A5034265922- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- RNA regulation and disease
- MRI in cancer diagnosis
- Atomic and Subatomic Physics Research
- Machine Learning in Healthcare
- Parkinson's Disease Mechanisms and Treatments
- Ultrasound and Hyperthermia Applications
- Nuclear Physics and Applications
- Neurological and metabolic disorders
- Medical Imaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Neurological disorders and treatments
- Hydrogen embrittlement and corrosion behaviors in metals
- Advanced NMR Techniques and Applications
- Prion Diseases and Protein Misfolding
- Cell Image Analysis Techniques
- Electron Spin Resonance Studies
- Amyotrophic Lateral Sclerosis Research
- Systemic Lupus Erythematosus Research
- NMR spectroscopy and applications
- Radiomics and Machine Learning in Medical Imaging
- Neural dynamics and brain function
Medical University of Graz
2015-2024
BioTechMed-Graz
2021-2022
University of Graz
2018-2019
Harvard University
2015-2016
Athinoula A. Martinos Center for Biomedical Imaging
2015-2016
University of California, San Diego
2015
Beth Israel Deaconess Medical Center
2015
Ludwig Boltzmann Institute for Digital Health and Prevention
2010-2012
Ludwig Boltzmann Institute for COPD And Respiratory Epidemiology
2011-2012
Quantitative susceptibility mapping (QSM) is a novel technique which allows determining the bulk magnetic distribution of tissue in vivo from gradient echo resonance phase images. It commonly assumed that paramagnetic iron predominant source variations gray matter as many studies have reported reasonable correlation with brain concentrations vivo. Instead performing direct comparisons, however, all these used putative hallmark study by Hallgren and Sourander (1958) for their analysis....
To investigate the relationship between transverse relaxation rates R2 and R2*, most frequently used surrogate markers for iron in brain tissue, chemically determined concentrations.This study was approved by local ethics committee, informed consent obtained from each individual's next of kin. Quantitative magnetic resonance (MR) imaging performed at 3.0 T seven human postmortem brains situ (age range death, 38-81 years). Following extraction, concentrations were with inductively coupled...
Purpose To apply quantitative susceptibility mapping (QSM) in the basal ganglia of patients with multiple sclerosis (MS) and relate findings to R2* regard sensitivity for clinical morphologic measures disease severity. Materials Methods The local ethics committee approved this study, all subjects gave written informed consent. Sixty-eight (26 clinically isolated syndrome, 42 relapsing-remitting MS) 23 control underwent 3-T magnetic resonance (MR) imaging. Susceptibility maps were...
As indicated by several recent studies, magnetic susceptibility of the brain is influenced mainly myelin in white matter and iron deposits deep nuclei. Myelination deposition evolve both spatially temporally. This evolution reflects an important characteristic normal development ageing. In this study, we assessed changes regional human vivo examining developmental ageing process from 1 to 83 years age. The over lifespan was found display differential trajectories between gray matter....
Quantitative susceptibility mapping (QSM) and R2* relaxation rate have demonstrated increased iron deposition in the substantia nigra of patients with idiopathic Parkinson's disease (PD). However, findings other subcortical deep gray matter nuclei are converse sensitivity QSM for morphological changes their relation to clinical measures severity has so far been investigated only sparsely.The local ethics committee approved this study all subjects gave written informed consent. 66 58 control...
Purpose The aim of the 2016 quantitative susceptibility mapping (QSM) reconstruction challenge was to test ability various QSM algorithms recover underlying from phase data faithfully. Methods Gradient‐echo images a healthy volunteer acquired at 3T in single orientation with 1.06 mm isotropic resolution. A reference map provided, which computed using tensor imaging algorithm on 12 head orientations. Susceptibility maps calculated were compared against map. Deviations quantified following...
Abstract This article provides recommendations for implementing QSM clinical brain research. It is a consensus of the International Society Magnetic Resonance in Medicine, Electro‐Magnetic Tissue Properties Study Group. While technical development continues to advance rapidly, current methods have been demonstrated be repeatable and reproducible generating quantitative tissue magnetic susceptibility maps brain. However, many approaches available generated need neuroimaging community...
Parkinson's disease (PD) is a common neurodegenerative disease, and apart from few rare genetic causes, its pathogenesis remains largely unclear. Recent scientific interest has been captured by the involvement of iron biochemistry disruption homeostasis, particularly within brain regions specifically affected in PD. The advent Quantitative Susceptibility Mapping (QSM) enabled non-invasive quantification vivo MRI, which contributed to understanding iron-associated potential for development...
