Marzena J. Fabis‐Pedrini
A5058252357- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Peripheral Neuropathies and Disorders
- Systemic Sclerosis and Related Diseases
- Psoriasis: Treatment and Pathogenesis
- Polyomavirus and related diseases
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- RNA regulation and disease
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and Retrovirus Studies
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Circadian rhythm and melatonin
- Ocular Diseases and Behçet’s Syndrome
- Full-Duplex Wireless Communications
- Plant Virus Research Studies
- Viral Infections and Immunology Research
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Fungal Plant Pathogen Control
- CNS Lymphoma Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
Murdoch University
2017-2025
Perron Institute for Neurological and Translational Science
2016-2024
The University of Western Australia
2015-2024
Sir Charles Gairdner Hospital
2013-2024
Queen Elizabeth II Medical Centre
2016-2024
Monash University
2024
The Royal Melbourne Hospital
2024
Box Hill Hospital
2024
Eastern Health
2024
Alfred Health
2024
We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence prevalence across the region populations differing ancestry.NMOSD is recently defined demyelinating disease central nervous system (CNS). The NMOSD has not been established.Centres managing patients with CNS reported clinical laboratory features that were suspicious for NMOSD. Testing aquaporin 4 antibodies was all suspected cases. From this group,...
Myelin oligodendrocyte glycoprotein (MOG) IgG seropositivity is a prerequisite for MOG antibody-associated disease (MOGAD) diagnosis. While significant proportion of patients experience relapsing disease, there currently no biomarker predictive course. We aim to determine whether MOG-IgG epitopes can predict course in MOGAD patients.
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The risk developing MS strongly influenced by genetic predisposition, and over 100 loci have been established as associated with susceptibility. However, biologically relevant variants underlying not defined for vast majority these loci, limiting power studies to define new avenues research development therapeutics. It therefore crucial that candidate susceptibility are carefully...
Abstract Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) is diagnosed by serum MOG‐immunoglobulin G (MOG‐IgG) in association with typical demyelination. 111/1127 patients paired CSF/serum samples were seropositive for MOG‐IgG. Only 7/1016 (0.7%) seronegative had CSF‐restricted While 3/7 longitudinally extensive transverse myelitis, four a confirmed alternate diagnosis (three multiple sclerosis, one CNS vasculitis). In national referral setting, MOG‐IgG low sensitivity...
Background The natural history of multiple sclerosis (MS) typically presents with the clinically isolated syndrome (CIS), an episode neurological symptoms caused by central nervous system inflammation or demyelination that does not fulfil diagnostic criteria for MS. Objective As preclinical studies have suggested exposure to ultraviolet radiation (UVR) could regulate development MS, Phototherapy CIS (PhoCIS trial) was established examine effects narrowband UVB phototherapy on patients CIS,...
Neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) show overlap in their clinical features. We performed an analysis of relapses with the aim determining differences between two conditions. Cases NMOSD age- sex- matched MS controls were collected from across Australia New Zealand. Demographic information, including relapse histories, recorded using a standard questionnaire. There 75 cases 101 controls. 328 375 Spinal cord optic neuritis attacks most common both MS....
Objective: This propensity score–matched analysis from MSBase compared the effectiveness of cladribine with interferon β, fingolimod or natalizumab. Methods: We identified all patients relapse-onset multiple sclerosis, exposure to study therapies and ⩾1-year on-treatment follow-up MSBase. Three pairwise analyses treatment outcomes over 1 year. The were hazards first relapse, disability accumulation improvement events. Sensitivity completed. Results: cohorts consisted 37 (cladribine), 1940...
Background: The prognostic significance of non-disabling relapses in people with relapsing-remitting multiple sclerosis (RRMS) is unclear. Objective: To determine whether early predict disability accumulation RRMS. Methods: We redefined mild MSBase as ‘non-disabling’, and moderate or severe ‘disabling’. used mixed-effects Cox models to compare 90-day confirmed events exclusively within 2 years RRMS diagnosis those no relapses; any disabling relapses. Analyses were stratified by...
