A5083549305- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Genetic Neurodegenerative Diseases
- Cerebrospinal fluid and hydrocephalus
- Cardiac Imaging and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Folate and B Vitamins Research
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Neurological and metabolic disorders
- Blood Pressure and Hypertension Studies
- Amyotrophic Lateral Sclerosis Research
- Immune Response and Inflammation
- Cerebral Palsy and Movement Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Vitamin D Research Studies
Medical University of Graz
2016-2025
Graz University of Technology
2010-2023
Statistics Austria
2014-2022
Institute for Medical Informatics and Biostatistics
2021
MRC Biostatistics Unit
2020
King's College London
2020
Newcastle University
2020
University of Cambridge
2020
Radboud University Nijmegen
2020
Radboud University Medical Center
2020
Abstract Neurofilament light (NfL) protein is a marker of neuro-axonal damage and can be measured not only in cerebrospinal fluid but also serum, which allows for repeated assessments. There still limited knowledge regarding the association serum NfL (sNfL) with age subclinical morphologic brain changes their dynamics normal population. We sNfL by single molecule array (Simoa) assay 335 individuals participating population-based cohort study after mean follow-up time 5.9 years (n = 103)....
To explore whether serum neurofilament light chain protein (NfL) levels are increased in patients with MRI-confirmed recent small subcortical infarcts (RSSI) compared to healthy controls and determine the subsequent course determinants of NfL a longitudinal manner.In prospectively collected group symptomatic an RSSI (n = 79, mean age 61 ± 11 years, 67% male), we analyzed brain MRI using Single Molecule Array (Simoa) assay at baseline 3 15 months after stroke. Community-dwelling age-...
Cerebral small vessel disease is the most common cause of vascular cognitive impairment and typically manifests with slowed processing speed. We investigated impact lesion location on speed in age-related disease.A total 584 community-dwelling elderly underwent brain MRI followed by segmentation white matter hyperintensities. Processing was determined timed measure Trail Making Test part B. The hyperintensities assessed voxel-based lesion-symptom mapping graph-based statistical models...
ABSTRACT Background In a small group of patients, we have previously shown that combination electrophysiological tests was able to distinguish functional (psychogenic) tremor and organic with excellent sensitivity specificity. Objectives This study aims validate an test battery as tool diagnose patients “laboratory‐supported” level certainty. Methods For this prospective data collection study, recruited 38 new (mean age 37.9 ± 24.5 years; mean disease duration 5.9 9.0 years) 73 55.4 25.4...
Background Deep gray matter structures in patients with Alzheimer disease (AD) contain higher brain iron concentrations. However, few studies have included neocortical areas, which are challenging to assess MRI. Purpose To investigate baseline and change levels using MRI at 3 T R2* relaxation rate mapping individuals AD compared healthy control (HC) participants. Materials Methods In this prospective study, participants recruited between 2010 2016 age-matched HC selected from 2014 were...
<h3>Objective</h3> To determine whether a simple small vessel disease (SVD) score, which uses information available on rapid visual assessment of clinical MRI scans, predicts risk cognitive decline and dementia, above that provided by measures. <h3>Methods</h3> Three prospective longitudinal cohort studies (SCANS [St George9s Cognition Neuroimaging in Stroke], RUN DMC [Radboud University Nijmegen Diffusion Imaging Magnetic Resonance Cohort], the ASPS [Austrian Stroke Prevention Study]),...
Aging | doi:10.18632/aging.203790. Marisa Koini, Lukas Pirpamer, Edith Hofer, Arabella Buchmann, Daniela Pinter, Stefan Ropele, Christian Enzinger, Pascal Benkert, David Leppert, Jens Kuhle, Reinhold Schmidt, Michael Khalil
ABSTRACT Background and hypothesis It remains unclear whether the relation of chronic kidney disease (CKD) with cognitive dysfunction is independent blood pressure (BP). We evaluated function in to premorbid BP measurements, cerebral small vessel (CSVD), incident mild impairment (MCI) dementia Framingham Offspring Cohort participants. Methods included participants free dementia, attending an examination during midlife (exam cycle 6, baseline) for ascertainment status, brain magnetic...
Owing to a lack of data, our aim was evaluate and compare the impact various common neurological diseases on risk for falls in independent community dwelling senior citizens.Prospective case-controlled study.General hospital.Of 298 consecutive patients 214 controls enrolled, 228 (aged 74.5±7.8; 61% women) 193 71.4±6.8; 63% were included. The exclusion criteria as follows: patients, severe disability, disabling general condition or cognitive impairment; controls, any history disorders medical...
