A5037614319- Inflammasome and immune disorders
- interferon and immune responses
- Multiple Sclerosis Research Studies
- Autoimmune and Inflammatory Disorders Research
- Gene expression and cancer classification
- Attention Deficit Hyperactivity Disorder
- Systemic Lupus Erythematosus Research
- Autism Spectrum Disorder Research
- Ocular Diseases and Behçet’s Syndrome
- Bipolar Disorder and Treatment
- RNA Research and Splicing
- Extracellular vesicles in disease
- Adenosine and Purinergic Signaling
- Peptidase Inhibition and Analysis
- Genomics and Rare Diseases
- Autophagy in Disease and Therapy
- Neurotransmitter Receptor Influence on Behavior
- Otitis Media and Relapsing Polychondritis
- Obsessive-Compulsive Spectrum Disorders
- Connective tissue disorders research
- Bioinformatics and Genomic Networks
- Protein Tyrosine Phosphatases
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Gout, Hyperuricemia, Uric Acid
Acıbadem University
2021-2024
Istanbul Technical University
2012-2023
Kent Hastanesi
2022
Acıbadem Adana Hospital
2022
Ege University
2022
National Institute of Allergy and Infectious Diseases
2020
National Institutes of Health
2020
Istanbul Medeniyet University
2019
Medical University of Sofia
2017
Institut thématique Génétique, génomique et bioinformatique
2017
Abstract There are several reported associations between depressive disorders, panic disorder, and obsessive–compulsive disorder (OCD) a variety of polymorphisms in the monoamine oxidase A ( MAOA ) gene. Associations have also been catechol‐O‐methyltransferase COMT gene both OCD bipolar depression. However, role these markers has not explored for personality trait neuroticism (N), normally distributed quantitative trait, which is highly genetically correlated with anxiety depression may be...
Multiple sclerosis (MS) is characterized as an immune-mediated central nervous system disease marked by chronic inflammation, demyelination, and progressive neurodegeneration. In this study, we evaluated the contribution of low-frequency rare genetic variants to MS susceptibility within one largest family-based cohorts date, comprising 215 individuals from 59 Turkish multiplex families. Whole exome sequencing was conducted on all samples including affected unaffected members, followed...
MEFV mutations and decreased expression level of the gene are related to FMF pathology. DNA methylation at CpG islands is a well-known mechanism for transcriptional silencing. has island, spanning part first intron whole second exon covering 998 bp region. Here, we tested hypothesis that transcript in patients correlates with its level, methylation, by allowing transcription silencing, role ethiopathogenesis.The study group was composed pediatric (N = 51) age-gender matched healthy controls...
Background: The complex pathogenesis of multiple sclerosis, combined with an unpredictable prognosis, requires identification disease-specific diagnostic and prognostic biomarkers. Objective: To determine whether inflammatory proteins, such as neurofilament light chain, myelin oligodendrocyte glycoprotein basic protein, neurodegenerative tau glial fibrillary acidic can serve biomarkers for predicting the clinical subtype prognosis MS. Methods: Cerebrospinal fluid serum samples were collected...
Juvenile idiopathic arthritis is the most common chronic rheumatic disease in children, and its etiology remains poorly understood. Here, we explored four families with early-onset carrying homozygous loss-of-expression mutations LACC1. To understand link between LACC1 inflammation, performed a functional study of human immune cells. We showed that was primarily expressed macrophages upon mTOR signaling. found deficiency had no obvious impact on inflammasome activation, type I interferon...
Anti-apoptotic members of the Bcl-2 family proteins play central roles in regulation cell death glioblastoma (GBM), most malignant type brain tumor. Despite advances GBM treatment, there is still an urgent need for new therapeutic approaches. Here, we report a novel 4-thiazolidinone derivative BH3 mimetic, BAU-243 that binds to with high affinity. effectively reduced overall proliferation including subpopulation cancer-initiating cells contrast selective inhibitor ABT-199. While ABT-199...
Objective The objective of this study is to investigate the diagnostic utility microRNAs (miRNAs) for distinguishing between urine samples from patients with Diabetic Kidney Disease (DKD) and those Focal Segmental Glomerulosclerosis (FSGS). Methods In multicentric, cross-sectional investigation, we enrolled diagnosed DKD, individuals primary biopsy-proven FSGS, healthy controls. top 5 miRNAs (hsa-mir-21, hsa-mir-30a, hsa-mir-193a, hsa-mir-196a, hsa-mir-200a) were selected quantify in...
Biochemical and genetic studies of attention deficit hyperactivity disorder (ADHD) suggest that regulation catecholamine neurotransmission is a key factor in the aetiology disorder. In particular, it postulated an underactive dopamine system associated with this study we have tested hypothesis by screening clinical sample Turkish children combined subtype ADHD functional variant catecholamine-methyl-transferase (COMT) codes for high- low-activity variants enzyme. Using within-family tests...
Both direct and indirect evidence implicate excitatory amino acid neurotransmission in the aetiology of schizophrenia. The data are particularly suggestive for N-methyl-D-aspartate (NMDA) neurotransmission. Four six genes coding subunits neuronal NMDA receptor have been mapped. We studied segregation allele sharing markers these four regions a sample southern African Bantu-speaking families multiply affected with DSM-III-R This population was chosen because anthropological linguistic suggest...
Multiple sclerosis (MS) is an immune-mediated, neuro-inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS) with a heterogeneous clinical presentation course. There remarkable phenotypic heterogeneity in MS, molecular mechanisms underlying it remain unknown. We aimed to investigate further etiopathogenesis related pathways subclinical types MS using proteomic bioinformatics approaches cerebrospinal fluids patients clinically isolated syndrome, relapsing...
Background Predicting the long-term disability outcomes of multiple sclerosis (MS) cases is challenging. Objective We prospectively analysed our previous MS cohort with initial cerebrospinal fluid (CSF) proteomics data to reveal markers after 8.2±2.2 years follow-up. Methods Patients regular follow-up visits were assigned into two groups: those an age-related severity (ARMSS) score ≥5 (unfavourable course group, N = 27) and ARMSS <5 (favourable 67). A machine learning-based algorithm was...