A5076899423- Multiple Sclerosis Research Studies
- Genetic Neurodegenerative Diseases
- Peripheral Neuropathies and Disorders
- Pharmacological Effects and Toxicity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Epilepsy research and treatment
- Mitochondrial Function and Pathology
- Migraine and Headache Studies
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Genomic variations and chromosomal abnormalities
- Brain Metastases and Treatment
- Whipple's Disease and Interleukins
- Retinal and Optic Conditions
- Hepatitis Viruses Studies and Epidemiology
- Neurogenesis and neuroplasticity mechanisms
- Polyomavirus and related diseases
- Hepatitis B Virus Studies
- Lysosomal Storage Disorders Research
- Infectious Diseases and Tuberculosis
- Neurological disorders and treatments
- IL-33, ST2, and ILC Pathways
Erciyes University
2016-2025
Kayser (Italy)
2025
Intensive Care Society
2023
Neurology, Inc
2023
Bozok Universitesi
2018
The cover image is based on the article Utility of Optical Genome Mapping in Repeat Disorders by Mehmet Burak Mutlu et al., https://doi.org/10.1111/cge.14633 .
Multiple sclerosis (MS) is characterized as an immune-mediated central nervous system disease marked by chronic inflammation, demyelination, and progressive neurodegeneration. In this study, we evaluated the contribution of low-frequency rare genetic variants to MS susceptibility within one largest family-based cohorts date, comprising 215 individuals from 59 Turkish multiplex families. Whole exome sequencing was conducted on all samples including affected unaffected members, followed...
Sphingosine-1 phosphate receptor 1 (S1PR1) is expressed by lymphocytes and regulates their egress from secondary lymphoid organs. Innate cell (ILC) family has been expanded with the discovery of group 1, 2 3 ILCs, namely ILC1, ILC2 ILC3. ILC3 ILC1 have remarkable similarity to CD4+ helper T lineage members Th17 Th1, respectively, which are important in pathology multiple sclerosis (MS). Whether human ILC subsets express S1PR1 or respond its ligands not studied. In this study, we used...
The COVID-19 pandemic raised concern amongst clinicians that disease-modifying therapies (DMT), particularly anti-CD20 monoclonal antibodies (mAb) and fingolimod, could worsen in people with multiple sclerosis (pwMS). This study aimed to examine DMT prescribing trends pre- post-pandemic onset.
The aim of this study is to compare the white matter multiple sclerosis (MS) patients with healthy controls and monitor response treatment magnetic resonance spectroscopy (MRS). Fifteen 36 recently diagnosed MS never treated interferon β were included in study. In patient group, MRS was performed before treatment, at 6th 12th month after initiation once control group. Patient group divided into 3 groups randomly. Physical examination findings recorded as Expanded Disability Status Scale...
IL-22 is an alpha-helical cytokine which belongs to the IL-10 family of cytokines. produced by RORγt+ innate and adaptive lymphocytes, including ILC3, γδ T, iNKT, Th17 Th22 cells some granulocytes. receptor expressed primarily non-haematopoietic cells. critical for barrier immunity at mucosal surfaces in steady state during infection. Although knockout mice were previously shown develop experimental autoimmune encephalomyelitis (EAE), a murine model multiple sclerosis (MS), how temporal...
Background/aim: It is known that the correlation of pulmonary function tests (PFT) with muscle dysfunction insufficient. Here, we aimed to evaluate diaphragm functions in individuals Friedreich?s ataxia (FRDA) and examine its relationship respiratory parameters disease severity. Materials methods: This prospective study, conducted between November December 2022, at Erciyes University, included 14 genetically confirmed FRDA an age- gender-matched healthy control group eight individuals. We...
The differential diagnosis of young-onset progressive dementia is an issue that requires effort. Recording the family history and careful clinical evaluation are useful tools in diagnosis. In case genetic bases, definitive molecular analysis. We report consanguineous two patients presenting with characterized by behavioral changes bone cysts. Concomitant pathology inheritance pattern directed us to investigate TREM2 gene, for diagnosis, which resulted identification a causative mutation...
This study compares the nutritional status and physical activity levels of relapsing-remitting multiple sclerosis (RRMS) patients healthy people.The included 120 participants: 60 (MS) controls. RRMS diagnoses were made based on 2017 McDonald criteria. The food intake frequency questionnaire was administered to participants, their threeday records collected, determined, anthropometric measurements made. differences between groups analyzed using Mann-Whitney U test Pearson's exact chi-squared...
The differential diagnosis of young-onset progressive dementia is an issue that requires effort.Recording the family history and careful clinical evaluation are useful tools in diagnosis.In case genetic bases, definitive molecular analysis.We report consanguineous two patients presenting with characterized by behavioral changes bone cysts.Concomitant pathology inheritance pattern directed us to investigate TREM2 gene, for diagnosis, which resulted identification a causative mutation...
Friedreich's Ataxia (FRDA) is the most common form of autosomal recessive ataxia. The disease primarily results from a GAA trinucleotide repeat expansion within FXN gene in up to 97% patients. clinical presentation begins approximately between ages 5 and 15. major findings FRDA are progressive extremity gait Although it known that caused by low levels functional protein target tissues, there no effective treatment available for this pathology. However, significant improvements have been...