A5017983979- Cystic Fibrosis Research Advances
- Cancer Immunotherapy and Biomarkers
- Testicular diseases and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- CAR-T cell therapy research
- Acute Kidney Injury Research
- Melanoma and MAPK Pathways
- Plant Micronutrient Interactions and Effects
- Muscle and Compartmental Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Cardiac tumors and thrombi
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Animal Nutrition and Physiology
- Glioma Diagnosis and Treatment
Ege University
2024-2025
Background/Objectives: There is an unmet need to improve outcomes in patients with metastatic Ewing sarcoma (ES). This retrospective, multicenter study aimed evaluate the efficacy and safety of topotecan–cyclophosphamide (TC) regimen adult ES who had previously been treated chemotherapy. Methods: enrolled 75 were at five oncology centers Turkey between 2011 2020. Patients TC regimen, consisting topotecan 0.75 mg/m2/day cyclophosphamide 250 mg/m2/day, given daily for 5 days repeated every 21...
Abstract Background Despite the success of immune checkpoint inhibitors (ICIs) in metastatic melanoma, many patients fail to derive meaningful benefit, underscoring urgent need for accessible prognostic biomarkers. The C-reactive protein (CRP)–albumin–lymphocyte (CALLY) index, an immunonutritional has shown value various cancers. Previous studies indicate that systemic inflammation and nutritional status influence ICI efficacy, suggesting potential relevance CALLY index melanoma. This study...
Background/Objectives: Nivolumab has been shown to be an effective treatment for metastatic renal cell carcinoma (mRCC); however, patient responses vary considerably. The objective of this study is evaluate the prognostic value C-PLAN index in predicting survival outcomes patients with mRCC treated nivolumab. Methods: This retrospective cohort included 81 previously tyrosine kinase inhibitors who subsequently received index, which includes C-reactive protein, performance status, lactate...
In the REGOMA trial, regorafenib demonstrated an overall survival advantage over lomustine, and it has become a recommended treatment for recurrent glioblastoma in guidelines. This study aimed to evaluate effectiveness safety of as third-line patients with who progressed while taking bevacizumab-based therapy. retrospective, multicenter Turkey included 65 treated between 2021 2023 across 19 oncology centers. The main inclusion criteria were histologically confirmed isocitrate dehydrogenase...
Summary The aim of this study was to examine the effects different levels dietary boron supplementation on live weight, feed intake, conversion ratio, carcass characteristics and some haematological, pathological antioxidant parameters in Japanese quail exposed stress by application stocking densities. A total 720 day-old chicks were placed cages with 75, 60 50 cm 2/bird density three per treatment. All fed for 6 weeks 0, 25, 75 mg/kg boron-added basal diets.
Hyperprogressive disease (HPD) is described as the unexpected rapid growth of a tumour accompanied by decline in performance status. While immune checkpoint inhibitors (ICIs) have improved outcomes advanced melanoma, HPD remains significant challenge subset patients. Although has been extensively studied various solid tumours, research specifically focusing on melanoma limited. We analysed 158 patients, with 66.5% (n = 105) receiving anti-PD-1 and 33.5% 53) nivolumab plus ipilimumab. The...
Introduction: The incidence of acute kidney injury is increasing in the elderly. This condition especially serious during course critical illness, and rate mortality rises with condition’s severity. We aimed to identify risk factors for in-hospital, 28-day, 90-day among elderly patients admitted intensive care unit requiring dialysis. Materials Method: conducted a retrospective study between January 2011 December 2019 65 years age older who were hospitalized dialysis an internal medicine...