A5030345231- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Visual perception and processing mechanisms
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Protein Structure and Dynamics
- Face Recognition and Perception
- Memory Processes and Influences
- Advanced MRI Techniques and Applications
- Advanced Data Storage Technologies
- Radiology practices and education
- Innovations in Medical Education
- Alzheimer's disease research and treatments
- Advanced Memory and Neural Computing
- Neurological disorders and treatments
- Clinical Reasoning and Diagnostic Skills
- Neuroscience and Neuropharmacology Research
- Microbial Metabolic Engineering and Bioproduction
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neural Engineering
- Prion Diseases and Protein Misfolding
- Enzyme Structure and Function
University of Pennsylvania
2023-2024
University of Wisconsin–Madison
2012-2024
California University of Pennsylvania
2023-2024
Southern Illinois University Carbondale
2024
Hospital of the University of Pennsylvania
2023
NYU Langone Health
2022
New York University
2020-2022
Indiana University School of Medicine
2005
University of North Carolina at Chapel Hill
2005
The ability to hold information in working memory is fundamental for cognition. Contrary the long-standing view that depends on sustained, elevated activity, we present evidence suggesting humans can via "activity-silent" synaptic mechanisms. Using multivariate pattern analyses decode brain activity patterns, found active representation of an item drops baseline when attention shifts away. A targeted pulse transcranial magnetic stimulation produced a brief reemergence concurrently measured...
Traditionally, load sensitivity of sustained, elevated activity has been taken as an index storage for a limited number items in visual short-term memory (VSTM). Recently, studies have demonstrated that the contents single item held VSTM can be decoded from early cortex, despite fact these areas do not exhibit elevated, sustained activity. It is unknown, however, whether patterns neural sensory cortex change function load, one would expect region storing multiple representations. Here, we...
For decades it has been assumed that sustained, elevated neural activity--the so-called active trace--is the correlate of short-term retention information. However, a recent fMRI study suggested this activity may be more related to attention than retention. Specifically, multivariate pattern analysis failed find evidence information was outside focus attention, but nonetheless in STM, retained an state. Here, we replicate and extend finding by querying signatures attended versus unattended...
To assess how the characteristics of slow waves and spindles change in falling-asleep process. Participants undergoing overnight high-density electroencephalographic recordings were awakened at 15- to 30-min intervals. One hundred forty-one periods analyzed scalp source level. Sleep laboratory. Six healthy participants. Serial awakenings. The number amplitude followed two dissociated, intersecting courses during transition sleep: wave increased slowly beginning rapidly end period, whereas...
Dreaming - a particular form of consciousness that occurs during sleep undergoes major changes in the course night. We aimed to outline state-dependent features using paradigm with multiple serial awakenings/questionings allowed for within as well between subject comparisons. Seven healthy participants who spent 44 experimental study nights laboratory were awakened by computerized sound at 15-30 minute intervals, regardless stage, and questioned presence or absence consciousness. Recall...
Visual awareness is hypothesized to be intimately related visual working memory (WM), such that information present in WM thought have necessarily been represented consciously. Recent work has challenged this longstanding view by demonstrating stimuli rated observers as unseen can nevertheless maintained over a delay period. These experiments criticized, however, on the basis subjective ratings may contain response bias (e.g., an observer report no when fact they had partial awareness). We...
A long-standing assumption of cognitive neuroscience has been that working memory (WM) is accomplished by sustained, elevated neural activity. More recently, theories WM have expanded this view describing different attentional states in with differing activation levels. Several studies used multivariate pattern analysis (MVPA) functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) data to study activity corresponding these states. Intriguingly, no evidence was found...
Although the manipulation of load is popular in visual working memory research, many studies confound general attentional demands with context binding by drawing memoranda from same stimulus category. In this fMRI study human observers (both sexes), we created high- versus low-binding conditions, while holding constant, comparing trials requiring for direction motion one random dot kinematogram (RDK; 1M trials) three RDKs (3M), or RDK and two color patches (1M2C). Memory precision was...
Approximately 30% of critically ill patients have seizures, and more than half these seizures do not an overt clinical correlate. EEG is needed to avoid missing prevent overtreatment with antiseizure medications. Conventional-EEG (cEEG) resources are logistically constrained unable meet their growing demand for seizure detection even in highly developed centers. Brief screening the validated 2HELPS2B algorithm was proposed as a method triage cEEG resources, but it hampered by requirements,...
