A5049632383- Sleep and Wakefulness Research
- Sleep and related disorders
- Circadian rhythm and melatonin
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- EEG and Brain-Computer Interfaces
- Youth Substance Use and School Attendance
- Restless Legs Syndrome Research
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- Sleep and Work-Related Fatigue
- Olfactory and Sensory Function Studies
- Regulation of Appetite and Obesity
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Health and Wellbeing Research
- Treatment of Major Depression
- Suicide and Self-Harm Studies
- Dietary Effects on Health
- Cognitive Abilities and Testing
- Obesity, Physical Activity, Diet
Wake Forest University
2016-2025
University of California, Irvine
2016-2024
University of Wisconsin–Madison
2014-2024
VA Palo Alto Health Care System
2024
Atrium Health Wake Forest Baptist
2022-2023
SleepMed
2019
Augusta University Health
2019
Medical University of South Carolina
2019
Geriatric Research Education and Clinical Center
2017
Alzheimer's Association
2017
OBJECTIVE: The anterior cingulate cortex has been implicated in depression. Results are best interpreted by considering anatomic and cytoarchitectonic subdivisions. Evidence suggests depression is characterized hypoactivity the dorsal cingulate, whereas hyperactivity rostral associated with good response to treatment. authors tested hypothesis that activity during depressed state prognostic value for degree of eventual Whereas prior studies used hemodynamic imaging, this investigation EEG....
Objectives. The primary purposes of the present study were to survey prevalence sleep problems in school-aged children and examine these associations with parental perception problems, medical history, childhood psychopathology. Methods. Sleep history questionnaires Child Behavior Checklist administered parents 472 between ages 4 12 years receiving routine pediatric care from urban, rural, suburban practices. Results. Although reported for 10.8% sample during past 6 months, less than one...
To test the utility of an integrated clinical pathway for obstructive sleep apnea (OSA) diagnosis and continuous positive airway pressure (CPAP) treatment using portable monitoring devices.Randomized, open-label, parallel group, unblinded, multicenter trial comparing home-based, unattended autotitrating CPAP (autoPAP) compared with in-laboratory polysomnography (PSG) titration.Seven American Academy Sleep Medicine (AASM) accredited centers.Consecutive new referrals, age 18 yr or older high...
Objective: Slow waves and sleep spindles are the two main oscillations occurring during non-REM sleep. While slow primarily generated modulated by cortex, initiated thalamic reticular nucleus regulated thalamo-reticular thalamo-cortical circuits. In a recent high-density EEG study, authors found that 18 medicated schizophrenia patients had reduced spindles, compared with healthy depressed subjects, first episode. present investigated whether spindle deficits were in larger sample of...
To determine the relationship between sleep quality and CSF markers of Alzheimer disease (AD) pathology in late midlife.We investigated AD biomarkers a cohort enriched for parental history sporadic AD, Wisconsin Registry Alzheimer's Prevention. A total 101 participants (mean age 62.9 ± 6.2 years, 65.3% female) completed assessments collection were cognitively normal. Sleep was measured with Medical Outcomes Study Scale. assayed amyloid metabolism plaques (β-amyloid 42 [Aβ42]), tau...
THE role of the amygdala in major depression was investigated. Resting regional cerebral metabolic rate (rCMRglu) measured with [18 F]fluorodeoxyglucose positron emission tomography (PET) two samples subjects using different PET cameras. The consisted 10 and 17 medication-free depressives 11 13 controls, respectively. Using coregistration magnetic resonance images, regions were individually delineated for thalamus, latter which used as a control region. Within depressed groups, right...
Twice a year, normally diurnal songbirds engage in long-distance nocturnal migrations between their wintering and breeding grounds. If how sleep during these periods of increased activity has remained mystery. We used combination electrophysiological recording neurobehavioral testing to characterize seasonal changes cognition captive white-crowned sparrows (Zonotrichia leucophrys gambelii) across nonmigratory migratory seasons. Compared state, spent approximately two-thirds less time...
Manual scoring of polysomnograms (PSG) is labor intensive and has considerable variance between scorers. Automation could reduce cost improve reproducibility. The purpose this study was to compare a new automated system (YST-Limited, Winnipeg, Canada) with computer-assisted manual scoring.
There are few established predictors of CPAP adherence; poor adherence limits its effectiveness. We investigated whether race, education level, and residential economic status predict in participants enrolled a trial with standard access to treatment. A multi-center randomized home vs. lab-based evaluation treatment OSA assessing at 1 3 months. Seven AASM-accredited sleep centers 5 U.S. cities. Subjects moderate severe (AHI ≥ 15 Epworth Sleepiness Scale score > 12) who completed follow-up...
To assess how the characteristics of slow waves and spindles change in falling-asleep process. Participants undergoing overnight high-density electroencephalographic recordings were awakened at 15- to 30-min intervals. One hundred forty-one periods analyzed scalp source level. Sleep laboratory. Six healthy participants. Serial awakenings. The number amplitude followed two dissociated, intersecting courses during transition sleep: wave increased slowly beginning rapidly end period, whereas...
The objective of the study was to determine if sleep disorder, depression or anxiety screening status associated with safety outcomes in a diverse population hospital workers. A sample shift workers at four hospitals participated prospective cohort study. Participants were screened for five disorders, and baseline, then completed monthly surveys next 6 months capture motor vehicle crashes, near-miss occupational exposures medical errors. We tested associations between adverse using incidence...
The authors sought to determine whether targeted treatment of insomnia with controlled-release zolpidem (zolpidem-CR) in suicidal adults would provide a reduction ideation superior placebo.Reducing Suicidal Ideation Through Insomnia Treatment was an 8-week three-site double-blind placebo-controlled parallel-group randomized controlled trial zolpidem-CR hypnotic therapy compared placebo, conjunction open-label selective serotonin reuptake inhibitor. Participants were medication-free 18-...