A5019560961- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Sleep and Wakefulness Research
- Gestational Diabetes Research and Management
- Maternal Mental Health During Pregnancy and Postpartum
- Birth, Development, and Health
- Sleep and Work-Related Fatigue
- Gastroesophageal reflux and treatments
- Neonatal and fetal brain pathology
- Menopause: Health Impacts and Treatments
- Tracheal and airway disorders
- Circadian rhythm and melatonin
- Restless Legs Syndrome Research
- Airway Management and Intubation Techniques
- Obesity, Physical Activity, Diet
- Cardiovascular Issues in Pregnancy
- Dysphagia Assessment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Pregnancy and preeclampsia studies
- Body Composition Measurement Techniques
- Cardiovascular and Diving-Related Complications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Phytoestrogen effects and research
- Diet and metabolism studies
University of Pennsylvania
2005-2025
National Heart Lung and Blood Institute
2024-2025
Johns Hopkins Medicine
2015-2024
Johns Hopkins University
2015-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2016-2024
Case Western Reserve University
2016-2019
Indiana University Bloomington
2016
Society for Maternal-Fetal Medicine
2016
Grace (United States)
2010
California Center for Sleep Disorders
2010
Although commonly observed in clinical practice, the heterogeneity of obstructive sleep apnoea (OSA) presentation has not been formally characterised. This study was first to apply cluster analysis identify subtypes patients with OSA who experience distinct combinations symptoms and comorbidities. An baseline data from Icelandic Sleep Apnoea Cohort (822 newly diagnosed moderate-to-severe OSA) performed. Three clusters were identified. They classified as "disturbed group" (cluster 1),...
In Brief OBJECTIVE: To test the hypothesis that prevalence of women with menopausal symptoms hot flushes; aches, joint pain, and stiffness; depressed mood; poor sleep; decreased libido; or vaginal dryness increases progression through transition. METHODS: Women in Penn Ovarian Aging Study were assessed longitudinally for 9 years. Data obtained from structured interviews, a validated symptom questionnaire, menstrual bleeding dates early follicular hormone measures (estradiol [E2],...
To estimate whether sleep-disordered breathing during pregnancy is a risk factor for the development of hypertensive disorders and gestational diabetes mellitus (GDM).In this prospective cohort study, nulliparous women underwent in-home assessments in early (6-15 weeks gestation) midpregnancy (22-31 gestation). Participants health care providers were blinded to sleep test results. An apnea-hypopnea index 5 or greater was used define breathing. Exposure-response relationships examined,...
Symptoms of sleep-disordered breathing (SDB) are common among pregnant women, and several studies link SDB symptoms with gestational hypertension preeclampsia. However, few prospective objectively measuring during pregnancy have been performed.We performed a cohort study examining risk factors for third trimester in women.105 women from the Hospital University Pennsylvania obstetrics practices completed first overnight polysomnography studies. We examined whether number events per hour sleep...
Although incident snoring is common in pregnant women and has been proposed as a potential risk factor for adverse maternalfetal outcomes, the development of sleep-disordered breathing during pregnancy not prospectively described. Using Apnea Symptom Score from Multivariable Prediction Index Epworth Sleepiness Scale, we assessed symptoms daytime somnolence 155 to determine whether increased characteristics associated with increasing symptoms. We found that (Apnea Score, 0.44 (SEM 0.58) vs...
Manual scoring of polysomnograms (PSG) is labor intensive and has considerable variance between scorers. Automation could reduce cost improve reproducibility. The purpose this study was to compare a new automated system (YST-Limited, Winnipeg, Canada) with computer-assisted manual scoring.
Explore the prevalence of sleep-related complaints across age groups, examining effects sex, general health, and depressed mood.Cross-sectional analysis data from 2006 Behavioral Risk Factor Surveillance System (BRFSS).Epidemiologic.Complete-case included 155,877 participants who responded to questions related Self-Reported Sleep Disturbance (SLEEPDIST) Tiredness/Lack Energy (TIREDNESS).None.Outcomes were self-reported in response survey assessing SLEEPDIST TIREDNESS, dichotomized as...
Distinct clinical phenotypes of obstructive sleep apnea (OSA) have been identified: Disturbed Sleep, Minimally Symptomatic, and Sleepy. Determining whether these respond differently to standard treatment helps us create a foundation for personalized therapies. We compared responses positive airway pressure (PAP) therapy in OSA phenotypes. The study sample included 706 patients from the Icelandic Sleep Apnea Cohort with moderate-to-severe who were prescribed PAP. Linear logistic mixed models...
Whether gender differences exist in clinical manifestations of obstructive sleep apnea (OSA) and whether women's responses to continuous positive airway pressure (CPAP) are similar those men critical areas exploration disordered breathing. This exploratory analysis addressed these questions by examining over a wide range outcomes at baseline response CPAP participants with severe OSA.Data from 152 24 women who participated multicenter effectiveness study were analyzed. Gender functional...
To determine intersite agreement in respiratory event scoring of polysomnograms (PSGs) using different hypopnea definitions.
This study aims to estimate the prevalence and predictors of moderate/severe poor sleep in relation final menstrual period (FMP) midlife women.
To characterize sleep duration, timing and continuity measures in pregnancy their association with key demographic variables. Multisite prospective cohort study. Women enrolled the nuMoM2b study (nulliparous women a singleton gestation) were recruited at second visit (16–21 weeks of to participate Sleep Duration Continuity substudy. <18 years age or pregestational diabetes chronic hypertension excluded from participation. wore wrist activity monitor completed log for 7 consecutive days. Time...
Manual scoring of polysomnograms is a time-consuming and tedious process. To expedite the polysomnograms, several computerized algorithms for automated have been developed. The overarching goal this study was to determine validity Somnolyzer system, an system polysomnograms. analysis sample comprised 97 sleep studies. Each polysomnogram manually scored by certified technologists from four laboratories concurrently subjected system. Agreement between manual examined. Sleep staging disordered...
<h3>Importance</h3> Hypertensive disorders of pregnancy are associated with future cardiovascular disease, perhaps because subclinical cardiac dysfunction before leading to impaired adaptation pregnancy. Natriuretic peptides promising biomarkers for detecting outside <h3>Objective</h3> To investigate whether higher concentrations N-terminal pro–brain natriuretic peptide (NT-proBNP) in early would be hypertensive and hypertension 2 7 years post partum. <h3>Design, Setting, Participants</h3>...