MR phase images have shown significantly improved contrast between cortical gray and white matter regions compared to magnitude obtained with gradient echo sequences. A variety of underlying biophysical mechanisms (including iron, blood, myelin content, macromolecular chemical exchange, fiber orientation) been suggested account for this observation but assessing the individual contribution these factors is limited in vivo. For a closer investigation iron induced susceptibility changes,...
<h3>Objectives:</h3> Abnormal high cerebral iron deposition may be implicated in chronic neurologic disorders, including multiple sclerosis (MS). R2* relaxometry has been recently validated a postmortem study to indicate brain accumulation quantitative manner. We used this technique assess levels different stages of MS and healthy controls (HC) determined their relation with demographic, clinical, neuropsychological, other imaging variables. <h3>Methods:</h3> studied 113 consecutive patients...
Post‐mortem MRI of the brain is increasingly applied in neuroscience for a better understanding contrast mechanisms disease induced tissue changes. However, influence chemical processes caused by formalin fixation and differences temperature may hamper comparability with results from vivo MRI. In this study we investigated how affect T 1 , 2 * relaxation times tissue. Fixation effects were examined respect to changes water content crosslinking. Relaxometry was performed slices five deceased...
Background Deep gray matter structures in patients with Alzheimer disease (AD) contain higher brain iron concentrations. However, few studies have included neocortical areas, which are challenging to assess MRI. Purpose To investigate baseline and change levels using MRI at 3 T R2* relaxation rate mapping individuals AD compared healthy control (HC) participants. Materials Methods In this prospective study, participants recruited between 2010 2016 age-matched HC selected from 2014 were...
Background Increased iron deposition has been implicated in the pathophysiology of multiple sclerosis (MS), based on visual analysis signal reduction T 2 -weighted images. R * relaxometry allows to assess brain accumulation quantitatively. Objective To investigate regional patients with a clinically isolated syndrome (CIS) or relapsing–remitting MS (RRMS) and its associations demographical, clinical, conventional magnetic resonance imaging (MRI) parameters. Methods We studied 69 (CIS, n =...
Background: Lesion dissemination in time and space represents a key feature diagnostic marker of multiple sclerosis (MS). The correlation between magnetic resonance imaging (MRI) lesion load disability is only modest, however. Strategic location might at least partially account for this ‘clinico-radiologic paradox’. Objectives: Here we used non-parametric permutation-based approach to map probability based on MS lesions identified T2-weighted MRI. We studied 121 patients with clinically...
Axonal damage is considered a major cause of disability in multiple sclerosis (MS) and may start early the disease. Specific biomarkers for this process are great interest.To study if cerebrospinal fluid (CSF) axonal reflect predict disease progression already earliest stages disease, that is, clinically isolated syndrome (CIS).We assessed CSF levels neurofilament heavy (NFH), light (NFL) N-acetylaspartate (NAA) 67 patients with CIS 18 controls neuropsychiatric diseases non-inflammatory...
<h3>Objective:</h3> We investigated longitudinal changes in iron concentration the subcortical gray matter (caudate nucleus, globus pallidus, putamen, thalamus) of patients with clinically isolated syndrome (CIS) and definite multiple sclerosis (MS) their relation to clinical other morphologic variables. <h3>Methods:</h3> followed 144 (76 CIS; median Expanded Disability Status Scale [EDSS] 1.0 [interquartile range (IQR) 0.0–2.0]; 68 MS; EDSS 2.0 [IQR 1.0–3.3]) 3T MRI over a period 2.9 (IQR...
Purpose The aim of the second quantitative susceptibility mapping (QSM) reconstruction challenge (Oct 2019, Seoul, Korea) was to test accuracy QSM dipole inversion algorithms in simulated brain data. Methods A two‐stage design chosen for this challenge. participants were provided with datasets multi‐echo gradient echo images synthesized from two realistic silico head phantoms using an MR simulator. At first stage, optimized reconstructions without ground truth data available mimic clinical...
Purpose To create a realistic in silico head phantom for the second QSM reconstruction challenge and future evaluations of processing algorithms QSM. Methods We created digital whole‐head tissue property by segmenting postprocessing high‐resolution (0.64 mm isotropic), multiparametric MRI data acquired at 7 T from healthy volunteer. simulated steady‐state magnetization using Bloch simulator mimicked Cartesian sampling scheme through Fourier‐based processing. Computer code generating...