Ayşe Ayzıt Kılınç
A5036326640- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Diaphragmatic Hernia Studies
- Pediatric health and respiratory diseases
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Airway Management and Intubation Techniques
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Family and Patient Care in Intensive Care Units
- Transplantation: Methods and Outcomes
- Pleural and Pulmonary Diseases
- Tuberculosis Research and Epidemiology
- COVID-19 and Mental Health
- Infant Development and Preterm Care
- Dysphagia Assessment and Management
- Child Nutrition and Water Access
- Systemic Sclerosis and Related Diseases
- Respiratory and Cough-Related Research
- Long-Term Effects of COVID-19
- Trauma Management and Diagnosis
- Inhalation and Respiratory Drug Delivery
- Pharmaceutical studies and practices
Istanbul University
2016-2025
Istanbul University-Cerrahpaşa
2019-2025
Rize Devlet Hastanesi
2013
Ondokuz Mayıs University
2011-2013
OBJECTIVE:The aims of this multi-center study were to describe the characteristics children receiving long-term home mechanical ventilation (HMV) in İstanbul and compare patients non-invasive invasive ventilation. MATERIAL AND METHODS:This cross-sectional multicenter included all HMV followed by admission six tertiary hospitals.The data collected between May 2020 2021.Demographic regarding from patient charts. RESULTS:The 416 participants.The most common diagnoses neuromuscular (35.1%)...
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) variants are essential for determining eligibility CFTR modulator drugs (CFTRms). In contrast to Europe and the USA, treatment profile of cystic fibrosis (CF) patients in Türkiye is not known. this study we aimed determine CF CFTRms. The Registry (CFrT) data was used age year 2021 genetic they were carrying. Age- CFTR-variant appropriate therapies determined using Vertex® algorithm. Among a total 1930 registered patients, CTFR gene...
Cystic fibrosis (CF) care has been implemented in Turkey for a long time; however, there had no patient registry. For this purpose, the Turkish National CF Registry was established. We present first results of registry using data collected 2017.The were data-entry software system, which accessed from internet. Demographic and annually recorded consisted 15 79 variables, respectively.There 1170 patients registered 23 centers; estimated coverage rate 30%. The median age at diagnosis 1.7 years...
Background: In April 2009 a novel strain of human influenza A, identified as H1N1 virus, rapidly spread worldwide, and in early June the World Health Organization raised pandemic alert level to phase 6. Herein we present largest series children who were hospitalized due infection Turkey. Methods: We conducted retrospective multicentre analysis case records involving with influenza-like illness, whom was diagnosed by reverse-transcriptase polymerase chain reaction assay, at 17 different...
Abstract Background Pseudo‐Bartter syndrome (PBS) is a rare complication of cystic fibrosis (CF) and there are limited data in the literature about it. We aimed to compare clinical features accompanying findings patients with PBS large patient population. Methods The were collected from Cystic Fibrosis Registry Turkey where 1170 CF recorded 2017. Clinical features, diagnostic test results, colonization status, complications, genetic results compared without PBS. Results Totally into registry...
Tracheostomy-related morbidity and mortality mainly occur due to decannulation, misplacement, or obstruction of the tube. A standardized training can improve skills confidence caregivers in tracheostomy care (TC).Our primary aim was evaluate efficiency program on knowledge (changing-suctioning tube) participants regarding TC.Sixty-five children with were included. First, evaluated written test about TC participated practical tests. Then, they asked participate a session, including...
Abstract Since the outbreak of Syrian civil war in 2011, population Arab refugees Turkey has rapidly increased. While cystic fibrosis (CF) is believed to be rare among Arabs, recent studies suggest it underdiagnosed. This study aims present demographic, clinical, and genetic characteristics CF patients Turkey. Additionally, a comparison made between findings National Registry 2021 (NCFRT) refugee patient group. The included ages 0 18 years who were diagnosed with received ongoing care at...
The complete blood count (CBC) parameters and the ratios regarding these have been demonstrated to be useful diagnostic biomarkers for many infectious diseases. Herein, we aimed evaluate compare usefulness of predictive role CBC in differential diagnosis pulmonary tuberculosis (TB) from community-acquired pneumonia (CAP) children. We also compared serum electrolyte levels between 2 In this retrospective study, analyzed efficacy neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte...
