A5091766898- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Neural dynamics and brain function
- Prenatal Substance Exposure Effects
- Neuroscience and Neural Engineering
- Vitamin D Research Studies
- Neurological disorders and treatments
- HIV-related health complications and treatments
University of Pennsylvania
2023-2024
California University of Pennsylvania
2024
University of Miami
2018
Longitudinal EEG recorded by implanted devices is critical for understanding and managing epilepsy. Recent research reports patient-specific, multi-day cycles in device-detected epileptiform events that coincide with increased likelihood of clinical seizures. Understanding these could elucidate mechanisms generating seizures advance drug neurostimulation therapies.
Studies of intracranial EEG networks have been used to reveal seizure generators in patients with drug-resistant epilepsy. Intracranial is implanted capture the epileptic network, collection brain tissue that forms a substrate for seizures start and spread. Interictal measures activity at baseline, computed during this state can aberrant without requiring recordings. network analyses require choosing reference applying statistical functional connectivity. Approaches these technical choices...
Abstract Patients with drug-resistant temporal lobe epilepsy often undergo intracranial EEG recording to capture multiple seizures in order lateralize the seizure onset zone. This process is associated morbidity and ends postoperative recurrence. Abundant interictal (between-seizure) data are captured during this process, but these currently play a small role surgical planning. Our objective was predict laterality of zone using patients epilepsy. We performed retrospective cohort study...
Abstract Mesial temporal lobe epilepsy (mTLE) is a common localization of drug-resistant in adults. Patients often undergo intracranial EEG (iEEG) monitoring to confirm and determine candidacy for focal ablation or resection. Clinicians primarily base surgical decision-making on seizure onset patterns, with imaging abnormalities information from interictal epileptiform discharge (spikes) used as ancillary data. How the morphology timing spikes within multi-electrode sequences may inform...
Longitudinal EEG recorded by implanted devices is critical for understanding and managing epilepsy. Recent research reports patient-specific, multi-day cycles in device-detected epileptiform events that coincide with increased likelihood of clinical seizures. Understanding these could elucidate mechanisms generating seizures advance drug neurostimulation therapies.We hypothesize seizure-correlated are present background neural activity, independent interictal spikes, may disrupt cycles.We...