A5081679095- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Kidney Disease and Diabetes
- Cancer Immunotherapy and Biomarkers
- Complement system in diseases
- Renal and related cancers
- Epigenetics and DNA Methylation
- Acute Kidney Injury Research
- COVID-19 Clinical Research Studies
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Sclerosis and Related Diseases
- TGF-β signaling in diseases
- Cancer, Hypoxia, and Metabolism
- Dialysis and Renal Disease Management
- Peripheral Neuropathies and Disorders
- Lymphatic System and Diseases
- Vascular Procedures and Complications
- Systemic Lupus Erythematosus Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Phagocytosis and Immune Regulation
- Drug-Induced Hepatotoxicity and Protection
- SARS-CoV-2 and COVID-19 Research
- Renal cell carcinoma treatment
- Central Venous Catheters and Hemodialysis
Universitätsmedizin Göttingen
2021-2024
University of Göttingen
2012-2023
Center for Rheumatology
2014-2018
Harvard University
2014
Beth Israel Deaconess Medical Center
2014
The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer progression remain to be fully understood. While altered glucose metabolism CAFs could fuel cells, how such metabolic reprogramming emerges and is sustained needs further investigation. Studying isolated from patients with benign tissues cancer, conjunction multiple animal models, we demonstrate that exhibit a shift toward lactate pyruvate production biosynthetic pathways cells. depletion or suppression...
Methylation of CpG island promoters is an epigenetic event that can effectively silence transcription over multiple cell generations. Hypermethylation the Rasal1 promoter contributes to activation fibroblasts and progression kidney fibrosis. Here, we explored whether such causative hypermethylation could be reversed through endogenous mechanisms reversal a constituent antifibrotic activity bone morphogenic protein 7 (BMP7). We show successful inhibition experimental fibrosis administration...
Progression of chronic kidney disease remains a principal problem in clinical nephrology and there is pressing need for novel therapeutics biomarkers. Aberrant promoter CpG island methylation subsequent transcriptional silencing specific genes have emerged as contributors to progression disease. Here, we report that the Ras-GTP suppressor RASAL1 contributes causally fibrosis identified circulating methylated DNA fragments peripheral blood correspond with levels intrarenal degree biopsies,...
Abstract Background In multiple sclerosis relapses refractory to intravenous corticosteroid therapy, plasma exchange is recommended. Immunoadsorption (IA) regarded as an alternative but its efficacy and putative mechanism of action still needs be established. Methods We prospectively treated 11 patients with who had optical neuritis fulfilled the indications for apheresis therapy (Trial registration DE/CA25/00007080-00). total, five IA treatments were performed using tryptophan-IA. Clinical...
As the coronavirus disease 2019 (COVID-19) pandemic is ongoing and new variants of severe acute respiratory syndrome type 2 (SARS-CoV-2) are emerging, there an urgent need for vaccines to protect individuals at high risk complications potentially control outbreaks by herd immunity. Surveillance rare safety issues related these progressing, since more granular data emerge about adverse events SARS-CoV-2 during post-marketing surveillance. Varicella zoster virus (VZV), Epstein-Barr (EBV)...
Acute kidney injury (AKI) is a common and severe complication of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) causing progressive chronic disease (CKD), end-stage renal (ESRD) or death. Pathogenic ANCAs, in particular proteinase 3 (PR3) myeloperoxidase (MPO), trigger deleterious immune response resulting pauci-immune necrotizing crescentic glomerulonephritis (GN), manifestation glomerular AAV. However, there growing evidence that activation the complement pathway...
Acute kidney injury (AKI) is a common and severe complication of anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), potentially leading to chronic disease (CKD), end-stage renal (ESRD), or death. Pathogenic ANCAs, in particular proteinase 3 (PR3) myeloperoxidase (MPO), trigger deleterious immune response with intrarenal cell infiltration resulting pauci-immune necrotizing crescentic glomerulonephritis (GN). However, systematic analysis subtypes concerning neutrophils,...
