A5074181957- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Cytokine Signaling Pathways and Interactions
- Skin and Cellular Biology Research
- Systemic Lupus Erythematosus Research
- RNA regulation and disease
- Amyotrophic Lateral Sclerosis Research
- Peripheral Neuropathies and Disorders
- Evolution and Genetic Dynamics
- Gastroesophageal reflux and treatments
- Parkinson's Disease Mechanisms and Treatments
- Prion Diseases and Protein Misfolding
- Immunotherapy and Immune Responses
- Acute Lymphoblastic Leukemia research
- Allergic Rhinitis and Sensitization
- Olfactory and Sensory Function Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- interferon and immune responses
- S100 Proteins and Annexins
- Diabetes Treatment and Management
- Dysphagia Assessment and Management
- Systemic Sclerosis and Related Diseases
- Cancer-related molecular mechanisms research
Medical University of Graz
2016-2023
University of Copenhagen
2021
Universitat Autònoma de Barcelona
2021
Universitat de Barcelona
2021
Universitat Pompeu Fabra
2021
University of North Carolina at Chapel Hill
2021
University of Belgrade
2021
St. Michael's Hospital
2021
University of Toronto
2021
Vall d'Hebron Institut de Recerca
2021
Abstract Neurofilament light (NfL) protein is a marker of neuro-axonal damage and can be measured not only in cerebrospinal fluid but also serum, which allows for repeated assessments. There still limited knowledge regarding the association serum NfL (sNfL) with age subclinical morphologic brain changes their dynamics normal population. We sNfL by single molecule array (Simoa) assay 335 individuals participating population-based cohort study after mean follow-up time 5.9 years (n = 103)....
To explore whether serum neurofilament light chain protein (NfL) levels are increased in patients with MRI-confirmed recent small subcortical infarcts (RSSI) compared to healthy controls and determine the subsequent course determinants of NfL a longitudinal manner.In prospectively collected group symptomatic an RSSI (n = 79, mean age 61 ± 11 years, 67% male), we analyzed brain MRI using Single Molecule Array (Simoa) assay at baseline 3 15 months after stroke. Community-dwelling age-...
Abstract Aims To characterize the pharmacokinetic and pharmacodynamic properties of once‐weekly insulin icodec in type 2 diabetes (T2D). Materials Methods In an open‐label trial, 46 individuals with T2D (18‐75 years; body mass index 18.0‐38.0 kg/m ; glycated haemoglobin ≤75 mmol/mol [≤9%]; basal insulin‐treated) received subcutaneous for ≥8 weeks at individualized doses, aiming a pre‐breakfast plasma glucose concentration 4.4 to 7.0 mmol/L (80‐126 mg/dL) on last three mornings each weekly...
Background: Cerebrospinal fluid (CSF) immunoglobulin free light chains (FLC) have been suggested as quantitative alternative to oligoclonal bands (OCB) in the diagnosis of multiple sclerosis (MS). However, little is known on their role predicting clinical and paraclinical disease progression, particularly early stages. Objective: To assess prognostic value FLC OCB-positive patients with clinically isolated syndrome (CIS) suggestive MS MS. Methods: We determined kappa (KFLC) lambda (LFLC) CSF...
To identify biomarkers associated with progressive phases of MS and neuroprotective potential.Combined analysis the transcriptional proteomic profiles obtained in CNS tissue during chronic experimental autoimmune encephalomyelitis (EAE) profile differentiation murine neural stem cells into neurons. Candidate were measured by ELISA CSF 65 patients (29 relapsing-remitting [RRMS], 20 secondary MS, 16 primary [PPMS]) 30 noninflammatory neurologic controls (NINCs).Integrative gene protein...
Background: Serum neurofilament light chain (sNfL) levels and peripapillary retinal nerve fiber layer (pRNFL) are both emerging biomarkers of neuro-axonal damage in multiple sclerosis (MS). However, data on the relation between sNfL pRNFL scarce. Objective: We aimed to determine with thinning a large cohort relapsing–remitting (RR) MS patients. Methods: identified 80 patients from prospective, 3-year observational study changes RRMS annual blood samples available. were measured using...
Serum neurofilament light chain (sNfL) is a promising biomarker of neuroaxonal damage in persons with multiple sclerosis (pwMS). In cross-sectional studies, sNfL has been associated disease activity and brain magnetic resonance imaging (MRI) changes; however, it still unclear to what extent particular high levels impact on subsequent evolution.sNfL was quantified by an ultrasensitive single molecule array (Simoa) 199 pwMS (median age = 34.2 years, 64.3% female) 49 controls. All underwent 3-T...
Abstract Intrathecal IgM production in multiple sclerosis (MS) is associated with a worse disease course. To investigate pathogenic relevance of autoreactive MS, CSF from two independent cohorts, including MS patients and controls, were screened for antibody binding to induced pluripotent stem cell-derived neurons astrocytes, panel CNS- related cell lines. primitive neuro-ectodermal tumour line discriminated 10% donors controls. Transcriptomes single producing B cells cell-binding sequenced...
Serum neurofilament light chain levels (sNfL) and impairment of olfactory function emerge as biomarkers in multiple sclerosis (MS). However, the relation between sNfL MS has not been investigated yet.We aimed to determine whether correlate with relapsing-remitting (RR) MS.We annually measured (Sniffin' Sticks test: Threshold (T) combined discrimination-identification (DI) score) 80 RRMS patients compared T DI scores.T scores significantly correlated at simultaneous measurement (-1.5 points,...
The role of cerebrospinal fluid (CSF) mitochondrial DNA (mtDNA) levels as biomarker in multiple sclerosis (MS) is unknown. We determined CSF mtDNA a cohort 237 individuals, including patients with MS and clinically isolated syndrome (CIS), inflammatory non-inflammatory neurological controls, cognitively healthy controls (HC). concentration was measured by droplet digital polymerase chain reaction. were increased all pathological conditions compared HC, though no differences observed between...
The increasing armamentarium of disease-modifying therapies in multiple sclerosis is accompanied by potentially severe adverse effects. cell-adhesion molecule CD62L, which facilitates leukocyte extravasation, has been proposed as a predictive marker for treatment tolerability. However, pre-analytical procedures might impact test results, thereby limiting its clinical usability. Whether the immediate analysis CD62L expression peripheral blood mononuclear cells can aid decision making yet...
Background: Oxidative stress-induced neuronal damage in multiple sclerosis (MS) results from an imbalance between toxic free radicals and counteracting antioxidants, i.e., antioxidative capacity (AOC). The relation of AOC to outcome measures MS still remains inconclusive. We aimed compare cerebrospinal fluid (CSF) serum early controls assess its correlation with clinical/radiological measures. Methods: determined (ability CSF patients inhibit 2,2′-azobis(2-amidinopropane)...
Natalizumab is a highly effective monoclonal antibody for the treatment of multiple sclerosis (MS), which can diffuse in different anatomical compartments, including cerebrospinal fluid (CSF) and milk.Starting from incidental detection natalizumab CSF MS patients, objective this study was to develope flow-cytometry-based assay apply it quantify body fluids, milk collected nursing patients over 180 days with neutralizing antibodies against natalizumab.CSF, sera samples were tested by...
Abstract Intrathecal IgM production in multiple sclerosis (MS) is associated with a worse disease course. To investigate pathogenic relevance of autoreactive MS, CSF from two independent cohorts, including MS patients and controls, were screened for antibody binding to induced pluripotent stem cell-derived neurons astrocytes, panel CNS-related cell lines. primitive neuro-ectodermal tumour line discriminated 10% donors controls. Transcriptomes single producing B cells cell-binding sequenced...