A5063377278- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Acute Kidney Injury Research
- Renal function and acid-base balance
- Kawasaki Disease and Coronary Complications
- Cardiovascular Function and Risk Factors
- Metabolism and Genetic Disorders
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Disease and Adiposity
- Pneumonia and Respiratory Infections
- Cardiac electrophysiology and arrhythmias
- Hemodynamic Monitoring and Therapy
- Pneumocystis jirovecii pneumonia detection and treatment
- Mechanical Circulatory Support Devices
- Central Venous Catheters and Hemodialysis
- Cardiac Arrhythmias and Treatments
- Electrolyte and hormonal disorders
- Respiratory viral infections research
- Drug-Induced Adverse Reactions
- Venous Thromboembolism Diagnosis and Management
- Pain Management and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
Istanbul University-Cerrahpaşa
2016-2024
Istanbul University
1993-2022
Okmeydanı Eğitim ve Araştırma Hastanesi
2018-2020
Intensive Care Society
2019
Başkent University
2014-2018
Sağlık Bilimleri Üniversitesi
2018
Mevlana University
2011-2015
Necmettin Erbakan University
2015
Bezmiâlem Vakıf Üniversitesi
2014
Bursa Uludağ Üni̇versi̇tesi̇
2014
Multi-system inflammatory syndrome in children (MIS-C) is a less understood and rare complication of coronavirus disease-2019 (COVID-19). Given the scarce data regarding this novel disease, we aimed to describe clinical features outcomes our patients with MIS-C evaluate associated factors for pediatric intensive care unit (PICU) admission.The under 18 years old diagnosed treated three referral centers between July 2020 March 2021 were included. Data retrospectively obtained from their...
Multisystem inflammatory syndrome in children (MIS-C) evolves some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcomes were previously correlated Notch4 expression on Tregs, here, we show that Tregs MIS-C destabilized through a Notch1-dependent mechanism. Genetic analysis revealed had enrichment of rare deleterious variants affecting inflammation autoimmunity pathways, including dominant-negative mutations...
Abstract Background: Chest pain, as a common cause of hospital admissions in childhood, necessitates detailed investigations due to wide range differential diagnoses. In this study, we aimed determine the distribution diseases causing chest pain children and investigate clinical characteristics with pain. Methods: This study included 782 patients aged between 3 18 years who presented paediatric cardiology outpatient clinic April 2017 March 2018. Aetiological causes demographic features were...
Novel coronavirus disease 2019 is a viral infectious which commonly involve the lungs with primarily radiologic manifestations of atypical or organizing pneumonia. It can cause multisystemic involvement including central nervous system symptoms. One these neurologic posterior reversible encephalopathy syndrome (PRES). suggested that increased levels cytokines and inflammatory mediators in course are responsible for cerebrovascular endothelial dysfunction disruption blood-brain barrier. To...
The aim of this study was to evaluate the thyroid function alterations in a group epileptic children taking antiepileptic drugs (AEDs). Patients demographic data and free throxine (fT4) thyroid-stimulating hormone (TSH) levels at beginning treatment third, sixth ninth months AED were recorded retrospectively. A total 106 children, 59 males 47 females, enrolled study. Mean patient age 3.7 years, ranging between 3 14 years. In total, 54% patients on valproic acid (VPA), 16% phenobarbital (PB),...
There have been some significant changes regarding healthcare utilization during the COVID-19 pandemic. Majority of reports about impact pandemic on diabetes care are from first wave We aim to evaluate potential effects severity diabetic ketoacidosis (DKA) and new onset Type 1 presenting with DKA, also children DKA acute infection. This is a retrospective multi-center study among 997 adolescents type who were admitted 27 pediatric intensive units in Turkey between year pre-pandemic year. The...
While Continuous Renal Replacement Therapy (CRRT) is a well established treatment modality for patients with acute kidney insufficiency (AKI), it now also being used the management of various illnesses such as metabolic disorders presenting hyperammonemia and elevated leucine levels. Herein, we aimed to describe our experience CRRT in decompensation 14 diagnosis disorder who has been admitted pediatric intensive care unit (PICU) last year.Patients have had life threatening crisis due were...
Abstract A limited number of cases thrombotic microangiopathy (TMA) have previously been reported in association with COVID‐19. Our report describes two TMA associated COVID‐19, one which was successfully treated eculizumab. The first case a 23‐month‐old girl, and the second 9‐month‐old boy. PCR tests for SARS‐CoV‐2 were positive both cases, laboratory results showed microangiopathic haemolytic anaemia, thrombocytopenia, acute kidney injury. No known aetiology found either case. Stool...
Children in paediatric intensive care units (PICUs) are vulnerable to infections because invasive devices frequently used during their admission. We aimed determine the prevalence, associated factors, and prognosis of our PICU. This retrospective study evaluated culture results from 477 patients who were treated PICU between January 2014 March 2019. Ninety (18.9%) had bacterial infections, with gram-negative bacteria being predominant infectious agents. Culture-positive younger than...
Background and objective: Severe sepsis septic shock are life-threatening organ dysfunctions causes of death in critically ill patients. The therapeutic goal the management is restoring balance to immune system fluid balance. Continuous renal replacement therapy (CRRT) recommended patients, it may improve outcomes patients with severe or shock. Therapeutic plasma exchange (TPE) another extracorporeal procedure that can function by decreasing inflammatory anti-fibrinolytic mediators...
