A5052397756- Genetic Neurodegenerative Diseases
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Mitochondrial Function and Pathology
- Advanced Neuroimaging Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Psychology of Moral and Emotional Judgment
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Child and Animal Learning Development
- Radiomics and Machine Learning in Medical Imaging
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related cognitive impairment studies
- Death Anxiety and Social Exclusion
- Action Observation and Synchronization
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Decision-Making and Behavioral Economics
- Mental Health Research Topics
- Meta-analysis and systematic reviews
- Hemispheric Asymmetry in Neuroscience
- Cleft Lip and Palate Research
University of Arkansas for Medical Sciences
2023-2024
Arkansas Children's Hospital
2023-2024
University of Iowa
2008-2023
University of Iowa Hospitals and Clinics
2018-2022
University of Glasgow
2020-2021
University of Toronto
2012-2020
Queen Elizabeth University Hospital
2020
Summary Data analysis workflows in many scientific domains have become increasingly complex and flexible. To assess the impact of this flexibility on functional magnetic resonance imaging (fMRI) results, same dataset was independently analyzed by 70 teams, testing nine ex-ante hypotheses. The analytic approaches is exemplified fact that no two teams chose identical to analyze data. This resulted sizeable variation hypothesis test even for whose statistical maps were highly correlated at...
BackgroundNo consensus exists in the clinical transcranial magnetic stimulation (TMS) field as to best method for targeting left dorsolateral prefrontal cortex (DLPFC) depression treatment. Two common methods are Beam F3 and 5.5 cm rule.ObjectiveEvaluate anatomical reliability of technician-identified DLPFC targets obtain average brain scalp MNI152 coordinates.MethodsThree trained TMS technicians performed repeated using both rule ten healthy subjects (n = 162). Average target locations were...
Abstract We hypothesized that the ventromedial pFC (vmPFC) is critical for making transitive inferences (e.g., logical operation if A > B and C, then C). To test this, participants with focal vmPFC damage, brain-damaged comparison participants, neurologically normal completed a inference task consisting an ordered set of arbitrary patterns. Participants first learned through trial-and-error relationships patterns Pattern B, After initial learning, were presented novel pairings, some...
Abstract Background Automated segmentation of individual calf muscle compartments in 3D MR images is gaining importance diagnosing disease, monitoring its progression, and prediction the disease course. Although deep convolutional neural networks have ushered a revolution medical image segmentation, achieving clinically acceptable results challenging task availability sufficiently large annotated datasets still limits their applicability. Purpose In this paper, we present novel approach...
Diffusion tensor imaging was used to study brain related changes in white matter that may be associated with Huntington's Disease progression. Thirty-one preclinical gene-mutation carriers were imaged cross-sectionally using diffusion and anatomical imaging. Subjects individuals who had a known gene mutation for HD but did not manifest motor diagnostic criteria HD. Fractional anisotropy scalar maps showed positive correlation five year probability of diagnosis (based upon repeat length...
Abstract Aneurysm wall enhancement (AWE) after the administration of contrast gadolinium is a potential biomarker unstable intracranial aneurysms. While most studies determine AWE subjectively, this study comprehensively quantified in 3D imaging using semi-automated method. Thirty patients with 33 unruptured aneurysms prospectively underwent high-resolution 7T-MRI. The signal intensity (SI) aneurysm was mapped and normalized to pituitary stalk (PS) corpus callosum (CC). CC proved be more...
Background Aneurysm wall enhancement (AWE) is a potential surrogate biomarker for aneurysm instability. Previous studies have assessed AWE using 2D multiplanar methods, most of which were conducted qualitatively. Objective To use new quantitative tool to analyze large cohort saccular aneurysms with 3D-AWE maps Methods Saccular imaged prospectively 3T high resolution MRI. symptomatic (defined as ruptured or presentation sentinel headache/cranial nerve neuropathy) and asymptomatic created by...
Background: Few adequately-powered studies have systematically evaluated brain morphology in adult-onset myotonic dystrophy type 1 (DM1).Objective: The goal of the present study was to determine structural differences between individuals with and without DM1 a multi-site, case-controlled cohort.We also explored correlations structure CTG repeat length.Methods: Neuroimaging data acquired 58 unaffected (29 women) 79 (50 women).CTG length, expressed as estimated progenitor allele length (ePAL),...
Inflammation of the arterial wall may lead to aneurysm formation. The presence enhancement on high-resolution vessel imaging (HR-VWI) is a marker inflammation and instability. We aim determine if there any association between increased contrast in aneurysmal its parent artery.
Myotonic dystrophy type 1 is the most common form of muscular in adults, and primarily characterized by muscle weakness myotonia, yet some disabling symptoms disease are cognitive behavioral. Here we evaluated several these non-motor from a cross-sectional time-point one largest longitudinal studies to date, including full-scale intelligence quotient, depression, anxiety, apathy, sleep, cerebral white matter fractional anisotropy group 39 adult-onset myotonic participants (27 female)...
We tested the hypothesis that variant repeat interruptions (RIs) within DMPK CTG tract lead to milder symptoms compared with pure repeats (PRs) in myotonic dystrophy type 1 (DM1).We evaluated motor, neurocognitive, and behavioral outcomes a group of 6 participants DM1 RI case-matched sample 12 PR unaffected healthy comparison (UA).In every measure, were intermediate between UA participants. For muscle strength, was significantly less impaired than group. measures Full Scale IQ, depression,...
Abstract Background Juvenile‐onset Huntington's disease (JOHD) is a rare form of (HD) characterized by symptom onset before the age 21 years. Observational data in this cohort lacking. Objectives Quantify measures progression for use clinical trials patients with JOHD. Methods Participants who received motor diagnosis HD were included Kids‐JOHD study. The comparator group consisted children and young adults at‐risk inheriting genetic mutation that causes HD, but found to have CAG repeat...
Spinocerebellar ataxia type 1 is a progressive neurodegenerative, movement disorder. With potential therapies on the horizon, it critical to identify biomarkers that (i) differentiate between unaffected and spinocerebellar Type 1-affected individuals; (ii) track disease progression; (iii) are directly related clinical changes of patient. Magnetic resonance imaging volumetric in brain may be suitable source for 1. In previous report longitudinal study patients with 1, we evaluated volume...
Social isolation is common among individuals with isolated cleft lip and palate (ICLP), but the available data on why this may be are mixed. We present a novel theory relating to reduced social motivation in ICLP, called abulia hypothesis. Based hypothesis, we predicted that would lead responsiveness negative feedback, terms of both explicit responses noncontrolled, psychophysiological responses. Twenty males ICLP 20 normal comparison between 13 25 years old participated study. was examined...