Protein conformational transition from alpha-helices to beta-sheets precedes aggregation of proteins implicated in many diseases, including Alzheimer and prion diseases. Direct characterization such transitions is often hindered by the complicated nature interaction network among amino acids. A recently engineered small protein-like peptide with a simple acid composition features temperature-driven alpha-helix beta-sheet change. Here we studied this molecular dynamics simulations. We...
Longitudinal EEG recorded by implanted devices is critical for understanding and managing epilepsy. Recent research reports patient-specific, multi-day cycles in device-detected epileptiform events that coincide with increased likelihood of clinical seizures. Understanding these could elucidate mechanisms generating seizures advance drug neurostimulation therapies.
Near-threshold perception is a paradigm case of awareness diverging from reality - the an unchanging stimulus can vacillate undetected to clearly perceived. The amplitude low-frequency brain oscillations particularly in alpha-band (8-13 Hz) has emerged as reliable predictor trial-to-trial variability perceptual decisions based on simple, low-level stimuli. Here, we addressed question how spontaneous oscillatory impacts subjective and objective aspects using high-level visual Human observers...
Consciousness never fades during wake. However, if awakened from sleep, sometimes we report dreams and no experiences. Traditionally, dreaming has been identified with REM characterized by a wake-like, globally ‘activated’, high-frequency EEG. also occurs in NREM prominent low-frequency activity. This challenges our understanding of the neural correlates conscious experiences sleep. Using high-density EEG, contrasted presence absence within In both was associated local decrease activity...
Abstract Patients with drug-resistant temporal lobe epilepsy often undergo intracranial EEG recording to capture multiple seizures in order lateralize the seizure onset zone. This process is associated morbidity and ends postoperative recurrence. Abundant interictal (between-seizure) data are captured during this process, but these currently play a small role surgical planning. Our objective was predict laterality of zone using patients epilepsy. We performed retrospective cohort study...
Abstract Intracranial EEG is used for two main purposes: to determine (i) if epileptic networks are amenable focal treatment and (ii) where intervene. Currently, these questions answered qualitatively differently across centres. There a need quantify the focality of systematically, which may guide surgical decision-making, enable large-scale data analysis facilitate multi-centre prospective clinical trials. We analysed interictal from 101 patients with drug-resistant epilepsy who underwent...
Magneto/electroencephalography (M/EEG) studies of dreaming are an essential paradigm in the investigation neurocognitive processes human consciousness during sleep, but they limited by number observations that can be collected per study. Dream research also involves substantial methodological and conceptual variability, which poses problems for integration results. To address these issues, here we present DREAM database—an expanding collection standardized datasets on sleep M/EEG combined...
Abstract Near-threshold perception is a paradigm case of perceptual reports diverging from reality – an unchanging stimulus can vacillate undetected to clearly perceived. Among the many factors that predict whether will reach awareness, amplitude low-frequency brain oscillations - particularly in alpha frequency band (8-13 Hz) has emerged as reliable predictor trial-to-trial variability decisions. Analysis grounded signal detection theory suggest strong prestimulus diminish subjective...
We describe an educational intervention for neurology residents aimed at developing feedback skills. An objective structured clinical examination case was designed to simulate the provision of a medical student. After simulated session, received structured, individualized on their performance and then participated in group discussion about methods. Survey data were collected from standardized student regarding residents' assessments Objective Structured Clinical Examination case. This...
What mechanisms underlie the prioritization of neural representations visually perceived information to guide behavior? We assessed dynamics whereby attention biases competition for representation visual stimuli by enhancing relevant and suppressing irrelevant. Multivariate pattern analysis (MVPA) classifiers were trained discriminate patterns fMRI activity associated with each three stimuli, within several predefined ROIs. Participants performed a change-detection task wherein two presented...
Intracranial EEG (IEEG) is used for 2 main purposes, to determine: (1) if epileptic networks are amenable focal treatment and (2) where intervene. Currently these questions answered qualitatively sometimes differently across centers. There a need objective, standardized methods guide surgical decision making enable large scale data analysis centers prospective clinical trials. We analyzed interictal from 101 patients with drug resistant epilepsy who underwent presurgical evaluation IEEG....
Abstract Mesial temporal lobe epilepsy (mTLE) is a common localization of drug-resistant in adults. Patients often undergo intracranial EEG (iEEG) monitoring to confirm and determine candidacy for focal ablation or resection. Clinicians primarily base surgical decision-making on seizure onset patterns, with imaging abnormalities information from interictal epileptiform discharge (spikes) used as ancillary data. How the morphology timing spikes within multi-electrode sequences may inform...