Enhanced external counterpulsation (EECP) is a noninvasive treatment that proven safe and effective in patients with coronary artery disease (CAD) heart failure (HF). The aims of this study are to investigate the clinical effects EECP therapy symptomatic CAD chronic HF, find out an answer question: Does have any effect on prognostic markers HF?This was designed as prospective cohort study. A total 68 consecutive HF referred were enrolled between November 2007 December 2010; 47 (39 males 8...
We investigated the relationship between epicardial fat volume (EFV) measured by multislice computed tomography (MDCT) and long-term major adverse cardiac events (MACEs). Consecutive patients (n = 564) were enrolled in this retrospective study. Patients divided into tertiles according to EFV. followed up for an average of 18 months. each tertile similar terms gender risk factors. with greater EFV third group more likely be overweight (P .001) older .001). High-density lipoprotein cholesterol...
The complete blood count (CBC) parameters and the ratios regarding these have been demonstrated to be useful diagnostic biomarkers for many infectious diseases. Herein, we aimed evaluate compare usefulness of predictive role CBC in differential diagnosis pulmonary tuberculosis (TB) from community-acquired pneumonia (CAP) children. We also compared serum electrolyte levels between 2 In this retrospective study, analyzed efficacy neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte...
Abstract Candidemia is emerging as a significant concern in children, particularly among those with underlying conditions like malignancies or prematurity. The interpretation of epidemiological data on candidemias and their antifungal resistance plays vital role aiding diagnosis guiding clinicians treatment decisions. From 2014 to 2021, retrospective analysis was conducted İstanbul, Turkey; comparing Candida albicans non-albicans (NAC) spp both surviving deceased groups. Furthermore, an...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a serious epidemic in our country and all over the world since December 2019 become global health problem. The disease by SARS-CoV-2 virus been named as coronavirus 19 (COVID-19).We report on epidemiological clinical features of 37 children diagnosed with COVID-19.The median age was 10 years 57.1% were male. In addition, 78.3% had history contact adult patients who COVID-19, 27.0% coexisting medical conditions. We found...
Bacillus cereus can cause serious, life-threatening, systemic infections in immunocompromised patients. The ability of microorganism to form biofilm on biomedical devices be responsible for catheter-related bloodstream infections. Other manifestations severe disease are meningitis, endocarditis, osteomyelitis, and surgical traumatic wound most common feature true bacteremia caused by is the presence an intravascular catheter. Herein, we report a case B. patient with propionic acidemia.
We aimed to study electrocardiographic changes in children with diabetic ketoacidosis and ketosis evaluate the relation of serum electrolyte levels ketosis.This was performed Istanbul Medical Faculty, Pediatric Emergency Intensive Care Department between May 2008 2009. The parameters QT length were evaluated at diagnosis after treatment.Forty patients included study; 16 (40%) diagnosed as having 24 (60%) had ketoacidosis. Twenty-four male female mean age 9.21±4.71 years (range, 1-16 years)....
Chronic heart failure (CHF) has been associated with an increased risk of poorer cognitive performance in older adults. Reversibility impairment after medical treatment reported, although the restorative effects enhanced external counterpulsation (EECP) on have not studied. We investigated effect EECP functions CHF patients.Thirty-six individuals (mean age: 66±8 years) who were diagnosed and New York Heart Association (NYHA) Class II-III Canadian Cardiovascular Society (CCS) participated...
Some risk factors for atherosclerosis are followed by non-alcoholic fatty liver disease (NAFLD). We wanted to use Multislice computed tomography (MSCT) as technique searching relationship between NAFLD and coronary artery (CAD).The CAD was investigated using MSCT.A total of 372 individuals with or without cardiac symptoms who had undergone MSCT angiography were included in the study. The patients divided into two groups according presence NAFLD. Coronary segments visually evaluated via...
Introduction . Procalcitonin (PCT) and C-reactive protein (CRP) are already known predictive markers in serious bacterial infections, it is emphasized that these biomarkers can be used as a marker of increased mortality critically ill patients. Herein, we aimed to evaluate the initial serum PCT CRP levels on outcome patients pediatric intensive care units (PICUs) find out if predict mortality. Materials Methods. The relationship between invasive mechanical ventilation (IMV) noninvasive (NIV)...
Introduction: Peritoneal dialysis and continuous renal replacement therapy (CRRT) are the most frequently used treatment modalities for acute kidney injury. CRRT is currently being of several non-renal indications, such as congenital metabolic diseases. can efficiently remove toxic metabolites reverse neurological symptoms quickly. However, there not enough data in children with Therefore, we aimed a retrospective study to describe use diseases its associated efficacy, complications,...
In the past decade, multidrug-resistant (MDR) gram-negative bacteria have become a major problem, especially for patients in intensive care units. Recently, colistin became last resort therapy MDR infections. However, nebulised use was limited to adult patients. Thus, we investigated efficacy and safety of treatment against microorganisms paediatric unit (PICU). Data all admitted various critical illnesses (January 2016 January 2019) were reviewed. Differences between groups (with without...