A5042326558- Intracranial Aneurysms: Treatment and Complications
- Pelvic floor disorders treatments
- Vascular Malformations Diagnosis and Treatment
- Maternal and Perinatal Health Interventions
- Emergency and Acute Care Studies
- Blood Pressure and Hypertension Studies
- Traffic and Road Safety
- Neurological disorders and treatments
- Bipolar Disorder and Treatment
- COVID-19 and healthcare impacts
- Diverticular Disease and Complications
- Venous Thromboembolism Diagnosis and Management
- Cerebrospinal fluid and hydrocephalus
- COVID-19 Clinical Research Studies
- Cerebral Venous Sinus Thrombosis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood groups and transfusion
- Hemophilia Treatment and Research
- Fetal and Pediatric Neurological Disorders
- Clinical Reasoning and Diagnostic Skills
- Neonatal and fetal brain pathology
- Innovations in Medical Education
- Anorectal Disease Treatments and Outcomes
- Cardiovascular Disease and Adiposity
- Kawasaki Disease and Coronary Complications
University of Iowa Hospitals and Clinics
2022-2025
University of Iowa
2021-2025
Louisiana State University Health Sciences Center Shreveport
2024
Louisiana State University
2024
Boston Children's Hospital
2024
Harvard University
2024
University of Iowa Health Care
2024
Universidad Internacional del Ecuador
2024
Universidad San Francisco de Quito
2024
Division of Chemistry
2023
Abstract Determine the prevalence of pelvic floor disorders (PFD) stratified by age, race, body mass index (BMI), and parity in adult women attending family medicine general internal clinics at an academic health system. The medical records 25,425 primary care were queried using International Classification Diseases-10th Revision codes (ICD-10 codes) for PFD [urinary incontinence (UI), organ prolapse (POP), bowel dysfunction (anal (AI) difficult defecation)]. Prevalence odds ratios...
Neutrophils, particularly low-density neutrophils (LDNs), are believed to contribute acute COVID-19 severity. Here, we showed that neutrophilia can be detected acutely and even months after SARS-CoV-2 infection in patients mice, while neutrophil depletion reduced disease severity mice. A key factor severe infected mice was traced the chemokine CXCL12 secreted by bone marrow cells unexpectedly, endothelial cells. levels were negatively correlated with LDN numbers longitudinal analyses of...
BackgroundIntracranial hemorrhage (ICH) is a complication of oral anticoagulation and associated with significant morbidity mortality. Clinical need exists for biomarkers to measure in patients factor Xa inhibitor-associated ICH assess the hemostatic effect reversal agents. This study explored utility thromboelastography (TEG) emergency department (ED) who received activated prothrombin complex concentrate (aPCC) Xa-inhibitor-associated ICH.MethodsThis was prospective, single-center, cohort...
A high body mass index (BMI) is a risk factor for obstructive sleep apnea. However, to our knowledge there no reported equation that quantifies the relationship between weight, as measured by BMI, and apnea severity, assessed apnea-hypopnea (AHI). Our objective was find mathematical BMI AHI.We prospectively recruited 434 veterans from polysomnography laboratory. Veterans already undergoing study were approached, those who consented enrolled. The enrolled in also participated their scheduled...
The Pelvic Organ Prolapse Quantification (POP-Q) stages do not correlate with symptoms or characterize important prolapse subtypes. We hypothesize that clinically meaningful "phenotypes" utilizing POP-Q measurements can be defined. primary aim was to define the phenotypes and their frequency. Secondary aims were compare demographics, medical characteristics, between phenotypes. Patients who previously underwent surgery retrospectively categorized into 1 of 8 based on 2 principles: (1) exists...
The impact of respiratory exacerbation on chronic obstructive pulmonary disease (COPD) is well established. effects exacerbations in people with cigarette smoking but normal spirometry are unknown. To assess the association lung function decline and mortality current or former history. We analyzed data from COPDGene participants ≥10 pack-years at enrollment (Visit 1) defined as post-bronchodilator forced expiratory volume 1 second (FEV1)/forced vital capacity (FVC) ≥lower limit (LLN) FEV1...
The ability to perform flexible ureteroscopy in children may be limited due a smaller pediatric ureterovesical junction and ureteral diameter. Tamsulosin has been shown improve success rates of instrumentation adults. To date, the efficacy this medication facilitate access remains unclear. We conducted multi-institutional retrospective review patients aged 0-17 years who underwent for treatment nephrolithiasis from 2013 2022. Patients were excluded if they had undergone or stent placement...
