A5041974767- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Systemic Sclerosis and Related Diseases
- Parathyroid Disorders and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- TGF-β signaling in diseases
- Liver physiology and pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- Congenital heart defects research
- Oral and gingival health research
- Renal cell carcinoma treatment
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Digestive system and related health
- Genetic and Kidney Cyst Diseases
- Fibroblast Growth Factor Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Heart Failure Treatment and Management
- Electrolyte and hormonal disorders
- Organ Transplantation Techniques and Outcomes
University of Göttingen
2013-2024
Universitätsmedizin Göttingen
2015-2024
German Centre for Cardiovascular Research
2016-2023
Center for Rheumatology
2014-2022
Universitätsklinikum des Saarlandes
2016
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2016
Johannes Gutenberg University Mainz
2016
Centrum für Integrierte Onkologie
2016
Harvard University
2003-2015
Beth Israel Deaconess Medical Center
2003-2015
Activated fibroblasts are associated with many different tumors. Myofibroblasts, activated fibroblasts, and perivascular mesenchymal cells such as pericytes play a role in cancer progression. Many studies suggest that myofibroblasts facilitate tumor growth The source for other within the tumors is still debated. Although de novo activation of quiescent into alpha-smooth muscle actin (alpha SMA)-positive one likely source, epithelial to transition bone marrow recruitment also evolving...
In June 2017, a media frenzy ensued after Michelle Carter was convicted of involuntary manslaughter in the state Massachusetts for facilitating suicide Conrad Roy. The verdict stirred controversy and cast spotlight on facilitation suicide, i.e., person9s act(s) done with purpose helping another to die by suicide. One form facilitation, physician-assisted has been extensively debated existing literature. this article, we set out explore legal forensic ramifications non–physician-assisted...
Activated fibroblasts are key contributors to the fibrotic extracellular matrix accumulation during liver fibrosis. The origin of such is still debated, although several studies point stellate cells as principal source. role adult hepatocytes in yet undetermined. Here, we provide evidence that pro-fibrotic growth factor, TGF-beta1, induces mouse undergo phenotypic and functional changes typical epithelial mesenchymal transition (EMT). We perform lineage-tracing experiments using AlbCre....
Tumstatin and endostatin are two inhibitors of angiogenesis derived from precursor human collagen molecules known as α3 chain type IV α1 XVIII collagen, respectively. Although both these noncollagenous (NC1) domain fragments collagens, they only share a 14% amino acid homology. In the present study we evaluated functional receptors, mechanism action, intracellular signaling induced by collagen-derived inhibitors. Human tumstatin prevents via inhibition endothelial cell proliferation...
Increased numbers of S100A4 + cells are associated with poor prognosis in patients who have cancer. Although the metastatic capabilities cancer been examined, functional role stromal metastasis is largely unknown. To study contribution metastasis, we used transgenic mice that express viral thymidine kinase under control promoter to specifically ablate cells. Depletion significantly reduced colonization without affecting primary tumor growth. Multiple bone marrow transplantation studies...
Intestinal fibrosis is a major complication of Crohn disease (CD), but the precise mechanism by which it occurs incompletely understood. As result, specific therapies to halt or even reverse have not been explored. Here, we evaluated contribution epithelial mesenchymal transition (EMT) intestinal associated with mouse model CD and also human inflammatory bowel disease. Mice administered intrarectal 2,4,6-trinitrobenzene sulfonic acid (TNBS) develop inflammation that resembles both...
The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer progression remain to be fully understood. While altered glucose metabolism CAFs could fuel cells, how such metabolic reprogramming emerges and is sustained needs further investigation. Studying isolated from patients with benign tissues cancer, conjunction multiple animal models, we demonstrate that exhibit a shift toward lactate pyruvate production biosynthetic pathways cells. depletion or suppression...
Tubulointerstitial fibrosis is a hallmark feature of chronic renal injury. Specific therapies to control the progression toward end-stage failure are limited. Previous studies have demonstrated that expression endogenous bone morphogenic protein-7 (BMP-7) reduced in kidneys several inducible mouse models acute and disease administration exogenous recombinant human BMP-7 (rhBMP-7) has beneficial effect on kidney function. Here we report treatment with rhBMP-7 leads improved function,...
In the kidney, a unique plasticity exists between epithelial and mesenchymal cells. During kidney development, metanephric mesenchyme contributes to emerging epithelium of nephron via transition (MET). injured adult renal epithelia contribute generation fibroblasts epithelial-mesenchymal transition, facilitating fibrosis. Recombinant human bone morphogenic protein (BMP)-7, morphogen that is essential for conversion from condensing during enhances repair tubular structures in kidney. this...