Abstract Background A better understanding of cystic fibrosis transmembrane conductance regulator biology has led to the development modulator drugs such as ivacaftor, lumacaftor‐ivacaftor, tezacaftor‐ivacaftor, and elexacaftor‐tezacaftor‐ivacaftor. This cross‐sectional study evaluated (CF) patients eligible for drugs. Methods Data age genetic mutations from Cystic Fibrosis Registry Turkey collected in 2018 were used find out number who are therapy. Results Of registered 1488 CF patients,...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a serious epidemic in our country and all over the world since December 2019 become global health problem. The disease by SARS-CoV-2 virus been named as coronavirus 19 (COVID-19).We report on epidemiological clinical features of 37 children diagnosed with COVID-19.The median age was 10 years 57.1% were male. In addition, 78.3% had history contact adult patients who COVID-19, 27.0% coexisting medical conditions. We found...
Abstract Background Since the COVID‐19 pandemic became a serious health concern globally, patients with chronic diseases have required close attention regard to general risks and individual treatment. We aimed reveal status of pediatric asthmatic during pandemic, considering role household factors in parental attitudes. Methods asked 60 their parents respond questionnaire, aim revealing current approach family asthma management pandemic. Results A total eight had an attack outbreak, but...
Abstract Background Cystic fibrosis (CF) transmembrane conductance receptor (CFTR)‐related disease is diagnosed in patients affected by CFTR dysfunction who do not fully meet the CF diagnostic criteria. Only 2% of all have CFTR‐related disease. We define demographic characteristics such patients, described performance mutational analyses, and describe clinical findings. Methods Twenty‐four were followed‐up for Patients with symptoms but did completely fulfil criteria enrolled. Age, body mass...
Abstract Background Cystic fibrosis (CF) causes malabsorption of nutrients that exacerbate pulmonary problems. Nutritional interventions can improve functions. We aimed to evaluate the effects nutritional intervention in CF patients with malnutrition, and determine if there is a correlation between status Methods The study included 143 (67 females) mean 2 year follow‐up time. Patients’ sociodemographic data, presenting symptoms history were recorded. Height‐for‐age, weight‐for‐age,...
Cough is an important defense and airway clearance mechanism for removing thick viscous secretions in cystic fibrosis (CF). The primary aim of this study was to investigate the effect expiratory muscle training (EMT) on peak cough flow (PCF) secondly respiratory functions, functional exercise capacity, quality life (QoL) CF.Thirty patients were randomized as sham groups. Both groups trained with EMT protocol, which involved twice per day at least 5 days week 6 weeks. intensity group 30%...
Predictors of early diagnosis and severe infection in children with coronavirus disease 2019 (COVID-19), which has killed more than 4 million people worldwide, have not been identified. However, some biomarkers, including cytokines chemokines, are associated the diagnosis, pathogenesis severity COVID-19 adults. We examined whether such biomarkers can be used to predict prognosis pediatric patients. Eighty-nine were included study, comprising three patient groups 69 patients (6 severe, 36...
Cystic fibrosis (CF) registries play an essential role in improving disease outcomes of people with CF. This study aimed to evaluate the association newly established CF registry system Turkey on follow-up, clinical, growth, treatment, and complications this disease.Age at diagnosis, current age, sex, z-scores weight, height body mass index (BMI), neonatal screening results, pulmonary function tests, history meconium ileus, medications, presence microorganisms, follow-up were evaluated...
Cystic fibrosis (CF) is an autosomal recessive disorder caused by CF transmembrane conductance regulator (CFTR) genetic variants. CFTR modulators improve pulmonary function and reduce respiratory infections in CF. This study investigated the clinical laboratory follow-up parameters over 1 year patients with who could not receive this treatment.This retrospective cohort included 2018 2019 patient data from registry of Turkey. Demographic characteristics 294 were assessed, had modulator...
Abstract Plasminogen deficiency is characterized by fibrin‐rich pseudomembrane formation on all mucosal surfaces, particularly the conjunctiva. Respiratory system involvement common; fibrin often obstructs upper or lower respiratory tract, causing death. Although many treatments have been applied, no definitive treatment (especially of involvement) yet exists. excision tracheobronchial tree membranes affords temporary improvement, this should be performed only for patients in severe...
Despite the availability of cystic fibrosis (CF) screening countrywide, diagnostic delay is still a crucial issue. The objectives this study were to explore stages NBS process, determine risk factors associated with and evaluate parent anxiety experience throughout process.This multicenter cross-sectional study. A questionnaire was completed by parents newborns diagnosed CF via in 17 centers. Socio-demographic characteristics, knowledge experiences related NBS, sweat test region residence,...