A5107500428- Genetic Neurodegenerative Diseases
- Hereditary Neurological Disorders
- Antibiotic Resistance in Bacteria
- Peripheral Neuropathies and Disorders
- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- Innovations in Medical Education
- Myasthenia Gravis and Thymoma
- Acute Ischemic Stroke Management
- Diversity and Career in Medicine
- Parkinson's Disease Mechanisms and Treatments
- Neurology and Historical Studies
- Botulinum Toxin and Related Neurological Disorders
- Peripheral Nerve Disorders
- Health and Medical Research Impacts
- Muscle activation and electromyography studies
- Antimicrobial Resistance in Staphylococcus
- Neurogenetic and Muscular Disorders Research
- Neurological diseases and metabolism
- Autoimmune Neurological Disorders and Treatments
- Stroke Rehabilitation and Recovery
- Amyotrophic Lateral Sclerosis Research
- Glycogen Storage Diseases and Myoclonus
- Health Systems, Economic Evaluations, Quality of Life
- Antibiotics Pharmacokinetics and Efficacy
Indiana University – Purdue University Indianapolis
2009-2024
Mayo Clinic
2008-2024
University of Iowa
2014-2024
University of Michigan
2011-2024
University of Virginia
1991-2024
Indiana University School of Medicine
2009-2024
Providence Health & Services
2024
Health and Education Research Management and Epidemiologic Services (United States)
2023
Jeroen Bosch Ziekenhuis
2023
University of Iowa Hospitals and Clinics
2016-2022
To identify risk factors for and prognostic indicators of the nosocomial acquisition multiresistant Acinetobacter baumannii in an intensive care unit, we prospectively studied 40 patients: 13 who were infected with this organism 27 colonized. Isolates identified by pulsed-field gel electrophoresis; infected/colonized patients compared 348 noninfected, noncolonized logistic regression analysis matched historical controls a cohort study. The severity illness (evaluated APACHE II score; P <...
<b>Background: </b> Previous human clinical trials of insulin-like growth factor type I (IGF-1) in amyotrophic lateral sclerosis (ALS) have been inconsistent. This phase III, randomized, double-blind, placebo-controlled study was undertaken to address whether IGF-1 benefited patients with ALS. <b>Methods: A total 330 from 20 medical centers were randomized receive 0.05 mg/kg body weight recombinant given subcutaneously twice daily or placebo for 2 years. The primary outcome measure change...
Objective Immune dysregulation influences outcome following acute ischemic stroke (AIS). Admission white blood cell (WBC) counts are routinely obtained, making the neutrophil–lymphocyte ratio (NLR) a readily available biomarker of immune response to stroke. This study sought identify relationship between NLR and 90 day AIS outcome. Methods A retrospective analysis was performed on patients who underwent endovascular therapy for at West Virginia University Hospitals, Morgantown, Virginia. WBC...
We sought to determine whether acute resistance exercise (RE)-induced gene expression is modified by RE training. studied the patterns of a select group genes following an bout in naïve and hypertrophying muscle. Thirteen untrained subjects underwent supervised training for 12 wk nondominant arm performed 1 after last program ( training+acute). The dominant was either unexercised control) or subjected same as trained RE). Following training, men (14.8 ± 2.8%; P < 0.05) women (12.6 2.4%;...
In a previous study, 0.3 and 0.45 mg/kg of intravenous recombinant tissue plasminogen activator (rt-PA) were safe when combined with eptifibatide 75 mcg/kg bolus 2-hour infusion (0.75 per minute). The Combined Approach to Lysis Utilizing Eptifibatide rt-PA in Acute Ischemic Stroke-Enhanced Regimen (CLEAR-ER) trial sought determine the safety higher-dose regimen establish evidence for phase III trial.CLEAR-ER was multicenter, double-blind, randomized study. stroke patients 0.6 plus (135 at...
Background: The American Academy of Neurology (AAN) ALS Practice Parameter was published in April 1999. CARE Database has been collecting data on the management patients with North America since 1996. Objective: To compare as recorded recommendations AAN Parameter. Methods: Data were analyzed from 2018 at enrollment and 373 these who died between May Results: Eighty-two percent enrolled reported that they had given enough information about ALS. Only 54% drooling receiving medication for this...