Context Due to recent advantages in cancer therapy, immune checkpoint inhibitors (ICIs) are new classes of drugs targeting programmed cell death protein 1 (PD-1) or its ligand 1-ligand (PD-L1) used many therapies. Acute interstitial nephritis (AIN) is a potential and deleterious immune-related adverse events (irAE) the kidney observed patients receiving ICIs most common biopsy-proven diagnosis who develop acute injury (AKI). Based on previous reports, AIN associated with tubular positivity...
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic vasculitis, most frequently presenting as microscopic polyangiitis (MPA) or granulomatosis with (GPA). Kidney involvement common and severe complication of ANCA AAV which observed in considerable subset patients, mainly affecting glomeruli. However, tubulointerstitial lesions have also been described glomerulonephritis (GN). Therefore, we aim to describe active chronic GN subtypes by systematic...
Progression of chronic kidney disease associated with progressive fibrosis and impaired tubular epithelial regeneration is still an unmet biomedical challenge because, once lesions have manifested, no effective therapies are available as yet for clinical use. Prompted by various studies across multiple organs demonstrating that preconditioning regimens to induce endogenous regenerative mechanisms protect from later incurring acute injuries, we here aimed gain insights into the molecular...
Background: Acute kidney injury (AKI) is very common in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease 2019 (COVID-19) and considered as a risk factor for COVID-19 severity. SARS-CoV-2 renal tropism has been observed patients, suggesting that direct viral of the kidneys may contribute to AKI. We examined 20 adult cases with confirmed infection requiring ICU supportive care single-center prospective observational study investigated whether urinary markers (SARS-CoV-2 N)...
Background: Renal involvement is a common and severe complication of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), potentially resulting in pauci-immune necrotizing crescentic ANCA glomerulonephritis (GN) with acute kidney injury (AKI), end-stage renal disease (ESRD) or death. There recent evidence that the degree proteinuria at diagnosis associated long-term outcome GN. Therefore, we here aimed to systematically describe association between clinicopathological...
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small vessel affecting multiple organ systems, including the kidney. Besides investigations focusing on renal outcomes, sex differences associated with distinct clinical and histopathological findings in ANCA glomerulonephritis (GN) have not been systematically investigated. Therefore, we here aimed to analyze patients AAV biopsy-proven GN. We provide comprehensive analysis of 53 kidney biopsies GN retrospectively...
Renal venous congestion due to backward heart failure leads disturbance of renal function in acute decompensated (ADHF). Whether decongestion strategies have an impact on is unknown. Objective was evaluate changes intrarenal hemodynamics using Doppler ultrasonography (IRD) patients with reduced ejection fraction (HFrEF) and ADHF undergoing recompensation.Prospective observational study left ventricular (LV-EF) ≤ 35% hospitalized ADHF. IRD measurement performed within the first 48 h...
Renal involvement is a common and severe complication of AAV as it can cause ESRD. Histopathological subgrouping ARRS are helpful to predict long-term ESRD in patients with AAV. Because subgroup critically ill present deterioration kidney function requiring RRT at admission, we here aimed evaluate histopathological findings predictive value Berden's for severity AKI requirement during the short-term clinical course intensive care treatment predictors renal recovery RRT. A 15/46 (32. 6%)...
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small vessel vasculitis, most frequently presenting as microscopic polyangiitis (MPA) or granulomatosis with (GPA). Acute tubular injury the presence of tubulitis was previously reported to be prognostic value in ANCA glomerulonephritis (GN). In particular, distinct lesions were associated deterioration kidney function at AAV disease onset, well renal resistance treatment, and higher risk progression...
Potassium para-aminobenzoate (POTABA) is used to treat Peyronie's disease by decreasing fibrosis and plaque size progression. Among potential side effects, drug-induced liver injury (DILI) attributed POTABA administration has been reported in a few cases inferred immune hypersensitivity. In the present case, we investigated clinical, biochemical, serological features as well searched for non-drug-related causes, applied updated Roussel Uclaf Causality Assessment Method (RUCAM) confirming...