictive role metastatic bladder cancer (mBC) treated with immunotherapy unclear. In this study, we aimed to investigate the relationship between change NLR overall survival mBC patients immunotherapy, potential significantly impact patient care. Materials Methods: retrospective analysis was conducted on 56 who received second-line after progressing...
Although immune checkpoint inhibitors (ICIs) are widely used in cancer treatment, identifying factors that predict treatment response remains a challenge clinical practice. There is need for biomarkers to identify patients who may not benefit from these treatments. It crucial simple and cost-effective biomarker can be easily incorporated into This study aims investigate the mean platelet volume lymphocyte ratio (MPVLR), as measured by hemogram test, median overall survival (mOS) with treated...
Objective: Early detection of mortality risk is important in patients diagnosed with coronavirus disease 2019 (COVID-19). Therefore, we aimed to evaluate the predictive value different clinical and laboratory parameters severity COVID-19. Materials Methods: Patients admitted hospital a diagnosis COVID-19 were evaluated retrospectively. The patients’ admission date, discharge intensive care transfer/ death contact history, smoking, symptoms at time admission, vital markers recorded. Results:...