A5064895935- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Lymphoma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Brain Tumor Detection and Classification
- Functional Brain Connectivity Studies
- Lanthanide and Transition Metal Complexes
- Radiomics and Machine Learning in Medical Imaging
- Neuroscience and Neural Engineering
- Topic Modeling
- Electron Spin Resonance Studies
- Vascular Tumors and Angiosarcomas
- Molecular Biology Techniques and Applications
- Ocular Oncology and Treatments
- Neural dynamics and brain function
- Data-Driven Disease Surveillance
- Biomedical Text Mining and Ontologies
- Pelvic floor disorders treatments
- Cerebrospinal fluid and hydrocephalus
- Chromatin Remodeling and Cancer
- Older Adults Driving Studies
Emory University
2022-2024
University of Alabama at Birmingham
2018-2022
University of Alabama at Birmingham Hospital
2022
University of Illinois Chicago
2016-2017
University of Iowa
2007-2015
University of Iowa Hospitals and Clinics
2008-2009
Yale University
2006
Hartford Hospital
2006
Purpose The aim of the 2016 quantitative susceptibility mapping (QSM) reconstruction challenge was to test ability various QSM algorithms recover underlying from phase data faithfully. Methods Gradient‐echo images a healthy volunteer acquired at 3T in single orientation with 1.06 mm isotropic resolution. A reference map provided, which computed using tensor imaging algorithm on 12 head orientations. Susceptibility maps calculated were compared against map. Deviations quantified following...
Low-grade gliomas (LGG) invade the brains of young and productive adults leading to significant neurological morbid-ity. Mutations in isocitrate dehydrogenase (IDH) gene are very common LGG. Because IDH1 inhibitors ef-fective treatment LGG, early detection growth is critical initiating therapy without delay. This retrospec-tive observational study evaluates ability AI-assisted volumetric analysis correctly detect tumor lon-gitudinal studies LGG as compared standard clinical method visual...
Glioblastomas (GBM) grow rapidly and infiltrate the cerebral parenchyma, leading to significant neurological morbidity mortality. Early detection of tumor growth promotes early therapeutic interventions that delay progression possibly prolong survival times. This retrospective observational study evaluates ability AI-assisted volumetric analysis correctly detect in longitudinal studies newly diagnosed GBM, compared standard clinical method visual inspection by radiologists neuro-oncologists....
Diffusion tensor imaging was used to study brain related changes in white matter that may be associated with Huntington's Disease progression. Thirty-one preclinical gene-mutation carriers were imaged cross-sectionally using diffusion and anatomical imaging. Subjects individuals who had a known gene mutation for HD but did not manifest motor diagnostic criteria HD. Fractional anisotropy scalar maps showed positive correlation five year probability of diagnosis (based upon repeat length...
The Response Assessment in Neuro-Oncology (RANO) criteria for lower-grade gliomas (LGGs) define tumor progression as ≥25% change the T2/FLAIR signal area based on an operator's discretion of perpendicular diameter largest cross-section. Potential sources error include acquisition inconsistency 2D slices, operator selection variabilities both representative cross-section and measurement line locations, inability to quantify infiltrative margins satellite lesions. Our goal was assess accuracy...
Radiology reports contain information that can be mined using a search engine for teaching, research, and quality assurance purposes. Current engines look exact matches to the term, but they do not differentiate between in which term appears positive context (i.e., being present) from those of negation uncertainty. We describe RadReportMiner, context-aware engine, compare its retrieval performance with generic Google Desktop. created corpus 464 radiology described at least one five findings...
Diffusion kurtosis imaging (DKI) can offer a useful complementary tool to routine diffusion MRI for improved stratification of heterogeneous tissue damage in acute ischemic stroke. However, its relatively long time has hampered clinical application the emergency setting. A recently proposed fast DKI approach substantially shortens time, which may help overcome scan limitation. date, sensitivity protocol stroke not been fully described. In this study, we performed and scans rodent model...
