A5059089114- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Zebrafish Biomedical Research Applications
- Epilepsy research and treatment
- Receptor Mechanisms and Signaling
- Neurosurgical Procedures and Complications
- Surgical Simulation and Training
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Fractures and Fixation Techniques
- Amoebic Infections and Treatments
- Pelvic floor disorders treatments
- Hemoglobinopathies and Related Disorders
- Reproductive tract infections research
- Meningioma and schwannoma management
- Augmented Reality Applications
- Visual perception and processing mechanisms
- Facial Trauma and Fracture Management
- Radiology practices and education
- Traumatic Ocular and Foreign Body Injuries
- Neuroinflammation and Neurodegeneration Mechanisms
- Anatomy and Medical Technology
- Cardiac, Anesthesia and Surgical Outcomes
Dartmouth Hospital
2024
Philadelphia VA Medical Center
2023-2024
University of Pennsylvania
2017-2024
Dartmouth College
2020-2024
New York University Shanghai
2024
Abstract Memories are encoded in neural ensembles during learning 1–6 and stabilized by post-learning reactivation 7–17 . Integrating recent experiences into existing memories ensures that contain the most recently available information, but how brain accomplishes this critical process remains unclear. Here we show mice, a strong aversive experience drives offline ensemble of not only memory also neutral formed 2 days before, linking fear to previous memory. Fear specifically links...
Abstract Memories are encoded in neural ensembles during learning and stabilized by post-learning reactivation. Integrating recent experiences into existing memories ensures that contain the most recently available information, but how brain accomplishes this critical process remains unknown. Here we show mice, a strong aversive experience drives offline ensemble reactivation of not only memory also neutral formed two days prior, linking fear from to previous memory. We find specifically...
Experience replay is a powerful mechanism to learn efficiently from limited experience. Despite several decades of compelling experimental results, the factors that determine which experiences are selected for remain unclear. A particular challenge current theories on tasks feature unbalanced experience, rats paradoxically less-experienced trajectory. To understand why, we simulated feedforward neural network with two regimes: rich learning (structured representations tailored task demands)...
✓Dislocation of the mandibular condyle into middle cranial fossa is a rare event due to anatomical and biome chanical factors. The authors report case 12-year-old girl who presented with this condition after colliding classmate. One day her injury, patient demonstrated an inability close mouth completely, she had minor tenderness palpation anterior tragus, without neurological deficits. Imaging studies frac tured glenoid intrusion mandible cavity. Open reduction was performed, reconstructed...
Abstract Intracranial EEG is used for two main purposes: to determine (i) if epileptic networks are amenable focal treatment and (ii) where intervene. Currently, these questions answered qualitatively differently across centres. There a need quantify the focality of systematically, which may guide surgical decision-making, enable large-scale data analysis facilitate multi-centre prospective clinical trials. We analysed interictal from 101 patients with drug-resistant epilepsy who underwent...
Theta oscillations (3-8 Hz) in the human brain have been linked to perception, cognitive control, and spatial memory, but their relation motor system is less clear. We tested hypothesis that theta coordinate distributed behaviorally relevant neural representations during movement using intracranial electroencephalography (iEEG) recordings from nine patients (n = 490 electrodes) as they performed a simple instructed task. Using high frequency activity (HFA; 70-200 marker of local spiking...
<h3>ABSTRACT</h3> <h3>Background:</h3> We present a "Do-It-Yourself" method to build an affordable augmented reality heads-up display system (AR-HUD) capable of displaying intraoperative images. All components are commercially available products, which the surgeons may use in their own practice for educational and research purposes. <h3>Methods:</h3> Moverio BT 35-E smart glasses were connected operating room imaging modalities (ie, fluoroscopy 3D navigation platforms) via high-definition...
We report a case of spinal epidural abscess (SEA) in 58-year-old woman who had recently been diagnosed with gonococcal infection, but did not receive guideline-recommended therapy. She presented back pain and signs symptoms pelvic inflammatory disease (PID). MRI the spine demonstrated extending from L4-L5 to T10. underwent T10-L1 L3-L4 laminectomies for evacuation Gardnerella vaginalis Prevotella amnii were isolated fluid cultures. Our demonstrates SEA as rare, morbid complication PID...
Summary The rodent hippocampus constructs statistically independent representations across environments (“global remapping”) and assigns individual neuron firing fields to locations within an environment in apparently random fashion, processes thought contribute the role of episodic memory. This mapping implies that it should be challenging predict hippocampal encoding a given experience one subject based on same another subject. Contrary this prediction, we find by constructing common...
The neural mechanisms of motor planning have been extensively studied in rodents. Preparatory activity the frontal cortex predicts upcoming choice, but limitations typical tasks made it challenging to determine whether spatial information is a self-centered direction reference frame or world-centered position frame. Here, we trained male rats make delayed visually guided orienting movements six different directions, with four target positions for each direction, which allowed us disentangle...
OBJECTIVE Although it is known that intersurgeon variability in offering elective surgery can have major consequences for patient morbidity and healthcare spending, data addressing within neurosurgery are scarce. The authors performed a prospective peer review study of randomly selected cases order to assess the extent consensus regarding decision offer among attending neurosurgeons across one large academic institution. METHODS All consecutive patients who had undergone standard inpatient...
Abstract The neural mechanisms of motor planning have been extensively studied in rodents. Preparatory activity the frontal cortex predicts upcoming choice, but limitations typical tasks made it challenging to determine whether spatial information is a self-centered direction reference frame or world-centered position frame. Here, we trained rats make delayed visually-guided orienting movements six different directions, with four target positions for each direction, which allowed us...