A5103132128- Cerebrovascular and genetic disorders
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced MRI Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- NMR spectroscopy and applications
- Functional Brain Connectivity Studies
- Metalloenzymes and iron-sulfur proteins
- Nuclear Physics and Applications
- ECG Monitoring and Analysis
- Prenatal Substance Exposure Effects
- Cell Adhesion Molecules Research
- Folate and B Vitamins Research
- Neonatal and fetal brain pathology
- Atrial Fibrillation Management and Outcomes
- Medical Imaging and Analysis
- Non-Destructive Testing Techniques
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Characterization and Applications of Magnetic Nanoparticles
- Retinal and Optic Conditions
Université Paris Cité
2013-2019
Délégation Paris 7
2013-2019
Inserm
2014-2019
Sorbonne Paris Cité
2013-2019
Hôpital Lariboisière
2014-2019
Assistance Publique – Hôpitaux de Paris
2014-2019
Munich Cluster for Systems Neurology
2016-2017
Ludwig-Maximilians-Universität München
2014-2016
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2013-2016
Medical University of Graz
2014-2016
Magnetic resonance imaging has proved to be suitable and efficient for in vivo investigation of the early process brain gyrification fetuses preterm newborns but question remains as whether cortical-related measurements derived from both cases are comparable or not. Indeed, developmental folding trajectories drawn up populations have not been compared so far, neither cross-sectional nor longitudinal datasets. The present study aimed compare features cortical between healthy imaged on a...
Background/aim Currently, the equipment and techniques available to assess brain function during dynamic exercise are limited, which has restricted our knowledge of how regulates exercise. This study assessed areas activated cycling by making use a novel cycle ergometer, constructed measure functional MRI (fMRI) images Furthermore, we compared activation at different levels ratings perceived exertion (RPE) generated Methods Seven healthy adults performed in compatible ergometer while...
Abstract Prenatal alcohol exposure is responsible for a broad range of brain structural malformations, which can be studied using magnetic resonance imaging (MRI). Advanced MRI methods have emerged to characterize abnormalities, but the teratogenic effects on cortical morphology received little attention date. Twenty‐four 9‐year‐old children with fetal spectrum disorders (9 syndrome, 15 heavy exposed nonsyndromal children) and 16 age‐matched controls were assess effect consumption during...
Background and Purpose— Previous pathological studies in humans or animal models have shown alterations of small arteries veins within white matter lesions cerebral vessel disease. We aimed to evaluate vivo, the integrity venous network using high-resolution MRI both outside hyperintensities autosomal-dominant arteriopathy with subcortical infarcts leukoencephalopathy (CADASIL). Methods— High-resolution T 2 *-weighted images were obtained at 7-T 13 CADASIL patients no only mild symptoms age-...
Cerebral microbleeds are associated with an increased risk of intracerebral hemorrhage. Recent data suggest that may also predict the incident ischemic stroke. However, these results were observed in elderly individuals undertaking various medications and for whom causes stroke differ. We aimed to test relationship between presence CADASIL (Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy)-a severe monogenic small vessel disease known be responsible both...
Background and Purpose— Previous studies in cerebral autosomal dominant arteriopathy with subcortical infarcts leukoencephalopathy showed that accumulation of lacunes strongly relate to clinical severity. However, the potential predictors incident their consequences over a short time frame have not been investigated. This study aimed determine impact such lesions large cohort patients. Methods— Two hundred six NOTCH3 mutation carriers (mean age, 49.5±10.6 years) were followed up 3 years....
In Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), by contrast to sporadic cerebral small vessel disease related age hypertension, white matter hyperintensities (WMH) are frequently observed in the of anterior temporal poles, external capsules, superior frontal regions. Whether these WMH (specific WMH) differ from those other areas (nonspecific remains unknown. Twenty patients were scanned compare specific nonspecific using...
Background and Purpose— Recently, in a mouse model of cerebral autosomal-dominant arteriopathy with subcortical infarcts leukoencephalopathy, monogenic small vessel disease, intramyelinic edema was detected the white matter (WM) early during course disease. We hypothesized that if this mechanism holds true patients, it would translate larger WM volume. aimed to measure volume patients leukoencephalopathy comparison age- sex-matched controls, along ratio cortical surface area brain...
Previous studies showed that various types of cerebral lesions, as assessed on MRI, largely contribute to the clinical severity CADASIL. However, impact longitudinal changes classical markers small vessel disease conventional MRI has been only poorly investigated. One hundred sixty NOTCH3 mutation carriers (mean age ± SD, 49.8 10.9 years) were followed over three years. Validated methods used determine percent brain volume change (PBVC), number incident lacunes, white matter hyperintensities...
Background: The assessment of early and subtle cognitive behavioral effects cerebral small vessel disease (SVD) requires specific long-lasting evaluations performed by experienced neuropsychologists. Simpler tools would be helpful for daily clinical practice. Objective: To determine wh ether a simple reaction time task that lasts 5 minutes can without external supervision on any tablet or laptop used as proxy alterations in CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical...
Objective: In CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), white matter hyperintensities (WMH) are considered to result from hypoperfusion. We hypothesized that in fact the burden of WMH results combination several regional populations different mechanisms clinical consequences. Methods: To identify populations, we used a 4-step approach. First, an unsupervised principal component algorithm determine, without priori knowledge, main...
<h3>Objective:</h3> To obtain simple models predicting disease evolution at 3 years for a given patient with cerebral autosomal dominant arteriopathy subcortical infarcts and leukoencephalopathy (CADASIL). <h3>Methods:</h3> Based on data obtained in prospective study of 236 patients, we built validated predicting, the individual level, 3-year changes Mini-Mental State Examination (MMSE), Mattis Dementia Rating Scale (MDRS), Trail Making Test version B (TMTB), modified Rankin (mRS). These...
Abstract Background Atrial fibrillation (AF) is commonly reported in the general population and associated with significant mortality morbidity. While easy to use smartphone-based portable devices exist record 1-lead ECG, ability of commercially available software automatically detect AF using those remains limited poor positive predictive value (PPV). Purpose We aimed conduct an external validation existing cloud-based deep learning platform for automatic detection a large cohort patients...
Background and Purpose Recent data suggest that early symptoms may be related to cortex alterations in CADASIL (Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts Leukoencephalopathy), a monogenic model of cerebral small vessel disease (SVD). The aim this study was investigate cortical using both high-resolution T2* acquisitions obtained 7 Tesla MRI structural T1 images 3 patients no or only mild symptomatology (modified Rankin's scale ≤1 Mini Mental State Examination (MMSE)...