A5085893777- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Preterm Birth and Chorioamnionitis
- Birth, Development, and Health
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy-related medical research
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Cardiovascular Issues in Pregnancy
- Prenatal Screening and Diagnostics
- Pregnancy and Medication Impact
- Parvovirus B19 Infection Studies
- COVID-19 Impact on Reproduction
- Obstructive Sleep Apnea Research
- Cytomegalovirus and herpesvirus research
- Neonatal and Maternal Infections
- Oral microbiology and periodontitis research
- Congenital Heart Disease Studies
- Reproductive tract infections research
- Breastfeeding Practices and Influences
- Assisted Reproductive Technology and Twin Pregnancy
- Neuroscience of respiration and sleep
- Obesity, Physical Activity, Diet
University of Pennsylvania
2016-2025
Massachusetts General Hospital
2025
Harvard University
2025
University of Utah
2016-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2014-2024
Philadelphia University
1997-2024
University of Pennsylvania Health System
2008-2024
Office of the Director
2024
Duke University
2022-2024
University of North Carolina at Chapel Hill
2015-2024
Recent studies have suggested that bacteria associated with the placenta—a "placental microbiome"—may be important in reproductive health and disease. However, a challenge working specimens low bacterial biomass, such as placental samples, is some or all of DNA may derive from contamination dust commercial reagents. To investigate this, we compared samples healthy deliveries to matched set controls, well oral vaginal same women. We quantified total 16S rRNA gene copies using quantitative PCR...
To estimate whether sleep-disordered breathing during pregnancy is a risk factor for the development of hypertensive disorders and gestational diabetes mellitus (GDM).In this prospective cohort study, nulliparous women underwent in-home assessments in early (6-15 weeks gestation) midpregnancy (22-31 gestation). Participants health care providers were blinded to sleep test results. An apnea-hypopnea index 5 or greater was used define breathing. Exposure-response relationships examined,...
Historically, the human womb has been thought to be sterile in healthy pregnancies, but this idea challenged by recent studies using DNA sequence-based methods, which have suggested that is colonized with bacteria. For example, analysis of from placenta samples yielded small proportions microbial sequences were proposed represent normal bacterial colonization. However, an our group showed no distinction between background negative controls and samples. Also supporting observation germ-free...
It remains unknown whether SARS-CoV-2 infection specifically increases the risk of serious obstetric morbidity. To evaluate association with maternal morbidity or mortality from common complications. Retrospective cohort study 14 104 pregnant and postpartum patients delivered between March 1, 2020, December 31, 2020 (with final follow-up to February 11, 2021), at 17 US hospitals participating in Eunice Kennedy Shriver National Institute Child Health Human Development's Gestational Research...
OBJECTIVE: To assess the relationships between self-reported psychosocial stress and preterm birth, hypertensive disease of pregnancy, small-for-gestational-age (SGA) birth to extent which these account for racial ethnic disparities in adverse outcomes. METHODS: Self-reported measures (perceived stress, depression, racism, anxiety, resilience, social support) were collected during pregnancy among a racially ethnically diverse cohort women enrolled prospective observational study nulliparous...
During human pregnancy, the fetal circulation is separated from maternal blood in placenta by two cell layers - capillary endothelium and placental trophoblast. This barrier plays an essential role development health tightly regulating exchange of endogenous exogenous materials between mother fetus. Here we present a microengineered device that provides novel platform to mimic structural functional complexity this specialized tissue vitro. Our model created multilayered microfluidic system...
Primary cytomegalovirus (CMV) infection during pregnancy carries a risk of congenital and possible severe sequelae. There is no established intervention for preventing CMV infection.
Prophylactic use of tranexamic acid at the time cesarean delivery has been shown to decrease calculated blood loss, but effect on need for transfusions is unclear. Download a PDF Research Summary. We randomly assigned patients undergoing 31 U.S. hospitals receive either or placebo after umbilical-cord clamping. The primary outcome was composite maternal death transfusion by hospital discharge 7 days post partum, whichever came first. Key secondary outcomes were estimated intraoperative loss...
<h2>Abstract</h2> <b>Objective:</b> The rarer allele of a polymorphism within the promoter region at position –308 gene for tumor necrosis factor α is associated with increased transcription. In this study we tested hypothesis that spontaneous preterm birth. <b>Study Design:</b> We conducted case-control women admitted to our labor and delivery unit. To assess data from single racial group high incidence birth restricted analysis African American women, who contributed 73.6% samples...
We sought to determine if human papillomavirus (HPV) infection of extravillous trophoblast cells reduces cell invasion and placental is associated with adverse reproductive outcomes attributed dysfunction.We conducted apoptosis assays using (HTR-8/SVneo) that were transfected a plasmid (pAT-HPV-16) containing the entire HPV-16 genome. In order associate HPV outcomes, we case-control study detect DNA in region placentas from cases spontaneous preterm delivery, severe pre-eclampsia requiring...
<b>Objective</b> To test the hypothesis that a relative deficiency in L-arginine, substrate for synthesis of vasodilatory gas nitric oxide, may be associated with development pre-eclampsia population at high risk. <b>Design</b> Randomised, blinded, placebo controlled clinical trial. <b>Setting</b> Tertiary public hospital Mexico City. <b>Participants</b> Pregnant women history previous pregnancy complicated by pre-eclampsia, or first degree relative, and deemed to increased risk recurrence...
We sought to validate several clinical risk factors previously described for preeclampsia in a large contemporary multicenter prospective cohort.We enrolled women from three sites before 15 weeks of gestation. Demographic and were collected through standardized chart review. The main outcome was diagnosed using the American College Obstetricians Gynecologists definitions 2002. Multivariable logistic regression used control confounders.Two thousand six hundred thirty-seven are included this...
<h3>Importance</h3> Spontaneous preterm birth is a leading cause of infant mortality. Prediction, largely based on prior pregnancy outcomes, not possible in women pregnant for the first time. <h3>Objective</h3> To assess accuracy universal screening to predict spontaneous nulliparous using serial measurements vaginal fetal fibronectin levels and cervical length. <h3>Design, Settings, Participants</h3> A prospective observational cohort study with singleton pregnancies, from 8 clinical sites...
Significance Placental dysfunction has been causally linked to major pregnancy complications that are implicated in maternal–fetal morbidity and mortality, but the mechanisms underlying placental largely unknown. The recently identified ferroptotic cell death is characterized by excessive accumulation of hydroperoxide phosphatidylethanolamines. While oxidative damage commonly defines dysfunction, role ferroptosis this process We found preterm birth associated with signals, inhibition GPX4,...
OBJECTIVE: To characterize prescription and other medication use in a geographically ethnically diverse cohort of women their first pregnancy. METHODS: In prospective, longitudinal study nulliparous followed through pregnancy from the trimester, was chronicled longitudinally throughout Structured questions aids were used to capture all medications taken as well reasons they taken. Total counts including number each category class captured. Additionally, recorded. Trends across trimester...
To evaluate the effectiveness of four commonly used induction methods.