A5003055382- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Acute Ischemic Stroke Management
- Moyamoya disease diagnosis and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Imaging and Diagnostics
- Meningioma and schwannoma management
- Cardiovascular Health and Disease Prevention
- Healthcare professionals’ stress and burnout
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Retinal and Optic Conditions
- S100 Proteins and Annexins
- Cerebrospinal fluid and hydrocephalus
- Aortic Disease and Treatment Approaches
- Immune cells in cancer
- Ocular Infections and Treatments
- Innovations in Medical Education
- Ocular Diseases and Behçet’s Syndrome
- MRI in cancer diagnosis
- Pituitary Gland Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
University of Iowa
2021-2024
University of Iowa Hospitals and Clinics
2020-2023
County Hospital
1993
Background Intracranial fusiform aneurysms are complex and poorly characterized vascular lesions. High-resolution magnetic resonance imaging (HR-MRI) computational morphological analysis may be used to characterize cerebral aneurysms. Objective To use advanced understand the unique pathophysiology, determine possible underlying mechanisms of instability Methods Patients with unruptured intracranial prospectively underwent 3T HR-MRI at diagnosis. Aneurysmal wall enhancement was objectively...
Abstract Aneurysm wall enhancement (AWE) after the administration of contrast gadolinium is a potential biomarker unstable intracranial aneurysms. While most studies determine AWE subjectively, this study comprehensively quantified in 3D imaging using semi-automated method. Thirty patients with 33 unruptured aneurysms prospectively underwent high-resolution 7T-MRI. The signal intensity (SI) aneurysm was mapped and normalized to pituitary stalk (PS) corpus callosum (CC). CC proved be more...
Background Anterior cranial fossa dural arteriovenous fistulas (ACF-dAVFs) are aggressive vascular lesions. The pattern of venous drainage is the most important determinant symptoms. Due to absence a sinus in anterior fossa, ACF-dAVFs have some degree through small cortical veins. We describe natural history, angiographic presentation and outcomes largest cohort ACF-dAVFs. Methods CONDOR consortium includes data from 12 international centers. Patients included study were diagnosed with an...
Background Aneurysm wall enhancement (AWE) is a potential surrogate biomarker for aneurysm instability. Previous studies have assessed AWE using 2D multiplanar methods, most of which were conducted qualitatively. Objective To use new quantitative tool to analyze large cohort saccular aneurysms with 3D-AWE maps Methods Saccular imaged prospectively 3T high resolution MRI. symptomatic (defined as ruptured or presentation sentinel headache/cranial nerve neuropathy) and asymptomatic created by...
Background Aneurysm wall enhancement is a potential imaging biomarker for risk stratification of intracranial aneurysms (IAs). Variations in the texture magnetic resonance (MRI) signal could shed light on underlying pathobiology aneurysm wall. Radiomics can help quantify textural complexity MRI images, which lead to better understanding and IAs. Herein, we investigated use radiomics derived from nonenhanced contrast‐enhanced identify high‐risk IAs evaluated their performance different data...
<h3>BACKGROUND AND PURPOSE:</h3> High-resolution MR imaging allows the identification of culprit symptomatic plaques after administration gadolinium. Current high-resolution methods are limited by 2D multiplanar views and manual sampling ROIs. We analyzed a new 3D method to objectively quantify gadolinium plaque enhancement. <h3>MATERIALS METHODS:</h3> Patients with stroke due intracranial atherosclerotic disease underwent 7T imaging. segmentations its parent vessel were generated. Signal...
Aneurysm wall enhancement has been identified as a potential biomarker for aneurysm instability. Enhancement determined by different approaches on 2D multiplanar views. This study describes new method to quantify through 3D heatmaps and histograms.A custom algorithm was developed using orthogonal probes extending from the lumen into create histograms of 7T-MRI. Three quantitative metrics general, specific, focal were generated histograms.Thirty-two aneurysms analyzed classified based...
High-resolution magnetic resonance imaging has the potential of characterising arterial wall changes after endovascular mechanical thrombectomy. The purpose this study is to evaluate high-resolution features large intracranial arteries following thrombectomy.Patients who presented with acute ischaemic stroke due vessel occlusion and underwent thrombectomy were prospectively recruited. Subjects within 24 hours procedure. Magnetic sequences included whole brain T1 pre post-contrast black-blood...
Background Current imaging modalities underestimate the severity of intracranial atherosclerotic disease (ICAD). High resolution vessel wall (HR-VWI) MRI is a powerful tool in characterizing plaques. We aim to show that HR-VWI more accurate at detecting and plaques compared digital subtraction angiography (DSA), time-of-flight (TOF) MRA, computed tomography angiogram (CTA). Methods Patients with symptomatic ICAD prospectively underwent 7T HR-VWI. calculated: degree stenosis, plaque burden...