In Sturge-Weber syndrome in neonates, evaluation of the extent brain parenchymal involvement is difficult due to lack calcification, although it important for initiation preventive antiepileptic treatment and prediction prognosis. We present first application diffusion-tensor imaging with fractional anisotropy ADC maps a 7-day-old neonate. Abnormal T2 hypointensity subcortical white matter corresponded areas increased FA decreased on imaging, which probably represents abnormal...
Abstract Background and Purpose Diffusion kurtosis imaging (DKI) is an advanced technique more specific to irreversible ischemic injury than conventional diffusion‐weighted (DWI). However, its clinical translation has been limited by a long acquisition time complex postprocessing. Methods A fast DKI sequence (3 minutes) was implemented on 3T MRI (Siemens Trio) piloted as part of inpatient brain protocol. Mean (MK) mean diffusivity (MD) maps were postprocessed automatically at the scanner...
We report two cases of epithelioid hemangioma (EH) manifested in the thoracic spine with associated clinical, radiographic, and pathological findings. Epithelioid is a benign vascular tumor that can involve any bone (including subset patients). Although recognized as by WHO, it display locally aggressive features. Within spine, these features may lead to pain, instability, and/or neurologic dysfunction. The radiographic appearance most typically lytic, well-defined lesion on plain film or...
Glioblastoma (GBM) is the most common malignant adult brain and has a poor prognosis. Routine post-treatment MRI evaluations are required to assess treatment response disease progression. We present case of an 83-year-old female who underwent assessment GBM after intravenous iron replacement therapy, ferumoxytol. The revealed unintended alteration signal characteristics from containing agent which confounded diagnostic interpretation subsequently, planning. Ferumoxytol injection prior...
Patients diagnosed with glioblastoma multiforme (GBM) continue to face a dire prognosis. Developing accurate and efficient contouring methods is crucial, as they can significantly advance both clinical practice research. This study evaluates the AI models developed by MRIMath© for GBM T1c fluid attenuation inversion recovery (FLAIR) images comparing their contours those of three neuro-radiologists using smart manual platform. The mean overall Sørensen-Dice Similarity Coefficient metric score...
Objectives To describe an extremely rare case of sporadic hemangioblastoma (HB) within the cavernous sinus and Meckel's cave with extension to cerebellopontine angle (CPA) cistern. Methods A 73-year-old male presented hearing loss, unilateral ptosis, facial numbness. Results The imaging showed a complex cystic-solid mass centered at left CPA Patient underwent retrosigmoid craniectomy for partial resection component mass. Surgical pathology confirmed diagnosis HB patient was scheduled...
Background Carbon dioxide is a potent cerebral vasodilator that may influence outcomes after ischemic stroke. The objective of this study was to investigate the effect intraprocedural mean end-tidal CO2 (ETCO2) levels on core infarct expansion and neurologic outcome following thrombectomy for anterior circulation Methods A retrospective review conducted consecutive patients from March 2020 June 2021 who underwent mechanical acute stroke under general anesthesia achieved successful...
Diffusion imaging provides the ability to study white matter connectivity and integrity noninvasively. weighted contains orientation information that must be appropriately reoriented when applying spatial transforms resulting data. Alexander et al. have introduced two methods resolve reorientation problem. In first method, rotation matrix is computed from transform tensors are reoriented. The second method called as preservation of principal direction (PPD) takes into account deformation...
Schizophrenia is a serious and disabling mental disorder. Diffusion tensor imaging (DTI) studies performed on schizophrenia have demonstrated white matter degeneration either due to loss of myelination or deterioration fiber tracts although the areas where changes occur are variable across studies. Most population based analyze in using scalar indices computed from diffusion such as fractional anisotropy (FA) relative (RA). The measures may not capture complete information tensor. In this...
Abstract Background: Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a ubiquitous, multifunctional 37 kDa enzyme best known for catalyzing the sixth step in glycolysis. GAPDH expression so consistent that it has been granted “housekeeping” status, and used as standard (along with β-actin) normalizing Western blots. While increased described hypoxia, diabetes, some cancers, decreased rare. Here we describe new human glioblastoma cell line exhibits loss, while maintaining high degree of...