Increased numbers of S100A4 + cells are associated with poor prognosis in patients who have cancer. Although the metastatic capabilities cancer been examined, functional role stromal metastasis is largely unknown. To study contribution metastasis, we used transgenic mice that express viral thymidine kinase under control promoter to specifically ablate cells. Depletion significantly reduced colonization without affecting primary tumor growth. Multiple bone marrow transplantation studies...

A retrospective review.The purpose of this study was to determine the role in body habitus and weight distribution on developing a surgical site infection (SSI).SSI after lumbar spine surgery remains significant cause morbidity. The literature demonstrates an increased risk postoperative infections associated with obesity, diabetes, multilevel surgeries.A review performed consecutive cohort 298 adult patients who underwent fusion surgeries between 2006 2008 at Duke University Medical Center....

Surgical outcomes for intramedullary spinal cord tumors are affected by many variables including tumor histology and preoperative neurological function.To analyze the impact of on outcome in primary tumors.A retrospective review 102 consecutive patients with treated at a single institution between January 1998 March 2009.Ependymomas were most common 55 (53.9%), followed 21 astrocytomas (20.6%), 12 hemangioblastomas (11.8%), 14 miscellaneous (13.7%). Gross total resection was achieved 50...

BACKGROUND: Superior-level facet joint violation by pedicle screws may result in increased stress to the level above instrumentation and contribute adjacent segment disease. Previous studies have evaluated violations open or percutaneous screw cases, but there are no reports describing a direct institutional comparison. OBJECTIVE: To compare incidence of superior-level for vs evaluate patient surgical factors that affect this outcome. METHODS: We reviewed 279 consecutive patients who...

Surgical site infections increase the incidence of morbidity and mortality as well health-care expenses. The cost care increases threefold to fourfold a consequence surgical infection after spinal surgery. aim present study was determine role subcutaneous fat thickness in development following cervical spine fusion surgery.We performed retrospective review consecutive cohort 213 adult patients who underwent posterior between 2006 2008 at Duke University Medical Center. horizontal distance...

The Bhartiya Nyaya Sanhita 2023 represents a significant overhaul of India’s criminal justice framework, aiming to modernize and streamline legal processes. This paper examines the key features legislation, comparing it with prior laws such as Indian Penal Code (IPC) 1860 Criminal Procedure (CrPC) 1973. By analysing modifications in definitions, penalties, procedural safeguards, this study highlights progressive shift towards more victim-centric approach, enhanced fairness, integration...

There is significant debate in the literature regarding optimal management of patients with diagnosis a spinal epidural abscess (SEA). Although some have advocated conservative treatment intravenous antibiotics alone select patients, recent studies shown that treated without early surgery are more likely to poor outcomes.In this study, we review at tertiary medical center spontaneous SEA. A total 104 had an SEA over 10-year period. More than half these presented back pain and no objective...

Retrospective review of prospective collected data on 22 patients.To describe our initial clinical experience and outcomes with the extreme lateral interbody fusion (XLIF) approach for spinal diseases requiring access to thoracic cavity.Minimally invasive anterior approaches spine have traditionally consisted thoracoscopic mini-open thoracotomy techniques. We present employing XLIF technique treat diseases.Clinical, radiographic, operative, postoperative, functional were analyzed.A total...

Study Design. A retrospective cohort review. Objective. The aim of this study is to investigate whether preoperative malnutrition an independent risk factor for unplanned 30-day readmission after elective spine surgery. Summary Background Data. Thirty-day hospital rate being used as a proxy quality care. Accordingly, hospitals and health systems are investing considerable resources into the identification patients at designing interventions reduce readmissions. Methods. medical records 145...

Abstract Most applications of nanotechnology in cancer have focused on systemic delivery cytotoxic drugs. Systemic relies accumulation nanoparticles a target tissue through enhanced permeability leaky vasculature and retention effect poor lymphatic drainage to increase the therapeutic index. is limited, however, by toxicity difficulty crossing natural obstructions, like blood spine barrier. Magnetic drug targeting (MDT) new technique reach tumors central nervous system. Here, we describe...

Intrathecal drug delivery is an attractive option to circumvent the blood-brain barrier for pain management through its increased efficacy of relief, reduction in adverse side effects, and cost-effectiveness. Unfortunately, there are limited guidelines physicians choose infusion or pump settings administer therapeutic doses specific regions spine brain. Although empiric trialing intrathecal drugs critical determine sustained currently no inexpensive vitro method guide selection spinal...

Multiple myeloma is the most common primary tumor of spine and malignant bone. Although spinal classically a radiosensitive lesion, clinical or radiographic signs instability merit surgical intervention. The authors present epidemiology, indications, outcome data series consecutive cases involving 31 surgically treated patients with diagnoses multiple plasmacytoma (the largest such reported to date).Surgical was criterion for operative intervention in this patient cohort. Spinal Instability...

Due to its complicated legal status, the effects of cannabis on elective spine surgery patients have not been well studied. In this nationwide analysis, we find that abuse is associated with higher perioperative thromboembolism and neurologic complications, respiratory sepsis, length stay, hospital charges, rates unfavorable discharge disposition.Retrospective cohort analysis a administrative database. The aim study was analyze association between serious adverse events following surgery....

Convection-enhanced delivery (CED) permits site-specific therapeutic drug within interstitial spaces at increased dosages through circumvention of the blood-brain barrier. CED is currently limited by suboptimal methodologies for monitoring agents that would permit technical optimization and enhanced efficacy.To determine whether a readily available small-molecule MRI contrast agent, gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA), could effectively track distribution larger...

Intradural extramedullary (IDEM) neoplasms are uncommon lesions that can pose a challenge for resection. Numerous factors affect the resectability and ultimately outcome of these lesions. The authors report their 10-year institutional experience with resection IDEM neoplasms, focusing on effect location surgical outcomes.The performed retrospective review 96 consecutive patients who presented cervical and/or thoracic tumor was resected between February 2000 July 2009. All underwent MRI,...

OBJECTIVE Wound infections following spinal surgery for deformity place a high toll on patients, providers, and the health care system. The prophylactic application of intraoperative vancomycin powder has been shown to lower infection risk after thoracolumbar decompression fusion correction. purpose this study was assess microbiological patterns postoperative surgical site (SSIs) use in adult patients undergoing surgery. METHODS All cases involving who underwent reconstruction at Duke...

Study Design. Retrospective cohort review. Objective. The aim of this study is to investigate whether patient race an independent predictor unplanned 30-day hospital readmission after elective spine surgery. Summary Background Data. Racial disparities are known exist for many aspects surgical care. However, it unknown if in readmissions surgery, area that becoming a prime focus clinical leaders and policymakers. Methods. Records 600 patients undergoing surgery at major academic medical...

OBJECTIVE Depression is the most prevalent affective disorder in US, and patients with spinal deformity are at increased risk. Postoperative delirium has been associated inferior surgical outcomes, including morbidity mortality. The relationship between depression postoperative undergoing spine surgery relatively unknown. aim of this study was to determine if an independent risk factor for development decompression fusion deformity. METHODS medical records 923 adult (age ≥ 18 years) elective...