A5027755785- Economic and Financial Impacts of Cancer
- Palliative Care and End-of-Life Issues
- Cancer Genomics and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Research Data Management Practices
- Scientific Computing and Data Management
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Multiple Myeloma Research and Treatments
- Oral health in cancer treatment
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Colorectal Cancer Treatments and Studies
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Biomedical and Engineering Education
- Lung Cancer Research Studies
- Privacy, Security, and Data Protection
- Immunotherapy and Immune Responses
- AI in cancer detection
- Cryptography and Data Security
- Statistical Methods in Clinical Trials
Aalborg University Hospital
2018-2025
Aalborg University
2018-2024
Faculty (United Kingdom)
2018-2019
In a per-protocol analysis of molecularly profiled patients with treatment-refractory, end-stage cancer discussed at the National Molecular Tumor Board (NMTB), we aimed to assess overall survival (OS) outcome targeted treatment compared no treatment.
Background The selection of patients with non-small cell lung cancer (NSCLC) for immune checkpoint inhibitor (ICI) treatment remains challenging. This real-world study aimed to compare the overall survival (OS) before and after implementation ICIs, identify OS prognostic factors, assess data in first-line (1L) ICI-treated without epidermal growth factor receptor mutation or anaplastic lymphoma kinase translocation. Methods Data from Danish NSCLC population initiated 1L palliative...
Our goal was to describe a precision medicine program in regional academic hospital, characterize features of included patients and present early data on clinical impact.We prospectively 163 eligible with late-stage cancer any diagnosis from June 2020 May 2022 the Proseq Cancer trial. Molecular profiling new or fresh frozen tumor biopsies done by WES RNAseq parallel sequencing non-tumoral DNA as individual reference. Cases were presented at National Tumor Board (NMTB) for discussion targeted...
Background Radiation-therapy (RT) induces mucositis, a clinically challenging condition with limited prophylactic interventions and no predictive tests. In this pilot study, we applied global gene-expression analysis on serial human oral mucosa tissue blood cells from patients tonsil squamous cell cancer (TSCC) to identify genes involved in mucositis pathogenesis. Methods findings Eight TSCC each provided consecutive buccal biopsies before, after 7 days of RT treatment, 20 following RT. We...
Within recent years, many precision cancer medicine initiatives have been developed. Most of these focused on solid cancers, while the potential for patients with hematological malignancies, especially in relapse situation, are less elucidated. Here, we present a demographic unbiased and observational prospective study at Aalborg University Hospital Denmark, referral site 10% Danish population. We developed workflow based sequencing analysis whole exome tumor DNA RNA. All steps involved...
The Danish National Patient Registry is a major resource for epidemiology. Only few studies have been conducted to check the validity of reporting systemic anticancer treatments. In this study, we assessed range cancer types over long period time.We extracted treatment procedures from patients with solid malignant tumors treated at Department Oncology Aalborg University Hospital between 2009 and 2019 (12,014 215,293 drug records). These data were compared records obtained antineoplastic...
PURPOSE Administering systemic anticancer treatment (SACT) to patients near death can negatively affect their health-related quality of life. Late SACT administrations should be avoided in these cases. Machine learning techniques could used build decision support tools leveraging registry data for clinicians limit late administration. MATERIALS AND METHODS Patients with advanced lung cancer who were treated at the Department Oncology, Aalborg University Hospital and died between 2010 2019...
Abstract Despite the recent progress in treatment of multiple myeloma (MM), it is still an incurable malignant disease, and we are therefore need new risk stratification tools that can help us to understand disease optimize therapy. Here propose a subtyping plasma cells (PCs) from diagnostic samples, assigned by normal B-cell subset associated gene signatures (BAGS). For this purpose, combined fluorescence-activated cell sorting expression profiles bone marrow (BM) Pre-BI, Pre-BII, immature,...
Risk factors for systemic anticancer therapies (SACTs) administered close to death derived from existing quality indicators are not directly applicable in the clinic, because they condition on future events, which leads selection bias. This study aimed adapt a previously suggested indicator its use clinical context and evaluate it real-world, population-based cohort of cancer patients.An improved version '30-day mortality after SACT' by Wallington et al. (Lancet Oncol 2016; 17:1203-16) was...
ABSTRACT Objectives To facilitate clinical implementation and research in precision oncology, notably the pairing of patients, variants treatments to identify candidates for trials, we have built a data infrastructure 1) capture store data, 2) reduce manual tasks genomic collection management, 3) combine quality controls, reporting findability. Infrastructure The uses REDCap repositories data. structure these is customized each project. Additionally, cross-project web platform was developed...
Abstract Background Patients with hematological cancer who experience relapse or progressive disease often face yet another line of treatment and continued mortality risk that could increase their physical emotional trauma worsen health-related quality life. Healthcare professionals use patient-reported outcomes to identify will have specific sensitivities in particular life domains may be able individualize target supportive care, both features precision medicine. Here, a cohort patients...
Background: Reconstructing patient treatment trajectories is important to generate real-world evidence for epidemiological studies.The Danish National Patient Registry (DNPR) contains information about drug prescriptions and could therefore be used reconstruct trajectories.We aimed evaluate enhance two existing methods systemic anticancer trajectories.Methods: This study was based on data from 8738 consecutive patients with solid tumors treated in the North Denmark Region between 2009...
What is your preferred presentation method?: Oral (if accepted) or Poster Aim(s): For up to 3/4 of cancer patients, initial treatments are not effective, which leads into a trial and error treatment strategy resulting in unnecessary side effects waste health care resources.However, little documented about the costs associated with these secondary while large part limited hospital resources used for them.Our goal develop economics methods calculate cost order evaluate potential savings...