A5070112001- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
- Renal Diseases and Glomerulopathies
- Cancer Immunotherapy and Biomarkers
- Angiogenesis and VEGF in Cancer
- TGF-β signaling in diseases
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Cell death mechanisms and regulation
- Protease and Inhibitor Mechanisms
- Birth, Development, and Health
- Advanced Glycation End Products research
- Pregnancy and preeclampsia studies
- NF-κB Signaling Pathways
- Metabolism, Diabetes, and Cancer
- Cancer Research and Treatments
- Fibroblast Growth Factor Research
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- Kruppel-like factors research
The University of Texas MD Anderson Cancer Center
2015-2025
Memorial Hospital
2025
Kyoto Prefectural University of Medicine
2025
Okayama University
1998-2024
Beth Israel Deaconess Medical Center
2011-2024
Harvard University
2008-2024
Nagoya University
2023
Rice University
2023
The University of Texas Health Science Center at Houston
2020
Waseda University
2019
In June 2017, a media frenzy ensued after Michelle Carter was convicted of involuntary manslaughter in the state Massachusetts for facilitating suicide Conrad Roy. The verdict stirred controversy and cast spotlight on facilitation suicide, i.e., person9s act(s) done with purpose helping another to die by suicide. One form facilitation, physician-assisted has been extensively debated existing literature. this article, we set out explore legal forensic ramifications non–physician-assisted...
Exosomes are extracellular vesicles produced by all cells with a remarkable ability to efficiently transfer genetic material, including exogenously loaded siRNA, cancer cells. Here, we report on bioreactor-based, large-scale production of clinical-grade exosomes employing good manufacturing practice (GMP) standards. A standard operating procedure was established generate engineered the target oncogenic Kras (iExosomes). The GMP iExosomes were tested in multiple vitro and vivo studies confirm...
Tumors are unorganized organs that contain many different cell types. In the recent years, studies have reported primary tumors fibroblasts/myofibroblasts (carcinoma-associated fibroblasts), mesenchymal cells such as pericytes/mural and other vascular smooth muscle cells. Several markers used routinely to identify carcinoma-associated fibroblasts (CAFs) alpha-smooth actin (alpha-SMA), vimentin, S100A4 protein/fibroblast specific protein-1 (FSP1) type I collagen. Likewise platelet derived...
Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. This explains why podocyte injury is typically associated with nephrotic syndrome. The present study uncovered an unanticipated novel role for costimulatory molecule B7-1 in as inducible modifier of glomerular permselectivity. was found genetic, drug-induced, immune-mediated, bacterial toxin–induced experimental kidney diseases clinical significance our results underscored by observation that...
There are about 2.5 million glomeruli in the kidneys each consisting of a barrel glomerular basement membrane surrounded by endothelial cells on inside and epithelial with established foot processes (podocytes) outside. Defects this filtration apparatus lead to vascular leak or proteinuria. The role growth factor (VEGF) regulation permeability is still unclear. Recent studies indicate that patients receiving anti-VEGF antibody therapy may have an increased incidence In different setting,...
Tumstatin and endostatin are two inhibitors of angiogenesis derived from precursor human collagen molecules known as α3 chain type IV α1 XVIII collagen, respectively. Although both these noncollagenous (NC1) domain fragments collagens, they only share a 14% amino acid homology. In the present study we evaluated functional receptors, mechanism action, intracellular signaling induced by collagen-derived inhibitors. Human tumstatin prevents via inhibition endothelial cell proliferation...
Increased numbers of S100A4 + cells are associated with poor prognosis in patients who have cancer. Although the metastatic capabilities cancer been examined, functional role stromal metastasis is largely unknown. To study contribution metastasis, we used transgenic mice that express viral thymidine kinase under control promoter to specifically ablate cells. Depletion significantly reduced colonization without affecting primary tumor growth. Multiple bone marrow transplantation studies...
Intestinal fibrosis is a major complication of Crohn disease (CD), but the precise mechanism by which it occurs incompletely understood. As result, specific therapies to halt or even reverse have not been explored. Here, we evaluated contribution epithelial mesenchymal transition (EMT) intestinal associated with mouse model CD and also human inflammatory bowel disease. Mice administered intrarectal 2,4,6-trinitrobenzene sulfonic acid (TNBS) develop inflammation that resembles both...
The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer progression remain to be fully understood. While altered glucose metabolism CAFs could fuel cells, how such metabolic reprogramming emerges and is sustained needs further investigation. Studying isolated from patients with benign tissues cancer, conjunction multiple animal models, we demonstrate that exhibit a shift toward lactate pyruvate production biosynthetic pathways cells. depletion or suppression...
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) involves a significant accumulation of fibroblasts as part the host response to cancer. Using single-cell RNA sequencing, multiplex immunostaining, and several genetic mouse models, we identify carcinoma-associated (CAF) with opposing functions PDAC progression. Depletion fibroblast activation protein (FAP)+ CAFs results increased survival, contrast depletion alpha smooth muscle actin (αSMA)+ CAFs, which leads decreased...