<h3>Objective:</h3> To investigate whether greater cardiorespiratory fitness is associated with better global and domain-specific cognitive function. <h3>Methods:</h3> We investigated 877 participants (aged 65 ± 7 years, 55% women) of the Austrian Stroke Prevention Study. For fitness, maximum oxygen consumption (V̇o<sub>2</sub>max) was calculated based on weight resting heart rate a treadmill test (mL·kg<sup>−1</sup>·min<sup>−1</sup>). A battery assessing memory (Bäumler9s Lern-und...
Abstract Introduction Impact of white matter hyperintensities (WMH) on cognition likely depends lesion location, but a comprehensive map strategic locations is lacking. We aimed to identify these in large multicenter study. Methods Individual patient data (n = 3525) from 11 memory clinic cohorts were harmonized. determined the association WMH location with attention and executive functioning, information processing speed, language, verbal performance using voxel‐based region interest...
Abstract INTRODUCTION White matter hyperintensities (WMH) are associated with key dementia etiologies, in particular arteriolosclerosis and amyloid pathology. We aimed to identify WMH locations vascular risk or cerebral amyloid‐β 1‐42 (Aβ42)‐positive status. METHODS Individual patient data ( n = 3,132; mean age 71.5 ± 9 years; 49.3% female) from 11 memory clinic cohorts were harmonized. volumes 28 regions related a compound score (VRCS) Aß42 status (based on cerebrospinal fluid positron...
The size of the human head is highly heritable, but genetic drivers its variation within general population remain unmapped. We perform a genome-wide association study on (N = 80,890) and identify 67 loci, which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, most have widespread effects. Gene set enrichment observed for various cancers p53, Wnt, ErbB signaling pathways. Genes harboring lead enriched macrocephaly syndrome genes (37-fold) high-fidelity...
Abstract Background and purpose Atrial fibrillation (AF) often remains undiagnosed in cryptogenic stroke (CS), mostly because of limited availability cardiac long‐term rhythm monitoring. There is an unmet need for a pre‐selection CS patients benefitting from such work‐up. A clinical risk score was therefore developed the prediction AF after its performance evaluated over 1 year follow‐up. Methods Our proposed ranges 0 to 16 points comprises variables known be associated with occult including...
To identify new genetic regulators of cellular aging and senescence, we performed genome-wide comparative RNA profiling with selected human model systems, reflecting replicative stress-induced premature distinct other forms aging. Gene expression profiles were measured, analyzed, entered into a newly generated database referred to as the GiSAO database. Bioinformatic analysis revealed set candidate genes, conserved across majority models, which so far not associated aging, highlighted...
Magnetization transfer imaging (MTI) can detect microstructural brain tissue changes and may be helpful in determining age-related cerebral damage. We investigated the association between magnetization ratio (MTR) gray white matter cognitive functioning 355 participants of Austrian Stroke Prevention Family Study (ASPS-Fam) aged 38 to 86 years. MTR maps were generated for neocortex, deep structures, hyperintensities, normal appearing matter. Adjusted mixed models determined whole lobar...
Higher white matter hyperintensity (WMH) load has been reported in Alzheimer's disease (AD) patients different brain regions when compared to controls. We aimed assess possible differences of WMH spatial distribution between AD and age-matched controls by means lesion probability maps.The present study included MRI scans 130 probable with a mean age 73.4±8.2 years from the Prospective Dementia Registry Austria Study healthy (HC) Austrian Stroke Prevention Family Study. Risk factors such as...
It has been suggested that diffusion tensor imaging (DTI) measures sensitive to white matter (WM) damage may predict future dementia risk not only in cerebral small vessel disease (SVD), but also mild cognitive impairment. To determine whether DTI were associated with cognition cross-sectionally and predicted across the full range of SVD severity, we established International OPtimising mulTImodal MRI markers for use as surrogate trials Vascular Cognitive Impairment due cerebrAl vesseL...
DTI is sensitive to white matter (WM) microstructural damage and has been suggested as a surrogate marker for phase 2 clinical trials in cerebral small vessel disease (SVD). The study's objective establish the best way analyse diffusion-weighted imaging data SVD this purpose. ideal method would be change predict dementia conversion, but also straightforward implement ideally automated. As part of OPTIMAL collaboration, we evaluated five different analysis strategies across six cohorts with...