Evidence shows the 2014 American Urologic Association Cryptorchidism Guidelines have not influenced use of ultrasonography prior to urologic evaluation or referral timing. We evaluated whether local indicators healthcare access are associated with these quality-of-care indicators. Boys referred in 2013, 2015, and 2019 for cryptorchidism at four institutions were retrospectively analyzed. Local assessed by cross-referencing patient zip codes Rural Health Information Resources Service...
ABSTRACT Objective Human papillomavirus (HPV) vaccination prevents HPV infections and associated diseases, such as cervical cancer. is particularly important in areas with high HIV prevalence, women living have increased risk of developing cancer from infection. Understanding reasons why patients are not vaccinated may help increase uptake the vaccine. Methods A survey was administered to girls 10–18 years old their caretakers an clinic Kampala, Uganda. The consisted questions regarding...
OBJECTIVE Increased contrast enhancement of the aneurysm wall may indicate instability. The authors tested different predictive models instability on a cohort patients imaged with high-resolution magnetic resonance imaging (HR-MRI). METHODS Patients intracranial aneurysms were prospectively scanned HR-MRI. Aneurysm was defined as rupture or symptomatic status at presentation. Magnetic images analyzed, and 3D maps generated to analyze enhancement. Additionally, radiomics features extracted...
Effective interventions to prevent diagnostic error among critically ill children should be informed by prevalence and etiologies. We aimed determine the characteristics of errors identify factors associated with in patients admitted PICU.
Background Rates of nephrotoxic AKI are not well described in adults due to lack a clear definition, debate over which drugs should be considered nephrotoxins, and illness-related confounding. Nephrotoxic Injury Negated by Just-in Time Action (NINJA), program that reduces rates pediatric populations, may able address these concerns, but whether NINJA can effectively applied remains unclear. Methods In this retrospective cohort study conducted at the University Iowa Hospital, we included...
Advancing age increases cardiovascular disease risk, in part, because of impaired glycocalyx thickness and endothelial dysfunction. Glycocalyx-targeted therapies, such as Endocalyx Pro, could improve both function older adults; however, this has yet to be tested. We hypothesized that Pro supplementation would increase adults. Twenty-three adults aged 66 ± 7 yr (52% female) were enrolled a randomized, double-blind, placebo-controlled, parallel-arms study investigate the effect 12-wk (3,712...
The long-term outcome of infantile hydrocephalus (IH) in children born at term during a period active shunt treatment was studied population-based survey. series consisted 68 greater than or equal to 6 years old and 1967-78 the south-western Swedish health care region. clinical follow-up included neuro-paediatric assessment, Stott's test motor impairment, WISC test, CT EEG analyses. Nineteen (28%) had cerebral palsy, 17 (25%) minor dysfunction 32 (47%) no dysfunction; mental retardation...
Four patients of two families with clinical characteristics resembling those in Marinesco-Sjögren syndrome are presented. All had infantile hypotonia as the presenting sign. In preschool age ataxia, cataract and mental retardation manifested. CT scan revealed cerebellar atrophy. Muscle biopsy showed myopathic changes vacuolar degeneration marked adipose tissue proliferation. Electron microscopy myelin bodies autophagic vacuoles.The conclusion is that peculiar degenerative findings muscle a...
Background Anterior cranial fossa dural arteriovenous fistulas (ACF-dAVFs) are aggressive vascular lesions. The pattern of venous drainage is the most important determinant symptoms. Due to absence a sinus in anterior fossa, ACF-dAVFs have some degree through small cortical veins. We describe natural history, angiographic presentation and outcomes largest cohort ACF-dAVFs. Methods CONDOR consortium includes data from 12 international centers. Patients included study were diagnosed with an...
Background Aneurysm wall enhancement (AWE) is a potential surrogate biomarker for aneurysm instability. Previous studies have assessed AWE using 2D multiplanar methods, most of which were conducted qualitatively. Objective To use new quantitative tool to analyze large cohort saccular aneurysms with 3D-AWE maps Methods Saccular imaged prospectively 3T high resolution MRI. symptomatic (defined as ruptured or presentation sentinel headache/cranial nerve neuropathy) and asymptomatic created by...
Limited data exist about effective regimens for pharmacological thromboprophylaxis in children with acute coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome (MIS-C).