Abstract Background The molecular mechanisms underlying the sex differences in human muscle morphology and function remain to be elucidated. skeletal transcriptome both resting state following anabolic stimuli, such as resistance exercise (RE), might provide insight contributors of sexual dimorphism phenotypes. We used microarrays profile biceps brachii young men women who underwent an acute unilateral RE session 12 weeks progressive training. Bilateral biopsies were obtained either at early...
The primary aim of this investigation was to evaluate the effect training on immune activation in skeletal muscle response an acute bout resistance exercise (RE). Seven young healthy men and women underwent a 12-wk supervised progressive unilateral arm RE program. One week after last session, subjects performed bilateral which trained untrained exercised at same relative intensity. Muscle biopsies were obtained 4 h postexercise from biceps brachii both arms assessed for global transcriptom...
To develop a global view of muscle transcriptional differences between older men and women sex-specific aging, we obtained biopsies from the biceps brachii young profiled whole-genome gene expression using microarray. A logistic regression-based method in combination with an intensity-based Bayesian moderated t test was used to identify significant sex- aging-related functional groups. Our analysis revealed extensive sex transcriptome individuals different patterns changes aging women. In...
<h3>Objective</h3> To evaluate the sensitivity of Rasch analysis-based, weighted Charcot-Marie-Tooth Neuropathy and Examination Scores (CMTNS-R CMTES-R) to clinical progression in patients with disease type 1A (CMT1A). <h3>Methods</h3> Patients CMT1A from 18 sites Inherited Neuropathies Consortium were evaluated between 2009 2018. Weighted CMTNS CMTES modified category responses developed analysis standard scores. Change baseline for CMTNS-R CMTES-R was estimated longitudinal regression...
Two patients with acute onset of profound weakness and loss muscle bulk during a critical illness had unusual histopathological changes type II myofibers. Both respiratory failure prolonged neuromuscular blockade. High-dose steroids were used in only one case atracurium the other. Muscle biopsies at days 30 to 32 demonstrated widespread atrophy, basophilic cytoplasm, vesicular nuclei, features suggestive regeneration involving virtually all myofibers sparing I This may be another variant or...
We have previously described a clinical isolate of Escherichia coli (Q2) that is highly resistant to fluoroquinolones (MIC ciprofloxacin, 16 micrograms/ml) but susceptible nalidixic acid acid, 4 (N. Moniot-Ville, J. Guibert, N. Moreau, J.F. Acar, E. Collatz, and L. Gutmann, Antimicrob. Agents Chemother. 35:519-523, 1991). Transformation strain Q2 with plasmid carrying the wild-type gyrA gene from K-12(pAFF801) resulted in 32-fold decrease MIC suggesting at least one mutation was involved...
To identify factors associated with medical students becoming neurologists because, despite the increasing burden of neurologic disorders, there is a growing neurologist shortage.Deidentified data from Association American Medical Colleges Matriculating Student Questionnaire (MSQ) and Graduation (GQ) were obtained for graduation years 2013 to 2014 through 2016 2017. Logistic regression was used assess demographic characteristics responses training career-related questions in association...
Abstract Objective Development of biomarkers for Charcot‐Marie‐Tooth (CMT) disease is critical implementing effective clinical trials. The most common form CMT, type 1A, caused by a genomic duplication surrounding the PMP22 gene. A recent report (Neurology 2018;90:e518–3524) showed elevation neurofilament light (NfL) in plasma CMT1A patients, which correlated with severity. However, no plasma/serum biomarker has been identified that specific to Schwann cells, directly affected cells CMT1A....
The nucleotide sequence of the SHV-5 beta-lactamase gene, subcloned from a plasmid Klebsiella pneumoniae, was determined. amino acid changes thought to be responsible for extended substrate profile are Gly----Ser234 and Glu----Lys235. is identical SHV-4, except Leu----Arg201, which accounts difference in apparent pI two enzymes.