Introduction Untreated brain aneurysms are usually surveilled with serial MR imaging and evaluated 2D multiplanar measurements. The assessment of aneurysm growth may be more accurate volumetric analysis. We the accuracy a magnetic resonance angiography (MRA) segmentation pipeline for volume measurement surveillance. Methods A to determine was developed tested on two phantoms imaged time-of flight (TOF) MRA 3D rotational (3DRA). then by reconstructing 10 contrast enhanced-MRA (CE-MRA) 3DRA....
Biomechanical computational simulation of intracranial aneurysms has become a promising method for predicting features instability leading to aneurysm growth and rupture. Hemodynamic analysis behavior helped investigate the complex relationship between shape, morphology, flow patterns, proliferation or degradation wall. Finite element paired with high-resolution vessel wall imaging can provide more insight into how exactly morphology relates behavior, whether enhancement describe this...
Background: Wall enhancement of unruptured intracranial aneurysms (UIAs) on high-resolution vessel wall imaging (HR-VWI) has been applied as a surrogate inflammation. MR-quantitative susceptibility mapping (QSM) can identify microbleeds (MBs) at the interface between aneurysm and brain tissue preceding subarachnoid hemorrhage.
ABSTRACT Background Restorative justice (RJ) is an ethical lens that places emphasis on a community's connection and proliferative impact of actions, promoting communication establishing methods for accountability. RJ practices can be applied spectrum, including proactive community‐building practices, community discussions in response to event, restorative conferences addressing specific incidences harm. This article describes intervention utilized within medical education environment...
The degree of internal carotid artery (ICA) stenosis determined by criteria from the North American Symptomatic Carotid Endarterectomy Trial (NASCET) is not most accurate index to assess distal flow compromise. Distal ICA perfusion also factors such as tandem and collateral circulation. Quantification end-organ ocular using non-invasive laser speckle flowgraphy (LSFG) may provide insights into flow. This study prospectively assessed LSFG.Eighteen patients with symptomatic underwent LSFG...
Introduction: Robust evidence suggest that aneurysmal subarachnoid hemorrhage (aSAH) triggers a potent respone from innate and adaptive inmunities. An increase in CD8+CD161+ cells has been observed the acute phase of patients with aSAH. However, role this is poorly understood. Methods: Cerebrospinal fluid aSAH non-aneurysmal SAH (nasSAH) was analyzed. Single cell RNA sequencing (scRNAseq) sorted CSF performed. Specific populations were identified based on gene clustering. Additionaly ten...
Introduction The severity of internal carotid artery (ICA) atherosclerosis is assessed through measurements degree stenosis. This approach does not factor in mechanisms compensating for reduced distal perfusion, such as collateral circulation. An alternative evaluating stenosis based on downstream changes ocular perfusion. Laser speckle flowgraphy (LSFG) a non‐invasive tool that quantifies intraocular blood flow. pilot study investigated whether LSFG metrics could be surrogates Additionally,...
Background: The study of plaque enhancement using high resolution vessel wall imaging can provide useful prognostic data. However, this analysis is hindered by sampling and methodological constrains. We developed a new method to quantify with 3D map analysis. Methods: Ultra-high (7 Tesla) was performed on 41 patients history symptomatic atherosclerotic disease. Culprit non-culprit plaques were analyzed. reconstructions culprit (N=41) (N=14) T1 T1+Gd images. Using an in-house code, orthogonal...
dentification of the neck unruptured intracranial aneurysms is essential for quantitative analysis and monitoring disease progression. Given a limited number available tools detection measurements, physicians have little choices when it comes to producing clinically accurate metrics. This research presents novel method aneurysm based on semi-automated segmentation its associated vessels. The reported utilizes LOGISMOS-JEI1 as foundation form global-optimality-guaranteeing strategy morphology.
<h3>Introduction/Purpose</h3> Computational fluid dynamic (CFD) and finite element (FEA) simulations can provide insight into the unique physical environment that precedes aneurysm rupture. Areas subject to decreased mechanical stresses may rupture because of inflammatory changes in wall. Topographic analysis wall enhancement (AWE), shear stress, tension three dimensions identify aneurysmal compartments more susceptible <h3>Materials Methods</h3> Unruptured aneurysms were prospectively...
This meeting abstract was removed due to the OA licensing requirements of this journal. The full is listed here : https://www.svin.org/files/SVIN_2021_Abstracts_for_Web.pdf