The COVID-19 pandemic raised concern amongst clinicians that disease-modifying therapies (DMT), particularly anti-CD20 monoclonal antibodies (mAb) and fingolimod, could worsen in people with multiple sclerosis (pwMS). This study aimed to examine DMT prescribing trends pre- post-pandemic onset.
Women with multiple sclerosis (MS) are at risk of disease reactivation in the early postpartum period. Ocrelizumab (OCR) is an anti-CD20 therapy highly effective reducing MS activity. Data remain limited regarding use disease-modifying therapies (DMTs), including OCR, and activity during peripregnancy periods.
Clinically isolated syndrome (CIS) is a first episode of neurological symptoms that may precede diagnosis multiple sclerosis (MS). Therefore, studying individuals with CIS lead to breakthroughs in understanding the development and pathogenesis MS. In this study, serum levels immunoglobulin (Ig)G, IgA, IgM, IgG1–4 were measured 20 people compared those 10 healthy controls (HC) 8 Serum Ig a) time their conversion from MS, b) antibodies Epstein-Barr virus (EBV), c) frequencies T regulatory...
Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells from n=18 treatment-naive individuals with recently diagnosed (<120 days) for the phenotype T regulatory (Treg), follicular (Tfr), helper (Th), (Tfh) and B cells. Relative healthy controls (n=19), was...
Abstract Clinically isolated syndrome (CIS) is the earliest clinical episode in multiple sclerosis (MS). Low environmental exposure to UV radiation implicated risk of developing MS, and therefore, narrowband UVB phototherapy might delay progression MS people with CIS. Twenty individuals CIS were recruited, half randomised receive 24 sessions over a period 8 weeks. Here, effects on frequencies circulating immune cells immunoglobulin levels after are reported. Peripheral blood samples for all...
Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in clinical MRI features NMOSD MS means that distinguishing these conditions can be difficult. With aim evaluating diagnostic utility from MS, we have conducted a cross-sectional analysis imaging data developed predictive models to distinguish two conditions. lesions were identified defined through literature search. Aquaporin-4 (AQP4) antibody positive cases age-...
Background Autologous stem cell transplantation (ASCT) for progressive multiple sclerosis (MS) may reset the immune repertoire. Objective The objective of this paper is to analyse lymphocyte recovery in patients with MS treated ASCT. Methods Patients not responding conventional treatment underwent ASCT following conditioning high-dose cyclophosphamide and antithymocyte globulin. Lymphocyte subset analysis was performed before two years Neurological function assessed by EDSS three post-ASCT....
Background: Risk factors for multiple sclerosis (MS) include human leukocyte antigen (HLA)-DR and Epstein-Barr virus (EBV)-specific antibody responses, including an epitope within EBV nuclear 1 (EBNA-1) that is of recent interest. Objective: The objective this paper to assess case-control associations between MS risk anti-EBV levels as well HLA-DR profiles, gender age in a population-based cohort. Methods: Serological responses were measured 426 patients 186 healthy controls. typing was...
Clinically isolated syndrome (CIS) is the earliest clinical episode in multiple sclerosis (MS). A study of circulating cells from patients with CIS may help us understand transition to, and processes associated with, development MS.As immune cell activity can be determined by flux through metabolic pathways, mRNA expression l-tryptophan- l-arginine-catabolising enzymes, indoleamine 2,3-dioxygenase (IDO) 1 IDO2 arginase (ARG) ARG2, respectively, was compared between peripheral blood...
Fabry’s disease (FD) is a recognised mimic of multiple sclerosis (MS). It an X-linked storage lysosomal disorder with deficiency α-galactosidase A and enzyme replacement therapy available. Patients FD may satisfy modified McDonald criteria if the diagnosis has not been pursued. We present case in 65-year-old woman masquerading as benign MS for 40 years. She recurrent posterior circulation stroke-like symptoms, hearing loss acroparaesthesia, but typical radiological features on MRI brain....